Folic Acid as a Potential Vitamin in Glycemic Control: A Systematic Review.

IF 4.6 3区医学 Q1 NUTRITION & DIETETICS Current Nutrition Reports Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI:10.1007/s13668-024-00565-5

Gökçe Sueda Aydoğdu, Buket Akyakar, Zeynep Kalaycı, Ayda Uçar, Makbule Gezmen-Karadağ

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Abstract

Purpose: This systematic review aims to examine the relationship between serum folate level and folic acid supplements with glycemic control parameters (fasting blood glucose (FBG), insulin level, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and Hemoglobin A1C (HbA1c)) in adult individuals with current studies.

Methods: In this study, which was designed as a systematic review, the searches were performed on Web of Science, Science Direct, Medline, Wiley, and Cochrane Library databases between April 10, 2023, and May 10, 2023, and the searches were updated between October 16, 2023, and November 14, 2023. Of the 1855 studies obtained from the screening, 17 met the criteria and were included in the systematic review. The PROSPERO system registered the study protocol (ID: CRD42023472434).

Recent findings: Although no significant correlation was found between serum folate levels and glycemic control parameters in most of the cross-sectional studies included in this systematic review, most of the randomized controlled trials showed that glycemic control parameters (FBG, insulin, HOMA-IR) decreased significantly in the intervention group receiving folic acid supplementation compared to the control group. However, study durations were short, and HbA1c needed to be evaluated in most studies. This makes it difficult to get information about the long-term effects of folic acid supplementation. More comprehensive studies should be conducted to draw more precise conclusions about the relationship between folic acid levels and folic acid supplementation with glycemic control parameters.

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叶酸是控制血糖的潜在维生素：系统综述

目的：本系统综述旨在通过目前的研究，探讨成人血清叶酸水平和叶酸补充剂与血糖控制参数（空腹血糖（FBG）、胰岛素水平、胰岛素抵抗静态模型评估（HOMA-IR）和血红蛋白A1C（HbA1c））之间的关系：本研究为系统性综述，于 2023 年 4 月 10 日至 2023 年 5 月 10 日期间在 Web of Science、Science Direct、Medline、Wiley 和 Cochrane Library 数据库中进行了检索，并于 2023 年 10 月 16 日至 2023 年 11 月 14 日期间对检索结果进行了更新。在筛选出的 1855 项研究中，有 17 项符合标准，被纳入系统综述。PROSPERO系统注册了该研究方案（ID：CRD42023472434）：尽管在本系统综述所纳入的大多数横断面研究中未发现血清叶酸水平与血糖控制参数之间存在明显的相关性，但大多数随机对照试验显示，与对照组相比，叶酸补充剂干预组的血糖控制参数（FBG、胰岛素、HOMA-IR）明显下降。然而，研究持续时间较短，而且大多数研究都需要对 HbA1c 进行评估。因此很难获得叶酸补充剂的长期效果信息。应进行更全面的研究，以便就叶酸水平和叶酸补充与血糖控制参数之间的关系得出更准确的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.