Advances in biosynthesis and downstream processing of diols

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-09-19 DOI:10.1016/j.biotechadv.2024.108455

Yongfei Liu , Chijian Zhang , An-Ping Zeng

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Abstract

Diols are important platform chemicals with a wide range of applications in the fields of chemical and pharmaceutical industries, food, feed and cosmetics. In particular, 1,3-propanediol (PDO), 1,4-butanediol (1,4-BDO) and 1,3-butanediol (1,3-BDO) are appealing monomers for producing industrially important polymers and plastics. Therefore, the commercialization of bio-based diols is highly important for supporting the growth of biomanufacturing for the fiber industry. This review focuses primarily on the microbial production of PDO, 1,4-BDO and 1,3-BDO with respect to different microbial strains and biological routes. In addition, metabolic platforms which are designed to produce various diols using generic bioconversion strategies are reviewed for the first time. Finally, we also summarize and discuss recent developments in the downstream processing of PDO according to their advantages and drawbacks, which is taken as an example to present the prospects and challenges for industrial separation and purification of diols from microbial fermentation broth.

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二元醇的生物合成和下游加工取得进展。

二元醇是重要的平台化学品，在化工、制药、食品、饲料和化妆品领域有着广泛的应用。其中，1,3-丙二醇（PDO）、1,4-丁二醇（1,4-BDO）和 1,3-丁二醇（1,3-BDO）是生产工业用聚合物和塑料的重要单体。因此，生物基二醇的商业化对于支持纤维行业生物制造的发展非常重要。本综述主要针对不同微生物菌株和生物途径，重点介绍微生物生产 PDO、1,4-BDO 和 1,3-BDO。此外，还首次综述了利用一般生物转化策略生产各种二元醇的代谢平台。最后，我们还根据其优缺点总结并讨论了 PDO 下游加工的最新进展，并以此为例介绍了从微生物发酵液中分离和纯化二元醇的工业前景和挑战。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.