Exploring blood pressure dynamics and oxidative stress markers in an animal model of polycystic ovary syndrome.

IF 0.9 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI:10.5455/OVJ.2024.v14.i8.14
Yudit Oktanella, Hana Ismiawati, Hafizh Zakaria, Handayu Untari
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Abstract

Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by elevated androgen levels, heightened insulin secretion, and dysregulation of luteinizing hormone and follicle-stimulating hormone. This disorder results in metabolic disruptions, while the irregular estrous cycles associated with PCOS impact cellular functions like growth, movement, and alterations in cell adhesion within the tissue matrix.

Aim: This study aims to identify the blood tension, serum malondialdehyde (MDA) levels, and serum Metalloproteinase-1 (MMP-1) in rat models of PCOS. The study was conducted using female Wistar rats aged 6 months weighing between 130 and 180 g.

Methods: The rats were divided into three treatment groups: negative control, induction of testosterone propionate (TP) at a dose of 100 mg/kg BW IP for 12 days, and induction of estradiol valerate (EV) at a dose of 2 mg/kg BW IP for 2 days. Data were analyzed quantitatively using a one-way analysis of variance followed by a Posthoc Test using the least significant difference with a confidence level of 95%.

Results: The research results indicate that the average blood pressure of TP Group and EV Group did not differ significantly from the negative control (p > 0.05). Serum MDA levels were significantly different in the TP Group compared to the negative control (p < 0.05). On the other hand, MMP-1 levels showed no significant difference (p > 0.05) among all the treatment groups.

Conclusion: The findings of this study suggest that TP induction in a rat model of PCOS can potentially contribute to oxidative stress and lipid peroxidation, but does not significantly affect blood pressure or serum MMP-1 levels.

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探索多囊卵巢综合征动物模型中的血压动态和氧化应激标记。
背景:多囊卵巢综合征(PCOS)是一种内分泌失调症,其特点是雄激素水平升高、胰岛素分泌增加、黄体生成素和卵泡刺激素失调。目的:本研究旨在确定多囊卵巢综合征大鼠模型的血液张力、血清丙二醛(MDA)水平和血清金属蛋白酶-1(MMP-1)。研究使用雌性 Wistar 大鼠进行,大鼠年龄为 6 个月,体重为 130 至 180 克:大鼠分为三个治疗组:阴性对照组、诱导丙酸睾酮(TP)组(剂量为 100 毫克/千克体重,IP 12 天)和诱导戊酸雌二醇(EV)组(剂量为 2 毫克/千克体重,IP 2 天)。采用单因素方差分析对数据进行定量分析,然后进行置信度为 95% 的差异最小显著性事后检验:研究结果表明,TP 组和 EV 组的平均血压与阴性对照组相比没有显著差异(P > 0.05)。TP 组血清 MDA 水平与阴性对照组相比有明显差异(P < 0.05)。另一方面,所有治疗组的 MMP-1 水平均无明显差异(p > 0.05):本研究结果表明,在多囊卵巢综合症大鼠模型中诱导 TP 有可能导致氧化应激和脂质过氧化,但不会对血压或血清 MMP-1 水平产生明显影响。
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来源期刊
Open Veterinary Journal
Open Veterinary Journal VETERINARY SCIENCES-
CiteScore
1.40
自引率
0.00%
发文量
112
审稿时长
12 weeks
期刊介绍: Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
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