Role of RANKL Signaling in Bone Homeostasis.

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2025-01-01 Epub Date: 2024-09-10 DOI:10.1152/physiol.00031.2024
Cristina Sobacchi, Ciro Menale, Laura Crisafulli, Francesca Ficara
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引用次数: 0

Abstract

RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway. We focus on the RANKL cytokine, whose alterations are responsible for rare and common bone diseases. We describe recent insights on the regulation of RANKL expression, which provide new hints for the pharmacological regulation of this molecule. Based on the multiple functions exerted by RANKL (within and outside the bone tissue), we advise caution regarding the potential unintended consequences of its inhibition.

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rankl信号在骨平衡中的作用。
RANKL 及其同源受体 RANK 是生理和病理状态下骨代谢的关键调节因子。在此,我们将介绍揭示这一信号通路重要作用的研究成果。我们重点关注 RANKL 细胞因子,它的改变是罕见和常见骨病的罪魁祸首。我们描述了最近对 RANKL 表达调控的深入研究,这为该分子的药理调控提供了新的线索。基于 RANKL 的多种功能(在骨组织内外),我们建议谨慎对待抑制 RANKL 可能带来的意外后果。
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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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