Snake venom bioprospecting as an approach to finding potential anti-glioblastoma molecules.

IF 1.8 3区 医学 Q4 TOXICOLOGY Journal of Venomous Animals and Toxins Including Tropical Diseases Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI:10.1590/1678-9199-JVATITD-2024-0015
Javier Orozco-Mera, Alejandro Montoya-Gómez, Daiana Silva Lopes, Eliécer Jiménez-Charris
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Abstract

Glioblastoma (GB) is the most common type of malignant tumor of the central nervous system, responsible for significant morbidity and with a 5-year overall relative survival of only 6.8%. Without advances in treatment in the last twenty years, the standard of care continues to be maximum safe resection, Temozolomide (TMZ), and radiotherapy. Many new trials are ongoing, and despite showing increased progression-free survival, these trials did not improve overall survival. They did not consider the adverse effects of these therapies. Therefore, an increasing number of bioprospecting studies have used snake venom molecules to search for new strategies to attack GB selectively without producing side effects. The present review aims to describe GB characteristics and current and new approaches for treatment considering their side effects. Besides, we focused on the antitumoral activity of snake venom proteins from the Viperidae family against GB, exploring the potential for drug design based on in vitro and in vivo studies. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. In January 2024, a systematic search was performed in the PubMed, EMBASE, and Web of Science databases from January 2000 to December 2023. Search terms were selected based on the population/exposure/outcome (PEO) framework and combined using Boolean operators ("AND", "OR"). The search strategy used these terms: glioblastoma, glioma, high-grade glioma, WHO IV glioma, brain cancer, snake venom, Viperidae, and bioprospection. We identified 10 in vivo and in vitro studies with whole and isolated proteins from Viperidae venom that could have antitumor activity against glioblastoma. Studies in bioprospecting exploring the advantage of snake venom proteins against GB deserve to be investigated due to their high specificity, small size, inherent bioactivity, and few side effects to cross the blood-brain barrier (BBB) to reach the tumor microenvironment.

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将蛇毒生物勘探作为寻找潜在抗胶质母细胞瘤分子的一种方法。
胶质母细胞瘤(GB)是中枢神经系统最常见的恶性肿瘤,发病率高,5 年总体相对生存率仅为 6.8%。过去二十年来,由于治疗方法没有取得进展,目前的治疗标准仍然是最大限度安全切除、替莫唑胺(TMZ)和放射治疗。许多新的试验正在进行中,尽管无进展生存期有所延长,但这些试验并未改善总生存期。这些试验并未考虑这些疗法的不良反应。因此,越来越多的生物勘探研究利用蛇毒分子寻找新的策略,在不产生副作用的情况下选择性地攻击 GB。本综述旨在描述 GB 的特征以及考虑到其副作用的当前和新的治疗方法。此外,我们还重点研究了蝰科蛇毒蛋白对 GB 的抗肿瘤活性,根据体外和体内研究探索药物设计的潜力。本综述遵循了系统综述和元分析首选报告项目(PRISMA)指南。2024 年 1 月,对 2000 年 1 月至 2023 年 12 月期间的 PubMed、EMBASE 和 Web of Science 数据库进行了系统检索。检索词的选择基于人群/暴露/结果(PEO)框架,并使用布尔运算符("AND"、"OR")进行组合。搜索策略使用了以下术语:胶质母细胞瘤、胶质瘤、高级别胶质瘤、WHO IV 级胶质瘤、脑癌、蛇毒、蝰科和生物检测。我们确定了 10 项体内和体外研究,这些研究使用了从蝰科毒液中提取的可能对胶质母细胞瘤具有抗肿瘤活性的完整和分离蛋白质。由于蛇毒蛋白具有特异性强、体积小、固有的生物活性以及穿过血脑屏障(BBB)到达肿瘤微环境的副作用小等优点,因此探索蛇毒蛋白抗胶质母细胞瘤优势的生物勘探研究值得研究。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
期刊最新文献
Isolation and cDNA cloning of four peptide toxins from the sea anemone Heteractis aurora. Human visceral leishmaniasis and polymorphisms in interleukin-coding genes: a systematic review. Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review. Snake venom bioprospecting as an approach to finding potential anti-glioblastoma molecules. Immunomodulatory effect of Tityus sp. in mononuclear cells extracted from the blood of rheumatoid arthritis patients.
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