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Third-trimester diet and prenatal depression in the MADRES cohort. MADRES队列中妊娠晚期饮食与产前抑郁的关系。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-11 DOI: 10.1016/j.nut.2026.113110
Caroline Ash, Luis E Maldonado, Tingyu Yang, Sandrah P Eckel, Claudia Toledo-Corral, Jill Johnston, Shohreh Farzan, Genevieve Dunton, Carrie Breton, Theresa Bastain

Background: Poor dietary intake has been linked to depression during pregnancy, but little research has examined this in Hispanic populations.

Objective: We examined third-trimester associations of study-derived dietary patterns with odds of prenatal depression and depressive symptoms in pregnant, low-income Hispanic women.

Methods: Participants (N = 587) were drawn from the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort in Los Angeles, CA. Diet was assessed using a 24-h recall tool. Women were assigned quartile rankings based on adherence to two previously derived dietary patterns: vegetables, oils, and fruit (VOF; healthier) and solid fats, refined grains, and cheese (SRC; less healthy). Depressive symptoms were defined using the Center for Epidemiological Studies-Depression Scale score, and a dichotomized depression outcome was defined as Center for Epidemiological Studies-Depression Scale scores ≥16.

Results: Eighteen percent of participants were classified as depressed at the third-trimester visit. Women with the greatest adherence to the healthier dietary pattern (VOF) had 59% lower odds of depression (OR = 0.41, 95% CI: 0.19, 0.86) relative to women with the lowest adherence to this dietary pattern, after adjustment for covariates. Additionally, women with moderately high (third quartile) adherence to the VOF dietary pattern had 16.9% lower depressive symptoms (95% CI: -30.5%, -0.8%) compared with women with the lowest VOF adherence. Women with the highest VOF adherence had similar, non-statistically significant lower depressive symptoms (Beta = -10.4%, 95% CI: -25.7%, 8.1%).

Conclusion: Our results indicate that there are important relationships between a healthy diet and lower depression in late pregnancy, and suggest that nutritional counseling and improved neighborhood access to healthy food may be important for maternal mental health.

背景:不良的饮食摄入与怀孕期间的抑郁症有关,但很少有研究在西班牙裔人群中对此进行调查。目的:我们研究了低收入西班牙裔孕妇妊娠晚期饮食模式与产前抑郁和抑郁症状的关联。方法:参与者(N = 587)来自加利福尼亚州洛杉矶的环境和社会压力源(MADRES)的产妇和发育风险队列。使用24小时回忆工具评估饮食。根据先前得出的两种饮食模式:蔬菜、油和水果(VOF;更健康)和固体脂肪、精制谷物和奶酪(SRC;不太健康),对女性进行了四分位数排名。使用流行病学研究中心抑郁量表评分来定义抑郁症状,以流行病学研究中心抑郁量表评分≥16分来定义二分类抑郁结局。结果:18%的参与者在妊娠晚期访问时被归类为抑郁症。在调整协变量后,最坚持健康饮食模式(VOF)的女性患抑郁症的几率比最不坚持健康饮食模式的女性低59% (OR = 0.41, 95% CI: 0.19, 0.86)。此外,中等高度(第三四分位数)坚持VOF饮食模式的女性与最低VOF饮食模式的女性相比,抑郁症状降低16.9% (95% CI: -30.5%, -0.8%)。VOF依从性最高的女性有相似的、无统计学意义的抑郁症状降低(Beta = -10.4%, 95% CI: -25.7%, 8.1%)。结论:我们的研究结果表明,健康饮食与妊娠后期抑郁发生率之间存在重要关系,并提示营养咨询和改善邻里健康食品的获取可能对孕产妇心理健康有重要作用。
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引用次数: 0
A single-center retrospective study investigating use of dietetic interventions and changes in nutritional intake and weight in children receiving proton beam therapy. 一项单中心回顾性研究调查了接受质子束治疗的儿童营养干预的使用和营养摄入和体重的变化。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-09 DOI: 10.1016/j.nut.2026.113105
Haleema Shabir, James Evans

Background: Proton beam therapy (PBT) is a novel treatment for children with certain cancers. It requires meticulous planning tailored to a child's body contour, shape, and size. Weight maintenance is essential throughout therapy to avoid unnecessary treatment replanning. Despite the specificity of PBT, gastrointestinal side effects can still occur and negatively impact children's nutritional intake.

Aim: Examine the use of dietetic interventions, weight change, and calorie intake of children during PBT.

Methods: A retrospective study at a single center was undertaken. Nutritional outcomes were examined at baseline, wk-1, wk-3, wk-6 of PBT, including changes in weight Z-score and calorie intake from oral and tube feeding routes. The impact of children's disease type on the need for tube feeding, weight change, and calorie intake was analyzed.

Results: One hundred and twelve children received PBT, of which 26% (29/112) did not require dietetic intervention and were excluded, but 74% (83/112) did and were included. Of these, 51% maintained their oral intake exclusively, 28% had a prophylactic gastrostomy (including 60%, 15/25 of those with head and neck cancer), 16% a prophylactic nasogastric tube (including 23%, 11/48 of those with neurological disease). From baseline to wk-6, 80% maintained their weight within 5% loss/gain. The mean weight Z-score significantly reduced from 0.22 to 0.10 (P = 0.038), as did oral calorie intake (P = 0.003). Calorie intake from tube feeding significantly increased (P = 0.006).

Conclusions: Nutritional support ensured that most children maintained a stable weight during PBT. A high prevalence of children required tube feeding via a gastrostomy or nasogastric tube as their oral intake declined.

背景:质子束治疗(PBT)是治疗儿童某些癌症的一种新方法。它需要根据孩子的身体轮廓、形状和大小进行细致的规划。在整个治疗过程中,体重维持是必不可少的,以避免不必要的治疗重新计划。尽管PBT具有特异性,但胃肠道副作用仍然可能发生,并对儿童的营养摄入产生负面影响。目的:检查PBT期间儿童饮食干预、体重变化和卡路里摄入的使用情况。方法:采用单中心回顾性研究。在PBT的基线、第1周、第3周、第6周检查营养结果,包括体重z评分的变化以及口服和管饲方式的卡路里摄入量。分析儿童疾病类型对管饲需求、体重变化和热量摄入的影响。结果:112名儿童接受了PBT,其中26%(29/112)不需要饮食干预而被排除,74%(83/112)需要饮食干预而被纳入。其中,51%的人完全维持口服摄入,28%的人进行了预防性胃造口术(包括60%,头颈癌患者的15/25),16%的人进行了预防性鼻胃管(包括23%,神经系统疾病患者的11/48)。从基线到第6周,80%的人将体重维持在5%的减重/增重范围内。平均体重z分数从0.22显著降低到0.10 (P = 0.038),口服卡路里摄入量也显著降低(P = 0.003)。管饲的热量摄入显著增加(P = 0.006)。结论:营养支持确保大多数儿童在PBT期间保持稳定的体重。由于儿童的口服摄入量下降,需要通过胃造口术或鼻胃管进行管饲的儿童比例很高。
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引用次数: 0
Influences of vegan status on protein intake, lean body mass, and strength in lightly active, young women: A cross-sectional study. 在轻度运动的年轻女性中,素食状态对蛋白质摄入、瘦体重和力量的影响:一项横断面研究。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-07 DOI: 10.1016/j.nut.2026.113102
Eric Bartholomae, Camila Nadalet, Carol S Johnston

Objectives: Plant-based diets are rising in popularity due to their health and environmental benefits. Vegan diets are a strict plant-based diet plan that excludes all animal foods, and reports suggest that a considerable portion of habitual vegans do not consume the daily recommended amount of protein.

Methods: This study utilized a cross-sectional study design to examine functional and structural markers of protein status (e.g., lean body mass and muscle strength) in healthy, lightly active women who habitually consumed a vegan (>1 y) or omnivore diet. Participants were matched by age, weight, and body mass index. Participants completed health and diet questionnaires and a physical activity assessment. Lean body mass was measured using dual-energy x-ray absorptiometry. Dynamometer testing was used to measure hand grip and leg strength. Inferential statistics and correlational analyses were used to examine differences between diet groups.

Results: Protein intakes and lean body mass were significantly lower for the vegan participants compared to those eating meat (-44% and -8%, respectively). Although hand grip strength was similar between diet groups, several indicators of leg strength were 14% to 15% lower in the vegan group compared to the omnivore group (P < 0.05). Correlates of strength varied by diet group: several strength markers were significantly correlated to lean mass in the vegan diet group, whereas strength and dietary protein were correlated in the omnivore diet group.

Conclusion: These data suggest that functional indicators of body protein status may be adversely impacted by long-term adherence to vegan diets in young adult women.

目的:植物性饮食由于其健康和环境效益而越来越受欢迎。纯素饮食是一种严格的以植物为基础的饮食计划,不包括所有动物食物,报告表明,相当一部分习惯性纯素者没有摄入每日推荐量的蛋白质。方法:本研究采用横断面研究设计,检查习惯吃纯素或杂食的健康、轻度运动女性的蛋白质状态的功能和结构标记(例如,瘦体重和肌肉力量)。参与者按年龄、体重和身体质量指数进行匹配。参与者完成了健康和饮食问卷以及身体活动评估。采用双能x线吸收仪测量瘦体重。使用测功机测试测量握力和腿部力量。采用推论统计和相关分析来检验饮食组之间的差异。结果:与吃肉的参与者相比,素食参与者的蛋白质摄入量和瘦体重显著降低(分别为-44%和-8%)。虽然饮食组之间的握力相似,但与杂食组相比,素食组的一些腿部力量指标要低14%至15% (P < 0.05)。力量的相关因素因饮食组而异:在纯素饮食组中,一些力量指标与瘦质量显著相关,而在杂食饮食组中,力量和膳食蛋白质相关。结论:这些数据表明,年轻成年女性长期坚持纯素饮食可能会对身体蛋白质状态的功能指标产生不利影响。
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引用次数: 0
Response to the Comment on: "Comparison of ChatGPT-3.5, ChatGPT-4.0 and DeepSeek in generating dietary plans for patients with chronic kidney disease: A focus on nutritional accuracy and dietary inflammation". 对“ChatGPT-3.5、ChatGPT-4.0和DeepSeek在为慢性肾病患者制定饮食计划中的比较:关注营养准确性和饮食炎症”评论的回复
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-07 DOI: 10.1016/j.nut.2025.113091
Xuemei Li, Qian You
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引用次数: 0
Polygenic risk score for lower limb skeletal muscle mass and its interaction with protein and vitamin D intake in older adults 老年人下肢骨骼肌质量的多基因风险评分及其与蛋白质和维生素D摄入量的相互作用
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-06 DOI: 10.1016/j.nut.2026.113100
Meiling Liu PhD , Sunmin Park PhD, RD

Objectives

Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS).

Methods

A genome-wide association study was conducted using UK Biobank data from 93,402 participants aged ≥65 y with bioelectrical impedance analysis results, including 14 076 with low-LSMI. Low-LSMI was defined as <5.7 kg/m² for men and <4.9 kg/m² for women based on EWGSOP2 (European Working Group on Sarcopenia in Older People 2) criteria. Secondary analyses included gene set enrichment analysis and tissue-specific expression profiling. A PRS was developed using generalized multifactor dimensionality reduction, and molecular docking analysis evaluated nutrient–protein binding.

Results

Results: Low-LSMI prevalence was higher in men than in women (18.5% vs. 11.8%), and was associated with elevated inflammatory markers (Hs-CRP: 3.43 vs. 2.73 mg/dL in men; P < 0.001), lower serum vitamin D (49.7 vs. 53.3 ng/mL in men; P < 0.001), and paradoxically lower metabolic syndrome prevalence. The strongest genetic association was rs77530409 in IL5RA (odds ratio [OR] = 1.97, P = 6.16 × 10⁻¹⁷). An optimal 4-single-nucleotide polymorphism (SNP) PRS model (FTO rs3751814, ADAMTSL3 rs4842838, CYP4F2 rs3093198, and DPP8 rs66993805) achieved an area under the curve of 0.852. Significant gene–lifestyle interactions were observed for high-risk individuals with low protein intake (OR = 1.35), low vitamin D (OR = 1.66), high alcohol consumption (OR = 1.54), or low physical activity (OR = 1.52). Molecular docking showed reduced binding affinity of vitamin D3 to the ADAMTSL3-mutated variant (661Leu; -8.7 kcal/mol) relative to the wild-type (Val661; -9.3 kcal/mol).

Conclusion

Conclusions: The 4-SNP PRS, combined with lifestyle assessment through gene–lifestyle interaction analysis, provides a tool for early risk stratification of muscle loss in older adults, with molecular evidence supporting personalized nutritional interventions.
目的:下肢骨骼肌质量是维持老年人身体功能所必需的,是肌肉减少症的早期指标。本研究旨在描述下肢骨骼肌指数(low-下肢骨骼肌指数)的多基因结构,确定潜在的生物学机制,并建立多基因风险评分(PRS)。方法利用英国生物银行93,402名年龄≥65岁的参与者的数据进行全基因组关联研究,并进行生物电阻抗分析结果,其中包括14076名低lsmi患者。根据EWGSOP2(欧洲老年人肌肉减少症工作组2)标准,低lsmi被定义为男性5.7 kg/m²,女性4.9 kg/m²。二级分析包括基因集富集分析和组织特异性表达谱。采用广义多因子降维方法建立了PRS,并通过分子对接分析对营养蛋白结合进行了评价。结果:低lsmi患病率男性高于女性(18.5% vs. 11.8%),并且与炎症标志物升高(男性Hs-CRP: 3.43 vs. 2.73 mg/dL; P < 0.001)、血清维生素D降低(男性49.7 vs. 53.3 ng/mL; P < 0.001)以及代谢综合征患病率降低相关。最强的遗传关联是rs77530409在IL5RA中(优势比[OR] = 1.97, P = 6.16 × 10⁻¹⁷)。最理想的4-单核苷酸多态性(SNP) PRS模型(FTO rs3751814、ADAMTSL3 rs4842838、CYP4F2 rs3093198、DPP8 rs66993805)曲线下面积为0.852。在低蛋白质摄入量(OR = 1.35)、低维生素D (OR = 1.66)、高酒精摄入量(OR = 1.54)或低体力活动(OR = 1.52)的高危人群中,观察到显著的基因-生活方式相互作用。分子对接显示,与野生型(Val661, -9.3 kcal/mol)相比,维生素D3与adamtsl3突变变体(661Leu, -8.7 kcal/mol)的结合亲和力降低。结论:4-SNP PRS结合基因-生活方式相互作用分析的生活方式评估,为老年人肌肉损失的早期风险分层提供了工具,并有分子证据支持个性化营养干预。
{"title":"Polygenic risk score for lower limb skeletal muscle mass and its interaction with protein and vitamin D intake in older adults","authors":"Meiling Liu PhD ,&nbsp;Sunmin Park PhD, RD","doi":"10.1016/j.nut.2026.113100","DOIUrl":"10.1016/j.nut.2026.113100","url":null,"abstract":"<div><h3>Objectives</h3><div>Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS).</div></div><div><h3>Methods</h3><div>A genome-wide association study was conducted using UK Biobank data from 93,402 participants aged ≥65 y with bioelectrical impedance analysis results, including 14 076 with low-LSMI. Low-LSMI was defined as &lt;5.7 kg/m² for men and &lt;4.9 kg/m² for women based on EWGSOP2 (European Working Group on Sarcopenia in Older People 2) criteria. Secondary analyses included gene set enrichment analysis and tissue-specific expression profiling. A PRS was developed using generalized multifactor dimensionality reduction, and molecular docking analysis evaluated nutrient–protein binding.</div></div><div><h3>Results</h3><div>Results: Low-LSMI prevalence was higher in men than in women (18.5% vs. 11.8%), and was associated with elevated inflammatory markers (Hs-CRP: 3.43 vs. 2.73 mg/dL in men; <em>P</em> &lt; 0.001), lower serum vitamin D (49.7 vs. 53.3 ng/mL in men; <em>P</em> &lt; 0.001), and paradoxically lower metabolic syndrome prevalence. The strongest genetic association was rs77530409 in <em>IL5RA</em> (odds ratio [OR] = 1.97, <em>P</em> = 6.16 × 10⁻¹⁷). An optimal 4-single-nucleotide polymorphism (SNP) PRS model (<em>FTO</em> rs3751814, <em>ADAMTSL3</em> rs4842838, <em>CYP4F2</em> rs3093198, and <em>DPP8</em> rs66993805) achieved an area under the curve of 0.852. Significant gene–lifestyle interactions were observed for high-risk individuals with low protein intake (OR = 1.35), low vitamin D (OR = 1.66), high alcohol consumption (OR = 1.54), or low physical activity (OR = 1.52). Molecular docking showed reduced binding affinity of vitamin D3 to the ADAMTSL3-mutated variant (661Leu; -8.7 kcal/mol) relative to the wild-type (Val661; -9.3 kcal/mol).</div></div><div><h3>Conclusion</h3><div>Conclusions: The 4-SNP PRS, combined with lifestyle assessment through gene–lifestyle interaction analysis, provides a tool for early risk stratification of muscle loss in older adults, with molecular evidence supporting personalized nutritional interventions.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113100"},"PeriodicalIF":3.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple anthropometric indicators compared with DXA-assessed visceral adiposity for screening brown adipose tissue activity in adult women. 简单人体测量指标与dxa评估的内脏脂肪筛选成年女性棕色脂肪组织活性的比较。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-05 DOI: 10.1016/j.nut.2026.113101
Isabela Solar, Maria Eduarda Martelli, Vinícius Ferreira Santos, Marina Maintinguer Norde, Lício Augusto Velloso, Bruno Geloneze, Ana Carolina Junqueira Vasques

Brown adipose tissue (BAT) activation increases energy expenditure and is associated with reduced body adiposity and improved cardiometabolic health. Therefore, we hypothesized that anthropometric parameters, particularly those reflecting central adiposity, could serve as indirect and straightforward markers for screening BAT activity. We evaluated the performance of anthropometric indicators, such as body mass index (BMI), waist circumference (WC), neck circumference (NC), sagittal abdominal diameter (SAD), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck-to-height ratio (NHtR), SAD-to-height ratio (SADHtR) and body roundness index (BRI), for screening of BAT activity (assessed by infrared thermography) in 122 adult women exposed to cold (for 2 h in an 18°C room), considering visceral adipose tissue (VAT) measured by dual-energy X-ray absorptiometry (DXA) as the harmful indicator of abdominal adiposity. Using multiple linear regression adjusted for age and physical activity level, and receiver operating characteristic (ROC) curves, we found that BMI, SAD, WC, and WHtR were the best indirect screeners of BAT activity, performing as well as VAT (p > 0.05 for all). These indicators may serve as practical proxies of BAT activity, potentially aiding in the development of strategies for metabolic disease intervention and prevention.

棕色脂肪组织(BAT)的激活增加了能量消耗,并与减少身体脂肪和改善心脏代谢健康有关。因此,我们假设人体测量参数,特别是反映中心性肥胖的参数,可以作为筛选BAT活性的间接和直接的标记。我们评估了人体测量指标的表现,如身体质量指数(BMI)、腰围(WC)、颈围(NC)、矢状腹径(SAD)、腰臀比(WHR)、腰高比(WHtR)、颈高比(NHtR)、腰高比(SADHtR)和身体圆度指数(BRI),以筛选122名暴露于寒冷(在18°C的房间中2小时)的成年女性的BAT活性(通过红外热成像评估)。考虑双能x线吸收仪(DXA)测量的内脏脂肪组织(VAT)作为腹部肥胖的有害指标。采用调整了年龄、体力活动水平和受试者工作特征(ROC)曲线的多元线性回归,我们发现BMI、SAD、WC和WHtR是BAT活性的最佳间接筛查指标,VAT也是如此(p < 0.05)。这些指标可以作为BAT活性的实际替代指标,可能有助于制定代谢性疾病干预和预防策略。
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引用次数: 0
Changes in raw bioelectrical impedance parameters as markers of body composition in youth: A prospective cohort investigation 原始生物电阻抗参数的变化作为青少年身体组成的标记:一项前瞻性队列调查
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-02 DOI: 10.1016/j.nut.2025.113089
Gil B Rosa M.D. , Ruben Francisco Ph.D. , Analiza M Silva Ph.D. , Henry C Lukaski Ph.D. , Luís B Sardinha Ph.D.

Objectives

Despite cross-sectional evidence supporting raw bioelectrical impedance analysis (BIA) parameters as informative markers of body composition in youth, their role from a longitudinal perspective remains unclear. We examined how 1-y changes in phase angle (PhA) and other raw BIA parameters were associated with changes in body components at multiple levels in children and adolescents.

Methods

In a 1-y prospective cohort investigation, including 562 healthy and on-time matured youth (51.6% females), we assessed raw BIA parameters with a phase-sensitive 50 kHz BIA device and examined body composition through dual-energy X-ray absorptiometry and related models. The association between changes in raw BIA parameters and changes in body composition by sex and peak height velocity (PHV) stage was analyzed using multiple linear regression.

Results

PhA was positively associated with changes in fat-related components, fat-free mass, extracellular water, fluids and solids, osseous minerals, and muscle tissue in females (β = 0.088–0.150; P ≤ 0.05) and with alterations in most body components in males (β = 0.098–0.300; P ≤ 0.05). Similar trends to those of males were observed in both sexes during post-PHV (females: β = 0.149–0.297; males: β = 0.185–0.352; P ≤ 0.05). Other series and parallel BIA parameters exhibited even higher explanatory power of body composition than PhA, with the magnitude of the associations depending on each raw BIA parameter, sex, and PHV stage (females: β =|0.099|–|0.429|; males: β = |0.106|–|0.706|; P ≤ 0.05). Among all raw BIA parameters, the highest associations were observed in resistance adjusted to stature (RI) (total sample and pre-PHV), parallel capacitive reactance adjusted to stature (XcpI), and capacitance (Cap) (both post-PHV).

Conclusion

PhA emerged as a modest marker of body composition dynamics in youth, particularly in males and during adolescence (post-PHV), whereas other raw BIA parameters, particularly RI, XcpI, and Cap, showed even greater promise in both sexes and across development stages.
尽管横断面证据支持原始生物电阻抗分析(BIA)参数作为青少年身体成分的信息标记,但从纵向角度来看,它们的作用仍不清楚。我们研究了1-y相位角(PhA)和其他原始BIA参数的变化如何与儿童和青少年在多个水平上的身体成分变化相关。方法在一项为期1年的前瞻性队列研究中,我们使用相敏50 kHz BIA装置评估了原始BIA参数,并通过双能x线吸收仪和相关模型检测了身体成分。采用多元线性回归分析原始BIA参数变化与体成分性别变化和峰高速度(PHV)阶段的关系。结果spha与女性脂肪相关成分、无脂质量、细胞外水、液体和固体、骨矿物质和肌肉组织的变化呈正相关(β = 0.088 ~ 0.150, P≤0.05),与男性大部分身体成分的变化呈正相关(β = 0.098 ~ 0.300, P≤0.05)。两性在phv后的变化趋势与男性相似(女性β = 0.149 ~ 0.297,男性β = 0.185 ~ 0.352, P≤0.05)。其他串联和并联BIA参数对身体组成的解释能力甚至高于PhA,其相关性程度取决于每个原始BIA参数、性别和PHV阶段(女性:β =|0.099| - |0.429|;男性:β =| 0.106| - |0.706|, P≤0.05)。在所有原始BIA参数中,根据身高调整的电阻(RI)(总样品和phv前)、根据身高调整的并联容抗(XcpI)和电容(Cap)(均为phv后)的相关性最高。pha在青少年时期,尤其是男性和青春期(phv后)作为身体成分动态的适度标志出现,而其他原始BIA参数,特别是RI、XcpI和Cap,在两性和不同发育阶段都显示出更大的前景。
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引用次数: 0
Association between spicy food consumption and inflammatory bowel disease: A case-control study from Saudi Arabia 食用辛辣食物与炎症性肠病之间的关系:一项来自沙特阿拉伯的病例对照研究
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-01 DOI: 10.1016/j.nut.2025.113087
Anas Almofarreh M.D., M.P.H. , Haytham A. Sheerah M.D., Ph.D. , Ahmed Arafa M.D., Ph.D. , Tareq Moh’d M.D. , Rayan A. Tayyib M.D. , Ahad N. Yamani M.D., M.P.H. , Aidrous M. Ali M.D., M.P.H.

Background

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic gastrointestinal disorder with increasing global prevalence. Although dietary factors are increasingly implicated in IBD pathogenesis, the role of spicy food remains unclear, especially in Arab populations where such foods are commonly consumed. This study aimed to examine the association between spicy food consumption and the risk of UC and CD in an Arab population.

Methods

We conducted a case-control study at a private clinic in Saudi Arabia, involving 157 patients with UC, 226 with CD, and 390 controls. IBD was diagnosed using laboratory tests, endoscopy with biopsies, and imaging when indicated. Spicy food was defined as dishes made with chili peppers or hot sauces and was assessed using a self-administered questionnaire. Multivariable logistic regression was used to evaluate the association between spicy food intake and IBD risk, and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.

Results

Daily consumption of spicy food was significantly associated with higher odds of CD (OR = 1.61; 95% CI: 1.11, 2.33), but not UC (OR = 1.03; 95% CI: 0.67, 1.60). No significant associations were observed between spicy food and IBD extent or severity.

Conclusions

In this Arab population, daily spicy food intake was positively associated with CD risk, while no association was identified for UC. Future prospective cohort studies with detailed information about spicy food types and IBD severity scores are needed to confirm our findings.
背景:炎症性肠病(IBD),包括溃疡性结肠炎(UC)和克罗恩病(CD),是一种慢性胃肠道疾病,全球患病率越来越高。尽管饮食因素越来越多地与IBD发病机制有关,但辛辣食物的作用仍不清楚,特别是在经常食用辛辣食物的阿拉伯人群中。本研究旨在研究阿拉伯人群中食用辛辣食物与UC和CD风险之间的关系。方法我们在沙特阿拉伯的一家私人诊所进行了一项病例对照研究,涉及157例UC患者,226例CD患者和390例对照组。IBD的诊断方法包括实验室检查、内窥镜活检和必要时的影像学检查。辛辣食物被定义为用辣椒或辣酱制作的菜肴,并通过自我管理的问卷进行评估。采用多变量logistic回归评估辛辣食物摄入与IBD风险之间的关系,并计算校正优势比(ORs)和95%置信区间(ci)。结果:每天食用辛辣食物与较高的CD发生率显著相关(OR = 1.61; 95% CI: 1.11, 2.33),但与UC无关(OR = 1.03; 95% CI: 0.67, 1.60)。没有观察到辛辣食物与IBD程度或严重程度之间的显著关联。结论:在这些阿拉伯人群中,每日摄入辛辣食物与乳糜泻风险呈正相关,而未发现与UC风险相关。未来的前瞻性队列研究需要提供有关辛辣食物类型和IBD严重程度评分的详细信息来证实我们的发现。
{"title":"Association between spicy food consumption and inflammatory bowel disease: A case-control study from Saudi Arabia","authors":"Anas Almofarreh M.D., M.P.H. ,&nbsp;Haytham A. Sheerah M.D., Ph.D. ,&nbsp;Ahmed Arafa M.D., Ph.D. ,&nbsp;Tareq Moh’d M.D. ,&nbsp;Rayan A. Tayyib M.D. ,&nbsp;Ahad N. Yamani M.D., M.P.H. ,&nbsp;Aidrous M. Ali M.D., M.P.H.","doi":"10.1016/j.nut.2025.113087","DOIUrl":"10.1016/j.nut.2025.113087","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic gastrointestinal disorder with increasing global prevalence. Although dietary factors are increasingly implicated in IBD pathogenesis, the role of spicy food remains unclear, especially in Arab populations where such foods are commonly consumed. This study aimed to examine the association between spicy food consumption and the risk of UC and CD in an Arab population.</div></div><div><h3>Methods</h3><div>We conducted a case-control study at a private clinic in Saudi Arabia, involving 157 patients with UC, 226 with CD, and 390 controls. IBD was diagnosed using laboratory tests, endoscopy with biopsies, and imaging when indicated. Spicy food was defined as dishes made with chili peppers or hot sauces and was assessed using a self-administered questionnaire. Multivariable logistic regression was used to evaluate the association between spicy food intake and IBD risk, and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</div></div><div><h3>Results</h3><div>Daily consumption of spicy food was significantly associated with higher odds of CD (OR = 1.61; 95% CI: 1.11, 2.33), but not UC (OR = 1.03; 95% CI: 0.67, 1.60). No significant associations were observed between spicy food and IBD extent or severity.</div></div><div><h3>Conclusions</h3><div>In this Arab population, daily spicy food intake was positively associated with CD risk, while no association was identified for UC. Future prospective cohort studies with detailed information about spicy food types and IBD severity scores are needed to confirm our findings.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113087"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing food and nutrient security in Taiwan: Integrating sustainability and the planetary health diet. 评估台湾的粮食和营养安全:整合可持续性和全球健康饮食。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-12-31 DOI: 10.1016/j.nut.2025.113085
Dang Hien Ngan Nguyen, Chiao-Ming Chen, Shih-Ping Lin, Hong Nhung Lam, Chien-Tien Su, Kang Ernest Liu, Shu-Chen Lee, Sing-Chung Li

Objectives: Food and nutrient security are critical for population health and environmental sustainability. This study aimed to assess Taiwan's food and nutrient security and its alignment with the planetary health diet (PHD), integrating CO2 impact analysis.

Methods: This study introduces the Food Security Index (FSI) and Nutrient Security Index (NSI) to assess Taiwan's food and nutrient security. It also examines adherence to the PHD and uses life cycle assessment to evaluate CO₂ emissions across regions/countries, offering a comprehensive view of environmental impacts. From 2017 to 2020, the Nutrition and Health Survey in Taiwan estimated the prevalence of undernourishment (PoU) for 12 120 participants using FAO methods. Additionally, the Food Insecurity Experience Scale (FIES) was calculated for 2879 participants in 2022-23 with FAO's RM.weights package. The FSI and NSI were derived from supply-to-needs (S-Nr) and intake-to-needs (I-Nr) ratios using NAHSIT and the food balance sheet (FBS). Moreover, PHD score (PHDS) was applied to assess PHD adherence and compare CO₂ emissions across 12 regions/countries using FBS.

Results: Taiwan with PoU below 2.5% (2017-20), FIES 1.1% (2022-23). FBS showed S-Nr 0.84 for vegetables, 0.77 for fruits, and 0.47 for dairy. I-Nr for calcium was 0.56, while NAHSIT S-Nr was 0.97 for cereals/roots, 0.36 for dairy, and 0.71 for vegetables/fruits, I-Nr 0.58 for fiber, 0.56 for calcium, and 0.49 for vitamin D. Taiwan achieved the highest PHDS (48.55%), while Brazil had the lowest (31.06%). A moderate negative correlation (r = -0.413) was found between PHDS and food-related CO₂ emissions.

Conclusion: Despite high food security, targeted policies are needed to address nutrient imbalances and promote sustainable diets.

目标:粮食和营养安全对人口健康和环境可持续性至关重要。本研究旨在结合二氧化碳影响分析,评估台湾的食物和营养安全及其与全球健康饮食(PHD)的一致性。方法:本研究引入食品安全指数(FSI)与营养安全指数(NSI)来评估台湾的食品与营养安全。它还检查了对博士学位的遵守情况,并使用生命周期评估来评估各地区/国家的二氧化碳排放量,提供了对环境影响的全面看法。从2017年到2020年,台湾的营养与健康调查使用粮农组织的方法估计了12120名参与者的营养不良发生率。此外,粮食不安全体验量表(FIES)是由粮农组织的RM在2022-23年为2879名参与者计算的。重量包。FSI和NSI是利用NAHSIT和粮食资产负债表(FBS)从供应对需求(S-Nr)和摄入对需求(I-Nr)比率得出的。此外,博士分数(PHDS)被用于评估博士学位的遵守情况,并使用FBS比较了12个地区/国家的二氧化碳排放量。结果:台湾PoU低于2.5%(2017-20年),FIES低于1.1%(2022-23年)。FBS结果显示,蔬菜、水果和乳制品的S-Nr分别为0.84、0.77和0.47。钙的I-Nr为0.56,而谷物/根类的S-Nr为0.97,乳制品为0.36,蔬菜/水果为0.71,纤维的I-Nr为0.58,钙的I-Nr为0.56,维生素d的I-Nr为0.49。台湾的博士学位最高(48.55%),巴西最低(31.06%)。博士学位与食物相关的二氧化碳排放量呈中等负相关(r = -0.413)。结论:尽管粮食安全水平很高,但需要有针对性的政策来解决营养失衡问题并促进可持续饮食。
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引用次数: 0
Validity of fatty acid profiling in saliva: A comparative analysis with blood-based matrices. 唾液中脂肪酸谱分析的有效性:与血液基质的比较分析。
IF 3 3区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2025-12-30 DOI: 10.1016/j.nut.2025.113086
Martina Abodi, Anna Comotti, Stefano Turolo, Marie-Louise Syren, Gianluca Martino Tartaglia, Niccolò Cenzato, Camilla Bertoni, Silvia Bettocchi, Carlo Virginio Agostoni, Alessandra Mazzocchi, Gregorio Paolo Milani

Objectives: Fatty acid (FA) profiling is nowadays performed from blood samples according to the research objective. Salivary FAs emerged as an innovative and non-invasive analysis providing information on dietary intake, pathological conditions, and metabolic status. However, evidence on the correlation of circulating with salivary FAs is, to our knowledge, unavailable. This pilot study aims to compare the FA profiles in saliva and blood in healthy adults, evaluating saliva as a potential surrogate matrix.

Methods: Samples of saliva, plasma, and whole blood were collected from healthy subjects in fasting (T0) and postprandial (T1) conditions. FAs were analyzed using gas chromatography with flame ionization detection (GC-FID). Spearman coefficients and Bland-Altman plots assessed correlation and agreement.

Results: The 30 participants were 29.7 ± 5.3 y, BMI 22.3 ± 2.7 kg/m², non-smokers. In fasting conditions, salivary FAs were dominated by palmitic (22.29%, IQR = 6.50%), oleic (21.63%, IQR = 9.54%), stearic (14.40%, IQR = 7.59%), and linoleic acid (8.52%, IQR = 6.42%). Only vaccenic acid showed a significant negative correlation with plasma (P = 0.005). At T1, positive correlations emerged only for total PUFAs between saliva and plasma (P = 0.028) and saliva and whole blood (P = 0.045). Bland-Altman analysis showed limited agreement across matrices, with small-to-moderate mean biases but wide limits of agreement (LoA).

Conclusion: Despite the small sample size and exploratory nature of the study, our findings support that salivary FAs may only partially reflect blood FA profiles, with substantial interindividual variability. Larger and more comprehensive studies are needed to confirm these preliminary results and clarify the conditions under which saliva could become a feasible alternative matrix.

目的:根据研究目的,目前从血液样本中进行脂肪酸(FA)分析。唾液FAs是一种创新的、无创的分析方法,可以提供饮食摄入、病理状况和代谢状态的信息。然而,据我们所知,循环与唾液FAs之间的相关性尚无证据。本初步研究旨在比较健康成人唾液和血液中的FA谱,评估唾液作为潜在的替代基质。方法:采集健康受试者空腹(T0)和餐后(T1)的唾液、血浆和全血样本。用气相色谱-火焰离子化检测器(GC-FID)分析FAs。Spearman系数和Bland-Altman图评估相关性和一致性。结果:30例患者体重29.7±5.3岁,体重指数22.3±2.7 kg/m²,不吸烟。在空腹条件下,唾液FAs主要为棕榈酸(22.29%,IQR = 6.50%)、油酸(21.63%,IQR = 9.54%)、硬脂酸(14.40%,IQR = 7.59%)和亚油酸(8.52%,IQR = 6.42%)。只有异丙酸与血浆呈显著负相关(P = 0.005)。在T1时,只有唾液和血浆(P = 0.028)以及唾液和全血(P = 0.045)之间的PUFAs总量呈正相关。Bland-Altman分析显示,矩阵之间的一致性有限,具有小到中等的平均偏差,但一致性的限制范围很广(LoA)。结论:尽管本研究样本量小且具有探索性,但我们的研究结果支持唾液FA可能仅部分反映血液FA谱,且存在显著的个体间差异。需要更大规模、更全面的研究来证实这些初步结果,并阐明唾液成为可行替代基质的条件。
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引用次数: 0
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Nutrition
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