Clinical utility of multi-row spiral CT in diagnosing hepatic nodular lesions, gastric cancer, and Crohn's disease: a comprehensive meta-analysis.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/SREJ4505
Ming Xu, Yinyun Chen, Dan Liu, Lile Wang, Minghao Wu
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Abstract

A retrieval of relevant literature on hepatic nodular lesions, gastric cancer (GC), and Crohn's disease (CD) was conducted from Chinese and English databases. Meta-analysis was performed using Review Manager 5.4 software and the MIDAS package in Stata 18.0. Results from 11 studies comprising 1847 patients were synthesized. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with 95% confidence intervals were: 0.91 (0.84-0.95), 0.73 (0.65-0.79), 3.30 (2.60-4.30), 0.13 (0.07-0.23), and 26.00 (12.00-53.00), respectively. Significant statistical heterogeneity was found in sensitivity and specificity (P<0.05), with specificity heterogeneity originating from n, type, and mode (P<0.05). Sensitivity and specificity for n, type, object, and mode were non-heterogeneous (P>0.05). The combined AUC from SROC curve analysis of the 11 studies was 0.85. Deeks' funnel plot asymmetry test yielded a p-value of 0.01, indicating potential bias across studies in the diagnostic odds ratio funnel plot. Fagan's nomogram demonstrated that using CT for diagnostic modeling increased the post-test probability of correctly diagnosing hepatic nodular lesions, GC, and CD from 50.00% to 77.00%. Overall, multi-detector CT shows good diagnostic value for hepatic nodular lesions, GC, and CD, supporting its clinical flexibility based on patient-specific considerations.

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多排螺旋 CT 在诊断肝结节性病变、胃癌和克罗恩病方面的临床实用性:一项综合荟萃分析。
从中英文数据库中检索了有关肝结节病变、胃癌(GC)和克罗恩病(CD)的相关文献。使用Review Manager 5.4软件和Stata 18.0中的MIDAS软件包进行了元分析。综合了 11 项研究、1847 名患者的结果。汇总的敏感性、特异性、阳性似然比、阴性似然比和诊断几率比(95% 置信区间)分别为分别为 0.91(0.84-0.95)、0.73(0.65-0.79)、3.30(2.60-4.30)、0.13(0.07-0.23)和 26.00(12.00-53.00)。在灵敏度和特异性方面发现了显著的统计学异质性(P0.05)。对 11 项研究进行 SROC 曲线分析得出的综合 AUC 为 0.85。Deeks的漏斗图不对称检验得出的P值为0.01,表明诊断几率比漏斗图中各研究之间可能存在偏差。Fagan 的提名图显示,使用 CT 进行诊断建模可将正确诊断肝结节性病变、GC 和 CD 的检测后概率从 50.00% 提高到 77.00%。总体而言,多探头 CT 对肝结节性病变、GC 和 CD 显示出良好的诊断价值,支持其基于患者特异性考虑的临床灵活性。
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