{"title":"Single-point macromolecular proton fraction mapping using a 0.3 T permanent magnet MRI system: phantom and healthy volunteer study.","authors":"Yasuhiro Fujiwara, Shoma Eitoku, Nobutaka Sakae, Takahisa Izumi, Hiroyuki Kumazoe, Mika Kitajima","doi":"10.1007/s12194-024-00843-5","DOIUrl":null,"url":null,"abstract":"<p><p>In a 0.3 T permanent-magnet magnetic resonance imaging (MRI) system, quantifying myelin content is challenging owing to long imaging times and low signal-to-noise ratio. macromolecular proton fraction (MPF) offers a quantitative assessment of myelin in the nervous system. We aimed to demonstrate the practical feasibility of MPF mapping in the brain using a 0.3 T MRI. Both 0.3 T and 3.0 T MRI systems were used. The MPF-mapping protocol used a standard 3D fast spoiled gradient-echo sequence based on the single-point reference method. Proton density, T<sub>1</sub>, and magnetization transfer-weighted images were obtained from a protein phantom at 0.3 T and 3.0 T to calculate MPF maps. MPF was measured in all phantom sections to assess its relationship to protein concentration. We acquired MPF maps for 16 and 8 healthy individuals at 0.3 T and 3.0 T, respectively, measuring MPF in nine brain tissues. Differences in MPF between 0.3 T and 3.0 T, and between 0.3 T and previously reported MPF at 0.5 T, were investigated. Pearson's correlation coefficient between protein concentration and MPF at 0.3 T and 3.0 T was 0.92 and 0.90, respectively. The 0.3 T MPF of brain tissue strongly correlated with 3.0 T MPF and literature values measured at 0.5 T. The absolute mean differences in MPF between 0.3 T and 0.5 T were 0.42% and 1.70% in white and gray matter, respectively. Single-point MPF mapping using 0.3 T permanent-magnet MRI can effectively assess myelin content in neural tissue.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":" ","pages":"869-877"},"PeriodicalIF":1.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiological Physics and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12194-024-00843-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
In a 0.3 T permanent-magnet magnetic resonance imaging (MRI) system, quantifying myelin content is challenging owing to long imaging times and low signal-to-noise ratio. macromolecular proton fraction (MPF) offers a quantitative assessment of myelin in the nervous system. We aimed to demonstrate the practical feasibility of MPF mapping in the brain using a 0.3 T MRI. Both 0.3 T and 3.0 T MRI systems were used. The MPF-mapping protocol used a standard 3D fast spoiled gradient-echo sequence based on the single-point reference method. Proton density, T1, and magnetization transfer-weighted images were obtained from a protein phantom at 0.3 T and 3.0 T to calculate MPF maps. MPF was measured in all phantom sections to assess its relationship to protein concentration. We acquired MPF maps for 16 and 8 healthy individuals at 0.3 T and 3.0 T, respectively, measuring MPF in nine brain tissues. Differences in MPF between 0.3 T and 3.0 T, and between 0.3 T and previously reported MPF at 0.5 T, were investigated. Pearson's correlation coefficient between protein concentration and MPF at 0.3 T and 3.0 T was 0.92 and 0.90, respectively. The 0.3 T MPF of brain tissue strongly correlated with 3.0 T MPF and literature values measured at 0.5 T. The absolute mean differences in MPF between 0.3 T and 0.5 T were 0.42% and 1.70% in white and gray matter, respectively. Single-point MPF mapping using 0.3 T permanent-magnet MRI can effectively assess myelin content in neural tissue.
在 0.3 T 永磁磁共振成像(MRI)系统中,由于成像时间长、信噪比低,对髓鞘含量进行量化具有挑战性。我们的目的是利用 0.3 T MRI 演示脑中 MPF 图谱的实际可行性。我们同时使用了 0.3 T 和 3.0 T MRI 系统。MPF 测绘方案使用了基于单点参考方法的标准三维快速破坏梯度回波序列。在 0.3 T 和 3.0 T 下从蛋白质模型中获取质子密度、T1 和磁化传递加权图像,以计算 MPF 图。测量了所有模型切片的 MPF,以评估其与蛋白质浓度的关系。我们分别在 0.3 T 和 3.0 T 下获取了 16 名和 8 名健康人的 MPF 图,测量了九个脑组织的 MPF。我们研究了 0.3 T 和 3.0 T 之间的 MPF 差异,以及 0.3 T 和之前报道的 0.5 T MPF 之间的差异。蛋白质浓度与 0.3 T 和 3.0 T MPF 之间的皮尔逊相关系数分别为 0.92 和 0.90。脑组织的 0.3 T MPF 与 3.0 T MPF 和 0.5 T 测量的文献值密切相关。在白质和灰质中,0.3 T 和 0.5 T MPF 的绝对平均差异分别为 0.42% 和 1.70%。使用 0.3 T 永磁磁共振成像进行单点 MPF 测绘可有效评估神经组织中的髓鞘含量。
期刊介绍:
The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.