{"title":"Functional analysis of Hikeshi reveals physiological significance of nuclear Hsp70","authors":"Naoko Imamoto","doi":"10.1016/j.ceb.2024.102426","DOIUrl":null,"url":null,"abstract":"<div><div>Nucleocytoplasmic transport is a basic cellular reaction that plays an important role in regulating cell physiology in eukaryotic cells. Here we show that the identification of one nucleocytoplasmic transport pathway led to the notification of intracellular reaction that has not been acknowledged. Hikeshi was originally identified as a nuclear import carrier of heat stress–induced nuclear import of molecular chaperone Hsp70. We now know that Hikeshi mediates nuclear import of Hsp70 at a variety of different cellular conditions, such as at normal conditions, at proteotoxic conditions, during differentiation, and probably more. Recent studies gradually revealed the physiological significances of Hikeshi-mediated nuclear import of Hsp70.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"91 ","pages":"Article 102426"},"PeriodicalIF":6.0000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0955067424001054","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Nucleocytoplasmic transport is a basic cellular reaction that plays an important role in regulating cell physiology in eukaryotic cells. Here we show that the identification of one nucleocytoplasmic transport pathway led to the notification of intracellular reaction that has not been acknowledged. Hikeshi was originally identified as a nuclear import carrier of heat stress–induced nuclear import of molecular chaperone Hsp70. We now know that Hikeshi mediates nuclear import of Hsp70 at a variety of different cellular conditions, such as at normal conditions, at proteotoxic conditions, during differentiation, and probably more. Recent studies gradually revealed the physiological significances of Hikeshi-mediated nuclear import of Hsp70.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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