Janaína Oliveira de Araújo RD , Maria Karolainy do Nascimento RD , Amanda de Sousa Rebouças MSc, RD , Galtieri Otávio Cunha de Medeiros MSc , Jarson Pedro da Costa Pereira MSc , Ana Paula Trussardi Fayh RD, PhD
{"title":"Differences in muscle composition and functionality: Exploring CT anatomical points and SARC-F components","authors":"Janaína Oliveira de Araújo RD , Maria Karolainy do Nascimento RD , Amanda de Sousa Rebouças MSc, RD , Galtieri Otávio Cunha de Medeiros MSc , Jarson Pedro da Costa Pereira MSc , Ana Paula Trussardi Fayh RD, PhD","doi":"10.1016/j.nut.2024.112564","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Our study aimed to 1) investigate the differences of muscle parameters in relation to each SARC-F component/question; and 2) explore the relationship between SARC-F score with these muscle parameters using various landmarks derived from computed tomography (CT) scans of patients with cancer.</div></div><div><h3>Methods</h3><div>This study is a cross-sectional analysis of a cohort comprised of consecutive patients with cancer, displaying CT scans. SARC-F questionnaire was utilized as a proxy for muscle functionality, with a score ≥4 indicating a poor status. Muscle assessment via CT measurements was performed using single cross-sectional images at the level of the third lumbar vertebrae (L3) in the abdominal region, the thigh region, and the total gluteal region at the level of the second sacral vertebrae. Skeletal muscle (SM) cross-sectional area, SM index (normalized to height<sup>2</sup>), and SM radiodensity (SMD) were evaluated for all anatomical landmarks.</div></div><div><h3>Results</h3><div>A total of 128 patients were included in this analysis (53.1% females, 61.7% older adults). Patients with SARC-F scores ≥4 demonstrated significantly lower values of SMD across all landmarks assessed. Those reporting difficulties related to strength (<strong><em>P</em></strong> = 0.039), requiring assistance in walking (<strong><em>P</em></strong> = 0.033), and climbing stairs (<strong><em>P</em></strong> = 0.012) exhibited significantly lower SMD values at the L3 landmark. At gluteus and thigh levels, only patients experiencing difficulty climbing stairs (<strong><em>P</em></strong> = 0.012) showed significantly lower values of SMD. Only SMD at gluteus level was independently associated with SARC-F score (<em>β</em><sub>adjusted</sub> –0.09, 95% CI –0.16 to –0.02).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that individuals with poor muscle composition may experience a higher risk of sarcopenia/poor muscle functionality.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"128 ","pages":"Article 112564"},"PeriodicalIF":3.2000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0899900724002132","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
Our study aimed to 1) investigate the differences of muscle parameters in relation to each SARC-F component/question; and 2) explore the relationship between SARC-F score with these muscle parameters using various landmarks derived from computed tomography (CT) scans of patients with cancer.
Methods
This study is a cross-sectional analysis of a cohort comprised of consecutive patients with cancer, displaying CT scans. SARC-F questionnaire was utilized as a proxy for muscle functionality, with a score ≥4 indicating a poor status. Muscle assessment via CT measurements was performed using single cross-sectional images at the level of the third lumbar vertebrae (L3) in the abdominal region, the thigh region, and the total gluteal region at the level of the second sacral vertebrae. Skeletal muscle (SM) cross-sectional area, SM index (normalized to height2), and SM radiodensity (SMD) were evaluated for all anatomical landmarks.
Results
A total of 128 patients were included in this analysis (53.1% females, 61.7% older adults). Patients with SARC-F scores ≥4 demonstrated significantly lower values of SMD across all landmarks assessed. Those reporting difficulties related to strength (P = 0.039), requiring assistance in walking (P = 0.033), and climbing stairs (P = 0.012) exhibited significantly lower SMD values at the L3 landmark. At gluteus and thigh levels, only patients experiencing difficulty climbing stairs (P = 0.012) showed significantly lower values of SMD. Only SMD at gluteus level was independently associated with SARC-F score (βadjusted –0.09, 95% CI –0.16 to –0.02).
Conclusions
Our findings suggest that individuals with poor muscle composition may experience a higher risk of sarcopenia/poor muscle functionality.
期刊介绍：
Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
