Pub Date : 2026-01-11DOI: 10.1016/j.nut.2026.113110
Caroline Ash, Luis E Maldonado, Tingyu Yang, Sandrah P Eckel, Claudia Toledo-Corral, Jill Johnston, Shohreh Farzan, Genevieve Dunton, Carrie Breton, Theresa Bastain
Background: Poor dietary intake has been linked to depression during pregnancy, but little research has examined this in Hispanic populations.
Objective: We examined third-trimester associations of study-derived dietary patterns with odds of prenatal depression and depressive symptoms in pregnant, low-income Hispanic women.
Methods: Participants (N = 587) were drawn from the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort in Los Angeles, CA. Diet was assessed using a 24-h recall tool. Women were assigned quartile rankings based on adherence to two previously derived dietary patterns: vegetables, oils, and fruit (VOF; healthier) and solid fats, refined grains, and cheese (SRC; less healthy). Depressive symptoms were defined using the Center for Epidemiological Studies-Depression Scale score, and a dichotomized depression outcome was defined as Center for Epidemiological Studies-Depression Scale scores ≥16.
Results: Eighteen percent of participants were classified as depressed at the third-trimester visit. Women with the greatest adherence to the healthier dietary pattern (VOF) had 59% lower odds of depression (OR = 0.41, 95% CI: 0.19, 0.86) relative to women with the lowest adherence to this dietary pattern, after adjustment for covariates. Additionally, women with moderately high (third quartile) adherence to the VOF dietary pattern had 16.9% lower depressive symptoms (95% CI: -30.5%, -0.8%) compared with women with the lowest VOF adherence. Women with the highest VOF adherence had similar, non-statistically significant lower depressive symptoms (Beta = -10.4%, 95% CI: -25.7%, 8.1%).
Conclusion: Our results indicate that there are important relationships between a healthy diet and lower depression in late pregnancy, and suggest that nutritional counseling and improved neighborhood access to healthy food may be important for maternal mental health.
{"title":"Third-trimester diet and prenatal depression in the MADRES cohort.","authors":"Caroline Ash, Luis E Maldonado, Tingyu Yang, Sandrah P Eckel, Claudia Toledo-Corral, Jill Johnston, Shohreh Farzan, Genevieve Dunton, Carrie Breton, Theresa Bastain","doi":"10.1016/j.nut.2026.113110","DOIUrl":"https://doi.org/10.1016/j.nut.2026.113110","url":null,"abstract":"<p><strong>Background: </strong>Poor dietary intake has been linked to depression during pregnancy, but little research has examined this in Hispanic populations.</p><p><strong>Objective: </strong>We examined third-trimester associations of study-derived dietary patterns with odds of prenatal depression and depressive symptoms in pregnant, low-income Hispanic women.</p><p><strong>Methods: </strong>Participants (N = 587) were drawn from the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort in Los Angeles, CA. Diet was assessed using a 24-h recall tool. Women were assigned quartile rankings based on adherence to two previously derived dietary patterns: vegetables, oils, and fruit (VOF; healthier) and solid fats, refined grains, and cheese (SRC; less healthy). Depressive symptoms were defined using the Center for Epidemiological Studies-Depression Scale score, and a dichotomized depression outcome was defined as Center for Epidemiological Studies-Depression Scale scores ≥16.</p><p><strong>Results: </strong>Eighteen percent of participants were classified as depressed at the third-trimester visit. Women with the greatest adherence to the healthier dietary pattern (VOF) had 59% lower odds of depression (OR = 0.41, 95% CI: 0.19, 0.86) relative to women with the lowest adherence to this dietary pattern, after adjustment for covariates. Additionally, women with moderately high (third quartile) adherence to the VOF dietary pattern had 16.9% lower depressive symptoms (95% CI: -30.5%, -0.8%) compared with women with the lowest VOF adherence. Women with the highest VOF adherence had similar, non-statistically significant lower depressive symptoms (Beta = -10.4%, 95% CI: -25.7%, 8.1%).</p><p><strong>Conclusion: </strong>Our results indicate that there are important relationships between a healthy diet and lower depression in late pregnancy, and suggest that nutritional counseling and improved neighborhood access to healthy food may be important for maternal mental health.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113110"},"PeriodicalIF":3.0,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1016/j.nut.2026.113105
Haleema Shabir, James Evans
Background: Proton beam therapy (PBT) is a novel treatment for children with certain cancers. It requires meticulous planning tailored to a child's body contour, shape, and size. Weight maintenance is essential throughout therapy to avoid unnecessary treatment replanning. Despite the specificity of PBT, gastrointestinal side effects can still occur and negatively impact children's nutritional intake.
Aim: Examine the use of dietetic interventions, weight change, and calorie intake of children during PBT.
Methods: A retrospective study at a single center was undertaken. Nutritional outcomes were examined at baseline, wk-1, wk-3, wk-6 of PBT, including changes in weight Z-score and calorie intake from oral and tube feeding routes. The impact of children's disease type on the need for tube feeding, weight change, and calorie intake was analyzed.
Results: One hundred and twelve children received PBT, of which 26% (29/112) did not require dietetic intervention and were excluded, but 74% (83/112) did and were included. Of these, 51% maintained their oral intake exclusively, 28% had a prophylactic gastrostomy (including 60%, 15/25 of those with head and neck cancer), 16% a prophylactic nasogastric tube (including 23%, 11/48 of those with neurological disease). From baseline to wk-6, 80% maintained their weight within 5% loss/gain. The mean weight Z-score significantly reduced from 0.22 to 0.10 (P = 0.038), as did oral calorie intake (P = 0.003). Calorie intake from tube feeding significantly increased (P = 0.006).
Conclusions: Nutritional support ensured that most children maintained a stable weight during PBT. A high prevalence of children required tube feeding via a gastrostomy or nasogastric tube as their oral intake declined.
{"title":"A single-center retrospective study investigating use of dietetic interventions and changes in nutritional intake and weight in children receiving proton beam therapy.","authors":"Haleema Shabir, James Evans","doi":"10.1016/j.nut.2026.113105","DOIUrl":"https://doi.org/10.1016/j.nut.2026.113105","url":null,"abstract":"<p><strong>Background: </strong>Proton beam therapy (PBT) is a novel treatment for children with certain cancers. It requires meticulous planning tailored to a child's body contour, shape, and size. Weight maintenance is essential throughout therapy to avoid unnecessary treatment replanning. Despite the specificity of PBT, gastrointestinal side effects can still occur and negatively impact children's nutritional intake.</p><p><strong>Aim: </strong>Examine the use of dietetic interventions, weight change, and calorie intake of children during PBT.</p><p><strong>Methods: </strong>A retrospective study at a single center was undertaken. Nutritional outcomes were examined at baseline, wk-1, wk-3, wk-6 of PBT, including changes in weight Z-score and calorie intake from oral and tube feeding routes. The impact of children's disease type on the need for tube feeding, weight change, and calorie intake was analyzed.</p><p><strong>Results: </strong>One hundred and twelve children received PBT, of which 26% (29/112) did not require dietetic intervention and were excluded, but 74% (83/112) did and were included. Of these, 51% maintained their oral intake exclusively, 28% had a prophylactic gastrostomy (including 60%, 15/25 of those with head and neck cancer), 16% a prophylactic nasogastric tube (including 23%, 11/48 of those with neurological disease). From baseline to wk-6, 80% maintained their weight within 5% loss/gain. The mean weight Z-score significantly reduced from 0.22 to 0.10 (P = 0.038), as did oral calorie intake (P = 0.003). Calorie intake from tube feeding significantly increased (P = 0.006).</p><p><strong>Conclusions: </strong>Nutritional support ensured that most children maintained a stable weight during PBT. A high prevalence of children required tube feeding via a gastrostomy or nasogastric tube as their oral intake declined.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113105"},"PeriodicalIF":3.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.nut.2026.113102
Eric Bartholomae, Camila Nadalet, Carol S Johnston
Objectives: Plant-based diets are rising in popularity due to their health and environmental benefits. Vegan diets are a strict plant-based diet plan that excludes all animal foods, and reports suggest that a considerable portion of habitual vegans do not consume the daily recommended amount of protein.
Methods: This study utilized a cross-sectional study design to examine functional and structural markers of protein status (e.g., lean body mass and muscle strength) in healthy, lightly active women who habitually consumed a vegan (>1 y) or omnivore diet. Participants were matched by age, weight, and body mass index. Participants completed health and diet questionnaires and a physical activity assessment. Lean body mass was measured using dual-energy x-ray absorptiometry. Dynamometer testing was used to measure hand grip and leg strength. Inferential statistics and correlational analyses were used to examine differences between diet groups.
Results: Protein intakes and lean body mass were significantly lower for the vegan participants compared to those eating meat (-44% and -8%, respectively). Although hand grip strength was similar between diet groups, several indicators of leg strength were 14% to 15% lower in the vegan group compared to the omnivore group (P < 0.05). Correlates of strength varied by diet group: several strength markers were significantly correlated to lean mass in the vegan diet group, whereas strength and dietary protein were correlated in the omnivore diet group.
Conclusion: These data suggest that functional indicators of body protein status may be adversely impacted by long-term adherence to vegan diets in young adult women.
{"title":"Influences of vegan status on protein intake, lean body mass, and strength in lightly active, young women: A cross-sectional study.","authors":"Eric Bartholomae, Camila Nadalet, Carol S Johnston","doi":"10.1016/j.nut.2026.113102","DOIUrl":"https://doi.org/10.1016/j.nut.2026.113102","url":null,"abstract":"<p><strong>Objectives: </strong>Plant-based diets are rising in popularity due to their health and environmental benefits. Vegan diets are a strict plant-based diet plan that excludes all animal foods, and reports suggest that a considerable portion of habitual vegans do not consume the daily recommended amount of protein.</p><p><strong>Methods: </strong>This study utilized a cross-sectional study design to examine functional and structural markers of protein status (e.g., lean body mass and muscle strength) in healthy, lightly active women who habitually consumed a vegan (>1 y) or omnivore diet. Participants were matched by age, weight, and body mass index. Participants completed health and diet questionnaires and a physical activity assessment. Lean body mass was measured using dual-energy x-ray absorptiometry. Dynamometer testing was used to measure hand grip and leg strength. Inferential statistics and correlational analyses were used to examine differences between diet groups.</p><p><strong>Results: </strong>Protein intakes and lean body mass were significantly lower for the vegan participants compared to those eating meat (-44% and -8%, respectively). Although hand grip strength was similar between diet groups, several indicators of leg strength were 14% to 15% lower in the vegan group compared to the omnivore group (P < 0.05). Correlates of strength varied by diet group: several strength markers were significantly correlated to lean mass in the vegan diet group, whereas strength and dietary protein were correlated in the omnivore diet group.</p><p><strong>Conclusion: </strong>These data suggest that functional indicators of body protein status may be adversely impacted by long-term adherence to vegan diets in young adult women.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113102"},"PeriodicalIF":3.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.nut.2025.113091
Xuemei Li, Qian You
{"title":"Response to the Comment on: \"Comparison of ChatGPT-3.5, ChatGPT-4.0 and DeepSeek in generating dietary plans for patients with chronic kidney disease: A focus on nutritional accuracy and dietary inflammation\".","authors":"Xuemei Li, Qian You","doi":"10.1016/j.nut.2025.113091","DOIUrl":"https://doi.org/10.1016/j.nut.2025.113091","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":" ","pages":"113091"},"PeriodicalIF":3.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.nut.2026.113100
Meiling Liu PhD , Sunmin Park PhD, RD
Objectives
Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS).
Methods
A genome-wide association study was conducted using UK Biobank data from 93,402 participants aged ≥65 y with bioelectrical impedance analysis results, including 14 076 with low-LSMI. Low-LSMI was defined as <5.7 kg/m² for men and <4.9 kg/m² for women based on EWGSOP2 (European Working Group on Sarcopenia in Older People 2) criteria. Secondary analyses included gene set enrichment analysis and tissue-specific expression profiling. A PRS was developed using generalized multifactor dimensionality reduction, and molecular docking analysis evaluated nutrient–protein binding.
Results
Results: Low-LSMI prevalence was higher in men than in women (18.5% vs. 11.8%), and was associated with elevated inflammatory markers (Hs-CRP: 3.43 vs. 2.73 mg/dL in men; P < 0.001), lower serum vitamin D (49.7 vs. 53.3 ng/mL in men; P < 0.001), and paradoxically lower metabolic syndrome prevalence. The strongest genetic association was rs77530409 in IL5RA (odds ratio [OR] = 1.97, P = 6.16 × 10⁻¹⁷). An optimal 4-single-nucleotide polymorphism (SNP) PRS model (FTO rs3751814, ADAMTSL3 rs4842838, CYP4F2 rs3093198, and DPP8 rs66993805) achieved an area under the curve of 0.852. Significant gene–lifestyle interactions were observed for high-risk individuals with low protein intake (OR = 1.35), low vitamin D (OR = 1.66), high alcohol consumption (OR = 1.54), or low physical activity (OR = 1.52). Molecular docking showed reduced binding affinity of vitamin D3 to the ADAMTSL3-mutated variant (661Leu; -8.7 kcal/mol) relative to the wild-type (Val661; -9.3 kcal/mol).
Conclusion
Conclusions: The 4-SNP PRS, combined with lifestyle assessment through gene–lifestyle interaction analysis, provides a tool for early risk stratification of muscle loss in older adults, with molecular evidence supporting personalized nutritional interventions.
目的:下肢骨骼肌质量是维持老年人身体功能所必需的,是肌肉减少症的早期指标。本研究旨在描述下肢骨骼肌指数(low-下肢骨骼肌指数)的多基因结构,确定潜在的生物学机制,并建立多基因风险评分(PRS)。方法利用英国生物银行93,402名年龄≥65岁的参与者的数据进行全基因组关联研究,并进行生物电阻抗分析结果,其中包括14076名低lsmi患者。根据EWGSOP2(欧洲老年人肌肉减少症工作组2)标准,低lsmi被定义为男性5.7 kg/m²,女性4.9 kg/m²。二级分析包括基因集富集分析和组织特异性表达谱。采用广义多因子降维方法建立了PRS,并通过分子对接分析对营养蛋白结合进行了评价。结果:低lsmi患病率男性高于女性(18.5% vs. 11.8%),并且与炎症标志物升高(男性Hs-CRP: 3.43 vs. 2.73 mg/dL; P < 0.001)、血清维生素D降低(男性49.7 vs. 53.3 ng/mL; P < 0.001)以及代谢综合征患病率降低相关。最强的遗传关联是rs77530409在IL5RA中(优势比[OR] = 1.97, P = 6.16 × 10⁻¹⁷)。最理想的4-单核苷酸多态性(SNP) PRS模型(FTO rs3751814、ADAMTSL3 rs4842838、CYP4F2 rs3093198、DPP8 rs66993805)曲线下面积为0.852。在低蛋白质摄入量(OR = 1.35)、低维生素D (OR = 1.66)、高酒精摄入量(OR = 1.54)或低体力活动(OR = 1.52)的高危人群中,观察到显著的基因-生活方式相互作用。分子对接显示,与野生型(Val661, -9.3 kcal/mol)相比,维生素D3与adamtsl3突变变体(661Leu, -8.7 kcal/mol)的结合亲和力降低。结论:4-SNP PRS结合基因-生活方式相互作用分析的生活方式评估,为老年人肌肉损失的早期风险分层提供了工具,并有分子证据支持个性化营养干预。
{"title":"Polygenic risk score for lower limb skeletal muscle mass and its interaction with protein and vitamin D intake in older adults","authors":"Meiling Liu PhD , Sunmin Park PhD, RD","doi":"10.1016/j.nut.2026.113100","DOIUrl":"10.1016/j.nut.2026.113100","url":null,"abstract":"<div><h3>Objectives</h3><div>Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS).</div></div><div><h3>Methods</h3><div>A genome-wide association study was conducted using UK Biobank data from 93,402 participants aged ≥65 y with bioelectrical impedance analysis results, including 14 076 with low-LSMI. Low-LSMI was defined as <5.7 kg/m² for men and <4.9 kg/m² for women based on EWGSOP2 (European Working Group on Sarcopenia in Older People 2) criteria. Secondary analyses included gene set enrichment analysis and tissue-specific expression profiling. A PRS was developed using generalized multifactor dimensionality reduction, and molecular docking analysis evaluated nutrient–protein binding.</div></div><div><h3>Results</h3><div>Results: Low-LSMI prevalence was higher in men than in women (18.5% vs. 11.8%), and was associated with elevated inflammatory markers (Hs-CRP: 3.43 vs. 2.73 mg/dL in men; <em>P</em> < 0.001), lower serum vitamin D (49.7 vs. 53.3 ng/mL in men; <em>P</em> < 0.001), and paradoxically lower metabolic syndrome prevalence. The strongest genetic association was rs77530409 in <em>IL5RA</em> (odds ratio [OR] = 1.97, <em>P</em> = 6.16 × 10⁻¹⁷). An optimal 4-single-nucleotide polymorphism (SNP) PRS model (<em>FTO</em> rs3751814, <em>ADAMTSL3</em> rs4842838, <em>CYP4F2</em> rs3093198, and <em>DPP8</em> rs66993805) achieved an area under the curve of 0.852. Significant gene–lifestyle interactions were observed for high-risk individuals with low protein intake (OR = 1.35), low vitamin D (OR = 1.66), high alcohol consumption (OR = 1.54), or low physical activity (OR = 1.52). Molecular docking showed reduced binding affinity of vitamin D3 to the ADAMTSL3-mutated variant (661Leu; -8.7 kcal/mol) relative to the wild-type (Val661; -9.3 kcal/mol).</div></div><div><h3>Conclusion</h3><div>Conclusions: The 4-SNP PRS, combined with lifestyle assessment through gene–lifestyle interaction analysis, provides a tool for early risk stratification of muscle loss in older adults, with molecular evidence supporting personalized nutritional interventions.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113100"},"PeriodicalIF":3.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.nut.2026.113101
Isabela Solar, Maria Eduarda Martelli, Vinícius Ferreira Santos, Marina Maintinguer Norde, Lício Augusto Velloso, Bruno Geloneze, Ana Carolina Junqueira Vasques
Brown adipose tissue (BAT) activation increases energy expenditure and is associated with reduced body adiposity and improved cardiometabolic health. Therefore, we hypothesized that anthropometric parameters, particularly those reflecting central adiposity, could serve as indirect and straightforward markers for screening BAT activity. We evaluated the performance of anthropometric indicators, such as body mass index (BMI), waist circumference (WC), neck circumference (NC), sagittal abdominal diameter (SAD), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck-to-height ratio (NHtR), SAD-to-height ratio (SADHtR) and body roundness index (BRI), for screening of BAT activity (assessed by infrared thermography) in 122 adult women exposed to cold (for 2 h in an 18°C room), considering visceral adipose tissue (VAT) measured by dual-energy X-ray absorptiometry (DXA) as the harmful indicator of abdominal adiposity. Using multiple linear regression adjusted for age and physical activity level, and receiver operating characteristic (ROC) curves, we found that BMI, SAD, WC, and WHtR were the best indirect screeners of BAT activity, performing as well as VAT (p > 0.05 for all). These indicators may serve as practical proxies of BAT activity, potentially aiding in the development of strategies for metabolic disease intervention and prevention.
{"title":"Simple anthropometric indicators compared with DXA-assessed visceral adiposity for screening brown adipose tissue activity in adult women.","authors":"Isabela Solar, Maria Eduarda Martelli, Vinícius Ferreira Santos, Marina Maintinguer Norde, Lício Augusto Velloso, Bruno Geloneze, Ana Carolina Junqueira Vasques","doi":"10.1016/j.nut.2026.113101","DOIUrl":"https://doi.org/10.1016/j.nut.2026.113101","url":null,"abstract":"<p><p>Brown adipose tissue (BAT) activation increases energy expenditure and is associated with reduced body adiposity and improved cardiometabolic health. Therefore, we hypothesized that anthropometric parameters, particularly those reflecting central adiposity, could serve as indirect and straightforward markers for screening BAT activity. We evaluated the performance of anthropometric indicators, such as body mass index (BMI), waist circumference (WC), neck circumference (NC), sagittal abdominal diameter (SAD), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck-to-height ratio (NHtR), SAD-to-height ratio (SADHtR) and body roundness index (BRI), for screening of BAT activity (assessed by infrared thermography) in 122 adult women exposed to cold (for 2 h in an 18°C room), considering visceral adipose tissue (VAT) measured by dual-energy X-ray absorptiometry (DXA) as the harmful indicator of abdominal adiposity. Using multiple linear regression adjusted for age and physical activity level, and receiver operating characteristic (ROC) curves, we found that BMI, SAD, WC, and WHtR were the best indirect screeners of BAT activity, performing as well as VAT (p > 0.05 for all). These indicators may serve as practical proxies of BAT activity, potentially aiding in the development of strategies for metabolic disease intervention and prevention.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113101"},"PeriodicalIF":3.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.nut.2025.113089
Gil B Rosa M.D. , Ruben Francisco Ph.D. , Analiza M Silva Ph.D. , Henry C Lukaski Ph.D. , Luís B Sardinha Ph.D.
Objectives
Despite cross-sectional evidence supporting raw bioelectrical impedance analysis (BIA) parameters as informative markers of body composition in youth, their role from a longitudinal perspective remains unclear. We examined how 1-y changes in phase angle (PhA) and other raw BIA parameters were associated with changes in body components at multiple levels in children and adolescents.
Methods
In a 1-y prospective cohort investigation, including 562 healthy and on-time matured youth (51.6% females), we assessed raw BIA parameters with a phase-sensitive 50 kHz BIA device and examined body composition through dual-energy X-ray absorptiometry and related models. The association between changes in raw BIA parameters and changes in body composition by sex and peak height velocity (PHV) stage was analyzed using multiple linear regression.
Results
PhA was positively associated with changes in fat-related components, fat-free mass, extracellular water, fluids and solids, osseous minerals, and muscle tissue in females (β = 0.088–0.150; P ≤ 0.05) and with alterations in most body components in males (β = 0.098–0.300; P ≤ 0.05). Similar trends to those of males were observed in both sexes during post-PHV (females: β = 0.149–0.297; males: β = 0.185–0.352; P ≤ 0.05). Other series and parallel BIA parameters exhibited even higher explanatory power of body composition than PhA, with the magnitude of the associations depending on each raw BIA parameter, sex, and PHV stage (females: β =|0.099|–|0.429|; males: β = |0.106|–|0.706|; P ≤ 0.05). Among all raw BIA parameters, the highest associations were observed in resistance adjusted to stature (RI) (total sample and pre-PHV), parallel capacitive reactance adjusted to stature (XcpI), and capacitance (Cap) (both post-PHV).
Conclusion
PhA emerged as a modest marker of body composition dynamics in youth, particularly in males and during adolescence (post-PHV), whereas other raw BIA parameters, particularly RI, XcpI, and Cap, showed even greater promise in both sexes and across development stages.
{"title":"Changes in raw bioelectrical impedance parameters as markers of body composition in youth: A prospective cohort investigation","authors":"Gil B Rosa M.D. , Ruben Francisco Ph.D. , Analiza M Silva Ph.D. , Henry C Lukaski Ph.D. , Luís B Sardinha Ph.D.","doi":"10.1016/j.nut.2025.113089","DOIUrl":"10.1016/j.nut.2025.113089","url":null,"abstract":"<div><h3>Objectives</h3><div>Despite cross-sectional evidence supporting raw bioelectrical impedance analysis (BIA) parameters as informative markers of body composition in youth, their role from a longitudinal perspective remains unclear. We examined how 1-y changes in phase angle (PhA) and other raw BIA parameters were associated with changes in body components at multiple levels in children and adolescents.</div></div><div><h3>Methods</h3><div>In a 1-y prospective cohort investigation, including 562 healthy and on-time matured youth (51.6% females), we assessed raw BIA parameters with a phase-sensitive 50 kHz BIA device and examined body composition through dual-energy X-ray absorptiometry and related models. The association between changes in raw BIA parameters and changes in body composition by sex and peak height velocity (PHV) stage was analyzed using multiple linear regression.</div></div><div><h3>Results</h3><div>PhA was positively associated with changes in fat-related components, fat-free mass, extracellular water, fluids and solids, osseous minerals, and muscle tissue in females (<em>β</em> = 0.088–0.150; <em>P</em> ≤ 0.05) and with alterations in most body components in males (<em>β</em> = 0.098–0.300; <em>P</em> ≤ 0.05). Similar trends to those of males were observed in both sexes during post-PHV (females: <em>β</em> = 0.149–0.297; males: <em>β</em> = 0.185–0.352; <em>P</em> ≤ 0.05). Other series and parallel BIA parameters exhibited even higher explanatory power of body composition than PhA, with the magnitude of the associations depending on each raw BIA parameter, sex, and PHV stage (females: <em>β</em> =|0.099|–|0.429|; males: <em>β</em> = |0.106|–|0.706|; <em>P</em> ≤ 0.05). Among all raw BIA parameters, the highest associations were observed in resistance adjusted to stature (RI) (total sample and pre-PHV), parallel capacitive reactance adjusted to stature (XcpI), and capacitance (Cap) (both post-PHV).</div></div><div><h3>Conclusion</h3><div>PhA emerged as a modest marker of body composition dynamics in youth, particularly in males and during adolescence (post-PHV), whereas other raw BIA parameters, particularly RI, XcpI, and Cap, showed even greater promise in both sexes and across development stages.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113089"},"PeriodicalIF":3.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.nut.2025.113087
Anas Almofarreh M.D., M.P.H. , Haytham A. Sheerah M.D., Ph.D. , Ahmed Arafa M.D., Ph.D. , Tareq Moh’d M.D. , Rayan A. Tayyib M.D. , Ahad N. Yamani M.D., M.P.H. , Aidrous M. Ali M.D., M.P.H.
Background
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic gastrointestinal disorder with increasing global prevalence. Although dietary factors are increasingly implicated in IBD pathogenesis, the role of spicy food remains unclear, especially in Arab populations where such foods are commonly consumed. This study aimed to examine the association between spicy food consumption and the risk of UC and CD in an Arab population.
Methods
We conducted a case-control study at a private clinic in Saudi Arabia, involving 157 patients with UC, 226 with CD, and 390 controls. IBD was diagnosed using laboratory tests, endoscopy with biopsies, and imaging when indicated. Spicy food was defined as dishes made with chili peppers or hot sauces and was assessed using a self-administered questionnaire. Multivariable logistic regression was used to evaluate the association between spicy food intake and IBD risk, and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
Results
Daily consumption of spicy food was significantly associated with higher odds of CD (OR = 1.61; 95% CI: 1.11, 2.33), but not UC (OR = 1.03; 95% CI: 0.67, 1.60). No significant associations were observed between spicy food and IBD extent or severity.
Conclusions
In this Arab population, daily spicy food intake was positively associated with CD risk, while no association was identified for UC. Future prospective cohort studies with detailed information about spicy food types and IBD severity scores are needed to confirm our findings.
{"title":"Association between spicy food consumption and inflammatory bowel disease: A case-control study from Saudi Arabia","authors":"Anas Almofarreh M.D., M.P.H. , Haytham A. Sheerah M.D., Ph.D. , Ahmed Arafa M.D., Ph.D. , Tareq Moh’d M.D. , Rayan A. Tayyib M.D. , Ahad N. Yamani M.D., M.P.H. , Aidrous M. Ali M.D., M.P.H.","doi":"10.1016/j.nut.2025.113087","DOIUrl":"10.1016/j.nut.2025.113087","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic gastrointestinal disorder with increasing global prevalence. Although dietary factors are increasingly implicated in IBD pathogenesis, the role of spicy food remains unclear, especially in Arab populations where such foods are commonly consumed. This study aimed to examine the association between spicy food consumption and the risk of UC and CD in an Arab population.</div></div><div><h3>Methods</h3><div>We conducted a case-control study at a private clinic in Saudi Arabia, involving 157 patients with UC, 226 with CD, and 390 controls. IBD was diagnosed using laboratory tests, endoscopy with biopsies, and imaging when indicated. Spicy food was defined as dishes made with chili peppers or hot sauces and was assessed using a self-administered questionnaire. Multivariable logistic regression was used to evaluate the association between spicy food intake and IBD risk, and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</div></div><div><h3>Results</h3><div>Daily consumption of spicy food was significantly associated with higher odds of CD (OR = 1.61; 95% CI: 1.11, 2.33), but not UC (OR = 1.03; 95% CI: 0.67, 1.60). No significant associations were observed between spicy food and IBD extent or severity.</div></div><div><h3>Conclusions</h3><div>In this Arab population, daily spicy food intake was positively associated with CD risk, while no association was identified for UC. Future prospective cohort studies with detailed information about spicy food types and IBD severity scores are needed to confirm our findings.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113087"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-31DOI: 10.1016/j.nut.2025.113085
Dang Hien Ngan Nguyen, Chiao-Ming Chen, Shih-Ping Lin, Hong Nhung Lam, Chien-Tien Su, Kang Ernest Liu, Shu-Chen Lee, Sing-Chung Li
Objectives: Food and nutrient security are critical for population health and environmental sustainability. This study aimed to assess Taiwan's food and nutrient security and its alignment with the planetary health diet (PHD), integrating CO2 impact analysis.
Methods: This study introduces the Food Security Index (FSI) and Nutrient Security Index (NSI) to assess Taiwan's food and nutrient security. It also examines adherence to the PHD and uses life cycle assessment to evaluate CO₂ emissions across regions/countries, offering a comprehensive view of environmental impacts. From 2017 to 2020, the Nutrition and Health Survey in Taiwan estimated the prevalence of undernourishment (PoU) for 12 120 participants using FAO methods. Additionally, the Food Insecurity Experience Scale (FIES) was calculated for 2879 participants in 2022-23 with FAO's RM.weights package. The FSI and NSI were derived from supply-to-needs (S-Nr) and intake-to-needs (I-Nr) ratios using NAHSIT and the food balance sheet (FBS). Moreover, PHD score (PHDS) was applied to assess PHD adherence and compare CO₂ emissions across 12 regions/countries using FBS.
Results: Taiwan with PoU below 2.5% (2017-20), FIES 1.1% (2022-23). FBS showed S-Nr 0.84 for vegetables, 0.77 for fruits, and 0.47 for dairy. I-Nr for calcium was 0.56, while NAHSIT S-Nr was 0.97 for cereals/roots, 0.36 for dairy, and 0.71 for vegetables/fruits, I-Nr 0.58 for fiber, 0.56 for calcium, and 0.49 for vitamin D. Taiwan achieved the highest PHDS (48.55%), while Brazil had the lowest (31.06%). A moderate negative correlation (r = -0.413) was found between PHDS and food-related CO₂ emissions.
Conclusion: Despite high food security, targeted policies are needed to address nutrient imbalances and promote sustainable diets.
{"title":"Assessing food and nutrient security in Taiwan: Integrating sustainability and the planetary health diet.","authors":"Dang Hien Ngan Nguyen, Chiao-Ming Chen, Shih-Ping Lin, Hong Nhung Lam, Chien-Tien Su, Kang Ernest Liu, Shu-Chen Lee, Sing-Chung Li","doi":"10.1016/j.nut.2025.113085","DOIUrl":"https://doi.org/10.1016/j.nut.2025.113085","url":null,"abstract":"<p><strong>Objectives: </strong>Food and nutrient security are critical for population health and environmental sustainability. This study aimed to assess Taiwan's food and nutrient security and its alignment with the planetary health diet (PHD), integrating CO<sub>2</sub> impact analysis.</p><p><strong>Methods: </strong>This study introduces the Food Security Index (FSI) and Nutrient Security Index (NSI) to assess Taiwan's food and nutrient security. It also examines adherence to the PHD and uses life cycle assessment to evaluate CO₂ emissions across regions/countries, offering a comprehensive view of environmental impacts. From 2017 to 2020, the Nutrition and Health Survey in Taiwan estimated the prevalence of undernourishment (PoU) for 12 120 participants using FAO methods. Additionally, the Food Insecurity Experience Scale (FIES) was calculated for 2879 participants in 2022-23 with FAO's RM.weights package. The FSI and NSI were derived from supply-to-needs (S-Nr) and intake-to-needs (I-Nr) ratios using NAHSIT and the food balance sheet (FBS). Moreover, PHD score (PHDS) was applied to assess PHD adherence and compare CO₂ emissions across 12 regions/countries using FBS.</p><p><strong>Results: </strong>Taiwan with PoU below 2.5% (2017-20), FIES 1.1% (2022-23). FBS showed S-Nr 0.84 for vegetables, 0.77 for fruits, and 0.47 for dairy. I-Nr for calcium was 0.56, while NAHSIT S-Nr was 0.97 for cereals/roots, 0.36 for dairy, and 0.71 for vegetables/fruits, I-Nr 0.58 for fiber, 0.56 for calcium, and 0.49 for vitamin D. Taiwan achieved the highest PHDS (48.55%), while Brazil had the lowest (31.06%). A moderate negative correlation (r = -0.413) was found between PHDS and food-related CO₂ emissions.</p><p><strong>Conclusion: </strong>Despite high food security, targeted policies are needed to address nutrient imbalances and promote sustainable diets.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113085"},"PeriodicalIF":3.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30DOI: 10.1016/j.nut.2025.113086
Martina Abodi, Anna Comotti, Stefano Turolo, Marie-Louise Syren, Gianluca Martino Tartaglia, Niccolò Cenzato, Camilla Bertoni, Silvia Bettocchi, Carlo Virginio Agostoni, Alessandra Mazzocchi, Gregorio Paolo Milani
Objectives: Fatty acid (FA) profiling is nowadays performed from blood samples according to the research objective. Salivary FAs emerged as an innovative and non-invasive analysis providing information on dietary intake, pathological conditions, and metabolic status. However, evidence on the correlation of circulating with salivary FAs is, to our knowledge, unavailable. This pilot study aims to compare the FA profiles in saliva and blood in healthy adults, evaluating saliva as a potential surrogate matrix.
Methods: Samples of saliva, plasma, and whole blood were collected from healthy subjects in fasting (T0) and postprandial (T1) conditions. FAs were analyzed using gas chromatography with flame ionization detection (GC-FID). Spearman coefficients and Bland-Altman plots assessed correlation and agreement.
Results: The 30 participants were 29.7 ± 5.3 y, BMI 22.3 ± 2.7 kg/m², non-smokers. In fasting conditions, salivary FAs were dominated by palmitic (22.29%, IQR = 6.50%), oleic (21.63%, IQR = 9.54%), stearic (14.40%, IQR = 7.59%), and linoleic acid (8.52%, IQR = 6.42%). Only vaccenic acid showed a significant negative correlation with plasma (P = 0.005). At T1, positive correlations emerged only for total PUFAs between saliva and plasma (P = 0.028) and saliva and whole blood (P = 0.045). Bland-Altman analysis showed limited agreement across matrices, with small-to-moderate mean biases but wide limits of agreement (LoA).
Conclusion: Despite the small sample size and exploratory nature of the study, our findings support that salivary FAs may only partially reflect blood FA profiles, with substantial interindividual variability. Larger and more comprehensive studies are needed to confirm these preliminary results and clarify the conditions under which saliva could become a feasible alternative matrix.
{"title":"Validity of fatty acid profiling in saliva: A comparative analysis with blood-based matrices.","authors":"Martina Abodi, Anna Comotti, Stefano Turolo, Marie-Louise Syren, Gianluca Martino Tartaglia, Niccolò Cenzato, Camilla Bertoni, Silvia Bettocchi, Carlo Virginio Agostoni, Alessandra Mazzocchi, Gregorio Paolo Milani","doi":"10.1016/j.nut.2025.113086","DOIUrl":"https://doi.org/10.1016/j.nut.2025.113086","url":null,"abstract":"<p><strong>Objectives: </strong>Fatty acid (FA) profiling is nowadays performed from blood samples according to the research objective. Salivary FAs emerged as an innovative and non-invasive analysis providing information on dietary intake, pathological conditions, and metabolic status. However, evidence on the correlation of circulating with salivary FAs is, to our knowledge, unavailable. This pilot study aims to compare the FA profiles in saliva and blood in healthy adults, evaluating saliva as a potential surrogate matrix.</p><p><strong>Methods: </strong>Samples of saliva, plasma, and whole blood were collected from healthy subjects in fasting (T0) and postprandial (T1) conditions. FAs were analyzed using gas chromatography with flame ionization detection (GC-FID). Spearman coefficients and Bland-Altman plots assessed correlation and agreement.</p><p><strong>Results: </strong>The 30 participants were 29.7 ± 5.3 y, BMI 22.3 ± 2.7 kg/m², non-smokers. In fasting conditions, salivary FAs were dominated by palmitic (22.29%, IQR = 6.50%), oleic (21.63%, IQR = 9.54%), stearic (14.40%, IQR = 7.59%), and linoleic acid (8.52%, IQR = 6.42%). Only vaccenic acid showed a significant negative correlation with plasma (P = 0.005). At T1, positive correlations emerged only for total PUFAs between saliva and plasma (P = 0.028) and saliva and whole blood (P = 0.045). Bland-Altman analysis showed limited agreement across matrices, with small-to-moderate mean biases but wide limits of agreement (LoA).</p><p><strong>Conclusion: </strong>Despite the small sample size and exploratory nature of the study, our findings support that salivary FAs may only partially reflect blood FA profiles, with substantial interindividual variability. Larger and more comprehensive studies are needed to confirm these preliminary results and clarify the conditions under which saliva could become a feasible alternative matrix.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113086"},"PeriodicalIF":3.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}