Enhancment of zebrafish (Danio rerio) immune and antioxidant systems using medicinal plant extracts encapsulated in alginate-chitosan nanocapsules with slow sustained release.

IF 1.8 4区 生物学 Q3 BIOLOGY Biologia futura Pub Date : 2024-09-15 DOI:10.1007/s42977-024-00244-0
Abdolmajid Valipour, Behrooz Heidari, Hadi Esmaeili Gouvarchin Ghaleh, Maryam Ghorbani, Alireza Shahriari, Maryam Iman, Ebrahim Salimi-Sabour
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Abstract

This study aimed to screen 10 medicinal plant extracts on zebrafish (Danio rerio), evaluating their impact on the complement system, immunoglobulin M (IgM) levels, lysozyme, and peroxidase activity, while also enhancing their efficacy through the gradual release using alginate-chitosan nanocapsules. The prepared methanolic extracts were combined with fish feed. The fish were divided into 12 groups, including 10 treatment groups, a positive and a negative control group. Results showed varying impacts of the extracts on the immune and antioxidant systems, with Cinnamon (Cinnamon cassia) and Hypericum (Hypericum perforatum) extracts demonstrating the most significant effects. Subsequently, Cinnamon and Hypericum extract were encapsulated in alginate-chitosan nanocapsules to assess their impact on zebrafish immune parameters, separately and synergistically. Gradual release of the extracts from the nanocapsules was observed, with slower release at pH 2 compared to pH 7. Overall, Cinnamon and Hypericum extracts exhibited substantial immune system enhancement, and their encapsulation in nanocapsules improved their effects on zebrafish immune parameters. These findings suggest using these encapsulated extracts to enhance immune responses in aquatic organisms.

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使用包裹在海藻酸盐-壳聚糖纳米胶囊中的药用植物提取物缓慢持续释放,增强斑马鱼(Danio rerio)的免疫和抗氧化系统。
本研究旨在筛选斑马鱼(Danio rerio)身上的 10 种药用植物提取物,评估它们对补体系统、免疫球蛋白 M(IgM)水平、溶菌酶和过氧化物酶活性的影响,同时通过使用海藻酸-壳聚糖纳米胶囊的渐进释放提高其药效。制备的甲醇提取物与鱼饲料混合。将鱼分成 12 组,包括 10 个处理组、一个阳性对照组和一个阴性对照组。结果显示,提取物对免疫和抗氧化系统的影响各不相同,其中肉桂和金丝桃提取物的影响最为显著。随后,将肉桂和金丝桃提取物封装在藻酸盐-壳聚糖纳米胶囊中,以评估它们分别和协同对斑马鱼免疫参数的影响。观察到提取物从纳米胶囊中逐渐释放出来,在 pH 值为 2 时释放速度比 pH 值为 7 时慢。总体而言,肉桂和金丝桃提取物表现出显著的免疫系统增强作用,将它们封装在纳米胶囊中可改善它们对斑马鱼免疫参数的影响。这些发现建议使用这些封装提取物来增强水生生物的免疫反应。
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Biologia futura
Biologia futura Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
3.50
自引率
0.00%
发文量
27
期刊介绍: How can the scientific knowledge we possess now influence that future? That is, the FUTURE of Earth and life − of humankind. Can we make choices in the present to change our future? How can 21st century biological research ask proper scientific questions and find solid answers? Addressing these questions is the main goal of Biologia Futura (formerly Acta Biologica Hungarica). In keeping with the name, the new mission is to focus on areas of biology where major advances are to be expected, areas of biology with strong inter-disciplinary connection and to provide new avenues for future research in biology. Biologia Futura aims to publish articles from all fields of biology.
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