Dermatophagoides pteronyssinus proteins and their role in the diagnostics and management of house dust mite allergy: exploring allergenic components.

IF 1.4 4区医学 Q3 ALLERGY Postepy Dermatologii I Alergologii Pub Date : 2024-08-01 Epub Date: 2024-08-21 DOI:10.5114/ada.2024.142390

Magdalena Choina, Krzysztof Kowal, Ewa Markut-Miotła, Emilia Majsiak

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Abstract

Component-resolved diagnostics enables the detection of allergen-specific immunoglobulins E (asIgE) to house dust mite (HDM) proteins, which may help clinicians to face the difficulties in diagnostics of HDM allergy. Currently, almost 40 proteins of Dermatophagoides species, that are able to bind asIgE, have been identified, and this number will certainly increase. The association between sensitisation to particular molecules and allergy symptoms is extensively studied. This investigation enables us to identify HDM molecules that promote respiratory, skin, or food allergies, and it could help us predict the possible course of allergic diseases. The individual repertoire of asIgE improves our understanding of immunological response, which underlies allergy symptoms, and helps to form individual therapeutic regimens. This review provides clinicians with information on Dermatophagoides pteronyssinus proteins available in commercial arrays, and their role in the diagnostics and management of HDM allergy.

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Dermatophagoides pteronyssinus 蛋白质及其在诊断和治疗屋尘螨过敏症中的作用：探索过敏原成分。

成分分辨诊断法可以检测到与屋尘螨（HDM）蛋白结合的过敏原特异性免疫球蛋白 E（asIgE），这可以帮助临床医生解决诊断 HDM 过敏症的难题。目前，已发现近 40 种能与 asIgE 结合的皮螨蛋白，而且这一数字肯定还会增加。对特定分子的致敏与过敏症状之间的关联进行了广泛研究。这项研究使我们能够确定促进呼吸道、皮肤或食物过敏的 HDM 分子，并帮助我们预测过敏性疾病的可能病程。asIgE的个体化研究有助于我们更好地了解过敏症状背后的免疫反应，并有助于制定个体化的治疗方案。本综述为临床医生提供了有关商用阵列中可用的 Dermatophagoides pteronyssinus 蛋白的信息，以及它们在 HDM 过敏症的诊断和治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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