bSSFP Phase Contrast (PC-SSFP) at 0.55T Applied to Aortic Flow.

IF 4.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-09-13 DOI:10.1016/j.jocmr.2024.101098
Jie Xiang, Rajiv Ramasawmy, Felicia Seemann, Dana C Peters, Adrienne E Campbell-Washburn
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引用次数: 0

Abstract

Background: There is a growing interest in the development and application of mid-field (0.55T) for cardiac MR, including flow imaging. However, aortic flow imaging at 0.55T has limited SNR, especially in diastolic phases where there is reduced inflow-driven contrast for spoiled gradient echo (GRE) sequences. The low SNR can limit the accuracy of flow and regurgitant fraction measurements.

Methods: In this work, we developed a 2D phase contrast (PC) acquisition with balanced steady state free precession (bSSFP), termed PC-SSFP, for flow imaging and quantification at 0.55T. This PC-SSFP approach precisely nulls the 0th and 1st gradient moments at both the TE and TR, except for the flow-encoded acquisition, for which the 1st gradient moment at the TE is determined by the VENC. Our proposed sequence was tested in both phantoms and in healthy volunteers (n=11), to measure aortic flow. In volunteers, both a breath-hold and a free-breathing protocol, with averaging to increase SNR, were obtained. Total flow, peak flow, cardiac output and SNR were compared for PC-SSFP and PC-GRE. Stroke volumes were also measured and compared to planimetry method.

Results: In a phantom, SNR was significantly higher using PC-SSFP compared to PC-GRE (25.5±9.6 vs 8.2±2.9), and the velocity measurements agreed well (R = 1.00). In healthy subjects, for both breath-hold (bh) and free-breathing (fb) protocols, PC-SSFP measured accurate peak flow (fb: R = 0.99, bh: R = 0.96) and cardiac output (fb: R = 0.98, bh: R = 0.88), compared to PC-GRE, accurate stroke volume (fb: R = 0.94, bh: R = 0.97), compared to planimetry measurement, and offered constant high SNR (fb: 28±9 vs 18±6, bh: 24±7 vs 11±3) over the cardiac cycle in 11 subjects.

Conclusion: PC-SSFP is a more reliable evaluation tool for aortic flow quantification, when compared to the conventional PC-GRE method at 0.55T, providing higher SNR, and thus potentially more accurate flows.

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将 0.55T 下的 bSSFP 相位对比(PC-SSFP)应用于主动脉血流。
背景:人们对中场(0.55T)心脏磁共振成像(包括血流成像)的开发和应用越来越感兴趣。然而,0.55T 下的主动脉血流成像信噪比有限,尤其是在舒张期,因为在舒张期,破坏梯度回波(GRE)序列的流入驱动对比度降低。低信噪比会限制血流和反流分数测量的准确性:在这项工作中,我们开发了一种二维相位对比(PC)采集与平衡稳态自由前冲(bSSFP),称为 PC-SSFP,用于在 0.55T 下进行血流成像和量化。这种PC-SSFP方法可精确地使TE和TR上的第0和第1梯度矩为零,但血流编码采集除外,其TE上的第1梯度矩由VENC决定。我们提出的序列在模型和健康志愿者(n=11)中进行了测试,以测量主动脉血流。在志愿者中,我们采用了屏气和自由呼吸两种方案,并进行了平均以提高信噪比。对 PC-SSFP 和 PC-GRE 的总流量、峰值流量、心输出量和信噪比进行了比较。还测量了卒中量,并与平面测量法进行了比较:结果:在模型中,PC-SSFP 的信噪比明显高于 PC-GRE(25.5±9.6 vs 8.2±2.9),速度测量结果一致(R = 1.00)。在健康受试者中,无论是屏气(bh)还是自由呼吸(fb)方案,PC-SSFP 都能准确测量峰值流量(fb:R = 0.99,bh:R = 0.96)和心输出量(fb:R = 0.98,bh:R = 0.与 PC-GRE 相比,PC-SSFP 更准确(fb: R = 0.94,bh: R = 0.97);与平扫测量相比,PC-SSFP 更准确(fb: R = 0.99,bh: R = 0.96);与 PC-GRE 相比,PC-SSFP 在 11 名受试者的整个心动周期中提供恒定的高信噪比(fb: 28±9 vs 18±6, bh: 24±7 vs 11±3):PC-SSFP在0.55T下与传统的PC-GRE方法相比,是一种更可靠的主动脉血流量化评估工具,能提供更高的信噪比,从而可能获得更准确的血流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.90
自引率
12.50%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.
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