Correlations of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and acute physiology, and chronic health evaluation II score with prognosis of elderly patients with chronic obstructive pulmonary disease and respiratory failure.

Abstract

Objective: To investigate the correlations of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and acute physiology and chronic health evaluation II (APACHE II) score with the prognosis of elderly patients with chronic obstructive pulmonary disease (COPD) and respiratory failure.

Methods: A retrospective analysis was conducted on 110 elderly COPD patients with respiratory failure. General information, inflammatory indices (PLR, NLR), and pulmonary function scores were collected. Statistical comparisons were made using t-tests and chi-square tests. ROC curve analysis evaluated the predictive value of the investigated variables.

Results: Compared to the good-prognosis group, the poor-prognosis group exhibited significantly higher PLR, NLR levels, as well as higher COPD Assessment Test (CAT) and APACHE II scores. Logistic regression analysis identified PLR, NLR, and APACHE II scores as independent prognostic risk factors for COPD patients with respiratory failure. ROC curve analysis confirmed the high predictive value of these variables in forecasting prognosis.

Conclusion: PLR, NLR, and APACHE II scores, exhibiting correlations with prognosis in elderly COPD patients with respiratory failure, can serve as valuable biomarkers for patient prognosis.