Latent Iron Deficiency in Neonates With and Without Risk Factors for Poor In-Utero Iron Status.

IF 1.7 4区医学 Q2 PEDIATRICS Indian pediatrics Pub Date : 2024-11-15 Epub Date: 2024-09-10

Puneeth Amaresh Babu, Ajoy Kumar Garg, Saroj Kumar Patnaik

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引用次数: 0

Abstract

Objective: To determine the proportion of latent iron deficiency (LID) in neonates delivered at more than 34 weeks gestation with and without risk factors for in-utero iron deficiency.

Method: This observational study enrolled neonates delivered at more than 34 weeks gestation. Maternal antenatal history, risk factors for placental insufficiency, hemoglobin, and serum ferritin levels were collected upon admission for confinement. Neonates were categorized based on the presence of risk factors, and further categorized based on ferritin concentrations (cord blood or venous blood < 72 hours) into those with ferritin > 75 ng/mL (normal iron status) and those with ferritin between 11-75 ng/mL (LID).

Results: Among 559 neonates, 295 had underlying risk factors for poor in-utero iron status. Overall, 45 (9.8%) neonates had LID with an incidence of 10.5% in those with risk factors and 5.3% in those without risk factors [Odds Ratio (95% CI) 2.09 (1.08, 4.03); P value = 0.02]. Maternal anemia and gestational hypertension were found to be significant independent risk factors for LID.

Conclusion: This study highlights the higher LID in at-risk neonates, emphasizing the need for targeted interventions to prevent iron deficiency.

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有无胎儿铁状况不良风险因素的新生儿潜伏铁缺乏症

目的确定妊娠 34 周以上分娩的新生儿中存在和不存在胎儿铁缺乏症风险因素的潜在铁缺乏症（LID）比例：这项观察性研究招募了妊娠 34 周以上分娩的新生儿。在入院分娩时收集产妇的产前病史、胎盘功能不全的危险因素、血红蛋白和血清铁蛋白水平。根据是否存在风险因素对新生儿进行分类，并根据铁蛋白浓度（脐带血或静脉血<72小时）进一步将新生儿分为铁蛋白>75纳克/毫升（铁状态正常）和铁蛋白介于11-75纳克/毫升（低铁血症）两类：结果：在 559 名新生儿中，有 295 名存在胎儿期铁状况不佳的潜在风险因素。总体而言，有 45 名新生儿（9.8%）患有 LID，其中有风险因素的新生儿发病率为 10.5%，无风险因素的新生儿发病率为 5.3%[Odds Ratio (95% CI) 2.09 (1.08, 4.03)；P 值 = 0.02]：本研究强调了高危新生儿的 LID 较高，因此需要采取有针对性的干预措施来预防贫血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.