The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review.

MicroRNA (Shariqah, United Arab Emirates) Pub Date : 2024-09-12 DOI:10.2174/0122115366304114240904051429

Amir Mohammad Salehi, Fatemeh Torogi, Farid Azizi Jalilian, Razieh Amini

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Abstract

Introduction: Curcumin is known as a bioactive component that is found in the rhizomes of Curcuma longa. Curcumin is well known for its chemo-preventive and anticancer properties. However, its anticancer mechanism in colorectal cancer treatment is unclear, and some studies have shown that many microRNAs (miRs) could be potential targets for curcumin in colorectal cancer (CRC) treatment, so there is a need for their integration and clarification.

Methods: We systematically searched international databases, including PubMed, Scopus, and Web of Science, until July 2021 by using some relevant keywords.

Results: The search resulted in 87 papers, among which there were 18 related articles. Curcumin was found to cause the upregulation of miR-497, miR-200c, miR-200b, miR-409-3p, miR-34, miR-126, miR-145, miR-206, miR-491, miR-141, miR-429, miR-101, and miR-15a and the downregulation of miR-21, miR-155, miR-221, miR-222, miR-17-5p, miR-130a, miR-27, and miR-20a.

Conclusion: The present review study suggests that curcumin may be useful as a novel therapeutic agent for CRC by altering the expression level of miRs.

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姜黄素作为微 RNA 调节剂在结直肠癌中的潜在作用：系统综述

简介姜黄素是莪术根茎中的一种生物活性成分。姜黄素以其化学预防和抗癌特性而闻名。然而，姜黄素在结直肠癌治疗中的抗癌机制尚不清楚，一些研究表明，许多微RNA（miRs）可能是姜黄素在结直肠癌（CRC）治疗中的潜在靶点，因此有必要对其进行整合和澄清：我们使用一些相关关键词系统地检索了截至 2021 年 7 月的国际数据库，包括 PubMed、Scopus 和 Web of Science：结果：共检索到 87 篇论文，其中相关文章 18 篇。研究发现，姜黄素能上调 miR-497、miR-200c、miR-200b、miR-409-3p、miR-34、miR-126、miR-145、miR-206、miR-491、miR-141、miR-429、miR-101 和 miR-15a，下调 miR-21、miR-155、miR-221、miR-222、miR-17-5p、miR-130a、miR-27 和 miR-20a：本综述研究表明，姜黄素可以通过改变 miRs 的表达水平作为治疗 CRC 的新型药物。

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MicroRNA (Shariqah, United Arab Emirates) Medicine-Medicine (all)

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