Construction of an intelligent pH-sensitive hydrogel drug delivery system and its application in gastric ulcer treatment

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Journal of the Indian Chemical Society Pub Date : 2024-09-19 DOI:10.1016/j.jics.2024.101390

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Abstract

The occurrence of gastric ulcer is mainly due to the damage of gastric mucosa which leads to inward flow of gastric acid to corrode the gastric cavity, thus producing gastric fever, vomiting, loss of appetite and other adverse reactions. Prevention and treatment of such injuries are crucial. In this study, a simple and non-toxic composite hydrogel (PLGA/CMCS) was prepared through Schiff base reaction between poly(lactic-co-glycolic acid) (PLGA) and carboxymethyl cellulose (CMCS). Subsequently, compound 1 was loaded onto it to construct PLGA/CMCS@1. A series of structural characterization and performance experiments were conducted on these novel hydrogel polymers. Furthermore, we detected the gene expression level of Fas/FasL apoptotic pathway after treating the cells with different concentrations of PLGA/CMCS@1 through an ethanol-induced damaged gastric mucosal epithelial cell model. The results showed that the system was able to significantly regulate the expression of genes related to the apoptotic pathway. The system can regulate the Fas/FasL apoptosis pathway to treat gastric ulcer.

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智能 pH 值敏感水凝胶给药系统的构建及其在胃溃疡治疗中的应用

胃溃疡的发生主要是由于胃黏膜损伤导致胃酸内流腐蚀胃腔，从而产生胃热、呕吐、食欲不振等不良反应。预防和治疗此类损伤至关重要。本研究通过聚乳酸-共聚乙醇酸（PLGA）和羧甲基纤维素（CMCS）之间的席夫碱反应制备了一种简单无毒的复合水凝胶（PLGA/CMCS）。我们对这些新型水凝胶聚合物进行了一系列结构表征和性能实验。此外，我们还通过乙醇诱导的受损胃黏膜上皮细胞模型，检测了不同浓度的 PLGA/CMCS@1 处理细胞后 Fas/FasL 细胞凋亡通路的基因表达水平。结果表明，该系统能显著调控凋亡通路相关基因的表达。该系统能调节 Fas/FasL 细胞凋亡途径，从而治疗胃溃疡。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.