Comparative study of lung cancer between smokers and nonsmokers: A real-world study based on the whole population from Tianjin City, China.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Tobacco Induced Diseases Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.18332/tid/192191

Wenlong Zheng, Guohong Jiang, Chong Wang, Luning Xun, Chengfeng Shen, Shuang Zhang, Hui Zhang, Qingxin Zhou, Meiqiu Xie, Xiaodan Xue, Dezheng Wang, Jun Lv

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Abstract

Introduction: The purpose of this study was to examine the prevalence, clinical characteristics, and changing trends of non-smokers with lung cancer (LC) based on data from a population-wide cancer registry in northern China.

Methods: The study used LC incidence and follow-up data from 2010 to 2019 from the Cancer Registry System of Tianjin city, which included 82769 cases. Trends in the incidence and proportion of non-smokers with LC were examined by joinpoint regression analysis. Life table and Cox survival analyses were used to calculate the survival rates and compare the death hazard ratios (HRs) in different groups, respectively.

Results: Among the 82769 new diagnosis cases of LC during 2010 to 2019, there were 34589 (41.8%) current smokers, 14913 (18.0%) ex-smokers, 28123 (34.0%) non-smokers, and 5144 (6.2%) unknowns. The proportion of non-smokers changed slightly from 2010 (35.36%) to 2019 (36.87%) (annual percentage change, APC= -0.01%, p>0.05). This proportion declined in men (2010 vs 2019; 22.06% vs 20.66%) and increased in women (2010 vs 2019; 53.02% vs 62.35%), and in the 0-44 years age group it showed an upward trend from 2015 to 2019 (APC=4.82%, 95% CI: 1.8-7.9). Compared with smokers with LC, non-smokers with LC were predominantly females (64.15% vs 27.26%), had a predominantly adenocarcinoma histological subtypes (76.71% vs 42.22%), and had a 20% lower risk of death than smokers (HR=0.80; 95% CI: 0.78-0.81).

Conclusions: The proportion of non-smokers with LC was relatively high in northern China, with an increasing trend in the proportion of females and younger age groups. Non-smokers with LC had different epidemiological and clinical characteristics compared with smokers with LC.

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吸烟者与非吸烟者肺癌比较研究：基于中国天津市全体人口的真实世界研究。

简介：本研究的目的是根据中国北方人口癌症登记数据，研究非吸烟者肺癌（LC）的患病率、临床特征和变化趋势：本研究的目的是基于中国北方全人群癌症登记数据，研究非吸烟者肺癌（LC）的患病率、临床特征和变化趋势：研究使用了天津市肿瘤登记系统 2010 年至 2019 年的肺癌发病率和随访数据，共纳入 82769 例病例。通过连接点回归分析研究了非吸烟者中 LC 发病率和比例的变化趋势。采用生命表和Cox生存分析法分别计算不同组别的生存率和比较死亡危险比（HRs）：在2010年至2019年期间新诊断的82769例LC病例中，有34589人（41.8%）为现吸烟者，14913人（18.0%）为戒烟者，28123人（34.0%）为非吸烟者，5144人（6.2%）为未知者。非吸烟者的比例从 2010 年（35.36%）到 2019 年（36.87%）略有变化（年度百分比变化，APC=-0.01%，P>0.05）。该比例在男性中有所下降（2010 vs 2019; 22.06% vs 20.66%），在女性中有所上升（2010 vs 2019; 53.02% vs 62.35%），在 0-44 岁年龄组中，该比例从 2015 年到 2019 年呈上升趋势（APC=4.82%，95% CI：1.8-7.9）。与患有肺癌的吸烟者相比，患有肺癌的非吸烟者以女性为主（64.15% vs 27.26%），组织学亚型以腺癌为主（76.71% vs 42.22%），死亡风险比吸烟者低20%（HR=0.80；95% CI：0.78-0.81）：在中国北方，非吸烟者中患 LC 的比例相对较高，女性和年轻群体的比例呈上升趋势。与吸烟者相比，非吸烟者 LC 患者具有不同的流行病学和临床特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.