Osseointegration and Histopathological Evaluation of Titanium–Titanium Diboride Composite Compared to Pure Titanium Implant Materials Prepared by Powder Metallurgy (In Vivo Study)

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-09-24 DOI:10.1002/jbm.b.35490
Ali Mohammad Ali Aljafery, Abdalbseet A. Fatalla, Julfikar Haider
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Abstract

The efficacy and osseointegration rate of an implant depend on its biocompatibility. Modern implantology seeks fast and reliable osseointegration, which is essential for clinical success. The objective of this research was to assess the osseointegration and biocompatibility of a titanium–titanium diboride composite (Ti-TiB2) in rabbits in contrast to those of pure titanium (Ti). A total of 64 cylindrical implant specimens were fabricated, consisting of two sets: pure Ti (32 implants) and Ti-TiB2 composite (32 implants). In this study, two implants were implanted per tibia (left and right tibias) in 16 white male New Zealand rabbits, for a total of four implants per rabbit (4 × 16 = 64 implants). A pushout test was used to assess implant specimen-bone bonding after 2 and 6 weeks of healing. The experiment utilized five rabbits per healing phase, which means that 20 implants per time point were used for the pushout tests. (10 for pure Ti and 10 for the composite). Histology was used to examine the tissue response to biocompatibility, and histomorphometry was used to measure new bone growth at the two time points. With three rabbits per time point, 12 implants were employed for the histological analyses. After implantation, the pushout shear strength results revealed that the mean shear strength of the Ti-TiB2 implant specimens (5.4 ± 0.029 MPa for 2 weeks, 7.9 ± 0.029 MPa for 6 weeks) was statistically greater (p < 0.0001) than that of the pure Ti implant specimens (5.1 ± 0.015 MPa for 2 weeks, 6.6 ± 0.047 MPa for 6 weeks). After 2 weeks, woven bone tissues were observed around the pure titanium implants, and active osteoid tissue around the composite implants exhibited significant differences in new bone formation areas (NBFAs) (0.54 ± 0.004 mm2 for Ti and 0.65 ± 0.003 mm2 for the composite). After 6 weeks, there was new bone formation with osteocytes around the pure titanium implants (NBFA of 2.44 mm2) and osteoid maturation with the observation of reversal lines around the composite implants (NBFA of 2.89 mm2). The developed Ti-TiB2 material was biocompatible and demonstrated superior bone growth compared to that of the pure Ti materials after 2 and 6 weeks.

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与粉末冶金法制备的纯钛种植体材料相比,二硼化钛-钛复合材料的骨结合和组织病理学评估(体内研究)。
种植体的功效和骨结合率取决于其生物相容性。现代种植学追求快速可靠的骨结合,这对临床成功至关重要。本研究旨在评估二硼化钛(Ti-TiB2)复合材料与纯钛(Ti)复合材料在兔子体内的骨结合和生物相容性。共制作了 64 个圆柱形种植体样本,包括两组:纯钛(32 个种植体)和钛-钛二化物复合材料(32 个种植体)。在这项研究中,16 只白色雄性新西兰兔的左右胫骨各植入两个植入体,每只兔共植入四个植入体(4 × 16 = 64 个植入体)。在愈合 2 周和 6 周后,采用推出试验评估植入物试样与骨的粘合情况。实验在每个愈合阶段使用 5 只兔子,即每个时间点使用 20 个种植体进行推出试验。(纯钛 10 个,复合材料 10 个)。组织学用于检查组织对生物相容性的反应,组织形态计量学用于测量两个时间点的新骨生长。每个时间点有三只兔子,共使用了 12 个种植体进行组织学分析。植入后,推出剪切强度结果显示,Ti-TiB2 植入体试样的平均剪切强度(2 周为 5.4 ± 0.029 MPa,6 周为 7.9 ± 0.029 MPa)在统计学上更高(Ti 为 p 2,复合材料为 0.65 ± 0.003 mm2)。6 周后,纯钛种植体周围有新骨形成,并伴有骨细胞(NBFA 为 2.44 mm2),复合材料种植体周围有骨成熟,并观察到反转线(NBFA 为 2.89 mm2)。所开发的钛-钛硼材料具有良好的生物相容性,与纯钛材料相比,2 周和 6 周后的骨生长效果更佳。
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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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