The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats.

IF 0.9 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI:10.5455/OVJ.2024.v14.i8.7

Rochmah Kurnijasanti, Giftania Wardani, Muhammad Rais Mustafa, Sri Agus Sudjarwo

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Abstract

Background: Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders.

Aim: The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wistar rats.

Methods: For the current study, forty rats were divided into five groups of rats that were used in good condition. In-vivo experiments of fucoidan were carried out in Wistar albino rats, such as the cyclophosphamide-caused myelosuppression, the delayed-type hypersensitivity (DTH) response, the phagocytic activity, the haemagglutinating antibody (HA) titer, and the neutrophil adhesion test.

Results: The phagocytic index increased significantly in response to Fucoidan in a dose-dependent manner, as well as enhanced DTH reaction, and HA titer caused by sheep red blood cells sheep red blood cells. Additionally, fucoidan decreased myelosuppression in rats after cyclophosphamide treatment and enhanced neutrophil adhesion with nylon fiber.

Conclusion: These findings imply that fucoidan has immunostimulant properties and could potentially utilised to treat immune-depression diseases.

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褐藻糖胶对 Wistar 大鼠细胞和体液免疫反应的免疫刺激作用。

背景：目的：本研究旨在探讨褐藻糖胶在白化 Wistar 大鼠体内的免疫刺激特性：在本次研究中，40 只大鼠被分为 5 组，每组大鼠的状况良好。在 Wistar 白化大鼠体内进行了褐藻糖胶的体内实验，如环磷酰胺引起的骨髓抑制、迟发型超敏反应（DTH）、吞噬细胞活性、血凝抗体（HA）滴度和中性粒细胞粘附试验：结果：褐藻糖胶能明显提高吞噬细胞指数，且呈剂量依赖性，还能增强绵羊红细胞引起的DTH反应和HA滴度。此外，褐藻糖胶还能减轻环磷酰胺治疗后大鼠的骨髓抑制，增强中性粒细胞与尼龙纤维的粘附性：这些研究结果表明，褐藻糖胶具有免疫刺激特性，可用于治疗免疫抑制疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.