Global Burden of Inflammatory Bowel Disease Among Children and Adolescents: A Comprehensive Analysis (1990-2019).

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Journal of Public Health Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.3389/ijph.2024.1607440

Xuejie Chen, Xin Xiang, Xiaofei Fan, Weitong Xia, Yi Xiao, Sidan Wang, Shuyu Ye, Meng Kang, Fangmin Jing, Xing Wu, Yang Chen

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Abstract

Objective: We summarize the global, regional, and national burden of inflammatory bowel disease (IBD) in children and adolescents from 1990 to 2019.

Methods: Based on the Global Burden of Disease Study 2019, the data of IBD in children and adolescents were analyzed by sex, age, year, and location. Joinpoint analysis was applied to assess the temporal trend of the disease burden.

Results: From 1990 to 2019, the incidence of IBD in children and adolescents increased by 22.8%, from 20,897.42 to 25,658.55 cases, especially in high SDI region. During the same period, the DALY numbers decreased by 53.5%, from 243,081.06 to 113,119.86, with all SDI regions experiencing a clear drop in DALYs except high SDI regions. In 2019, early-onset IBD incidence and DALY numbers were reported at 2,053.52 (95% UI: 1,575.62 to 2,677.49) and 73,797.46 (95% UI: 43,655.86 to 105,998.63), respectively.

Conclusion: Early-onset IBD in children and adolescents remains a significant global health concern. The disease burden has not improved in developed countries over the past 30 years, highlighting the need for targeted interventions.

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全球儿童和青少年炎症性肠病负担：综合分析（1990-2019 年）》。

摘要我们总结了 1990 年至 2019 年全球、地区和国家儿童和青少年炎症性肠病（IBD）的负担情况：方法：根据《2019 年全球疾病负担研究》，按性别、年龄、年份和地区对儿童和青少年的 IBD 数据进行了分析。结果：从 1990 年到 2019 年，儿童和青少年肠道疾病的发病率呈上升趋势：从 1990 年到 2019 年，儿童和青少年 IBD 发病率增加了 22.8%，从 20897.42 例增加到 25658.55 例，尤其是在 SDI 高的地区。同期，残疾调整寿命年数下降了 53.5%，从 243,081.06 例降至 113,119.86 例，除高 SDI 地区外，所有 SDI 地区的残疾调整寿命年数均有明显下降。2019年，早发IBD发病率和残疾调整寿命年数分别为2,053.52（95% UI：1,575.62至2,677.49）和73,797.46（95% UI：43,655.86至105,998.63）：结论：儿童和青少年中的早发性肠道疾病仍然是全球关注的重大健康问题。在过去的 30 年中，发达国家的疾病负担并没有得到改善，这凸显了有针对性干预措施的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

2.20%

发文量

269

审稿时长

12 months

期刊介绍： The International Journal of Public Health publishes scientific articles relevant to global public health, from different countries and cultures, and assembles them into issues that raise awareness and understanding of public health problems and solutions. The Journal welcomes submissions of original research, critical and relevant reviews, methodological papers and manuscripts that emphasize theoretical content. IJPH sometimes publishes commentaries and opinions. Special issues highlight key areas of current research. The Editorial Board''s mission is to provide a thoughtful forum for contemporary issues and challenges in global public health research and practice.