Pharmacological tightrope: risperidone's balancing act in cri du chat syndrome.

Quamaine Bond, Himanshu Agrawal
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Abstract

Background: This case report describes an infrequent instance of risperidone-induced hyperprolactinemia in a 23-year-old nonverbal male with cri du chat syndrome.

Case presentation: Risperidone, initially prescribed to manage aggressive behaviors, resulted in bilateral gynecomastia and hyperprolactinemia. Tapering of risperidone led to resolution of these symptoms but exposed a resurgence of excessive masturbation, a behavior previously suppressed by the medication. Reintroduction of risperidone controlled this behavior, suggesting its potential role in managing compulsive behaviors in this population.

Conclusion: This case underscores the complex interaction between pharmacological treatment and behavioral symptoms in neurodevelopmental disorders. It highlights the necessity for meticulous monitoring and individualized treatment approaches in managing such cases.

Case presentation: Initially prescribed for managing aggressive behaviors, Risperidone led to bilateral gynecomastia and hyperprolactinemia in the patient. Gradual tapering of Risperidone alleviated these symptoms but unveiled a resurgence of excessive masturbation, a behavior previously suppressed by the medication. Reintroduction of Risperidone mitigated this behavior, suggesting its potential efficacy in managing compulsive tendencies in this demographic.

Conclusion: This case highlights the intricate interplay between pharmacological interventions and the complex behavioral manifestations of neurodevelopmental disorders. It underscores the importance of vigilant monitoring and personalized treatment strategies in such cases.

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药理学走钢丝:利培酮在啼哭综合征中的平衡作用。
背景:本病例报告描述了一名患有啼哭综合征的 23 岁非语言男性因利培酮诱发高泌乳素血症的罕见病例:利培酮最初用于控制攻击行为,结果导致双侧妇科肿瘤和高泌乳素血症。减少利培酮用量后,这些症状得到缓解,但过度手淫的症状再次出现,而这种行为之前一直受到药物抑制。重新使用利培酮后,这种行为得到控制,这表明利培酮在控制这类患者的强迫行为方面具有潜在作用:本病例强调了神经发育障碍患者的药物治疗与行为症状之间复杂的相互作用。结论:本病例强调了药物治疗与神经发育障碍患者行为症状之间复杂的相互作用,突出了在管理此类病例时进行细致监测和采取个性化治疗方法的必要性:利培酮最初用于控制攻击行为,但却导致患者出现双侧妇科肿大和高泌乳素血症。逐渐减量利培酮缓解了这些症状,但过度手淫的症状再次出现,而这种行为之前一直受到药物的抑制。重新使用利培酮后,这种行为有所缓解,这表明利培酮在控制这一人群的强迫倾向方面具有潜在疗效:本病例凸显了药物干预与神经发育障碍复杂行为表现之间错综复杂的相互作用。结论:本病例突出了药物干预与神经发育障碍的复杂行为表现之间错综复杂的相互作用,强调了对此类病例进行警惕性监测和采取个性化治疗策略的重要性。
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