Study on the interventional effects of Chlamydomonas reinhardtii peptides on chronic unpredictable mild stress-induced depressive-like model mice through metabolomics and microbiota

IF 4.6 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2024-09-23 DOI:10.1016/j.algal.2024.103715
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Abstract

Depression is a progressive neurodegenerative disease characterized by high prevalence, high suicide rate and high recurrence rate. In this study, the protein from Chlamydomonas reinhardtii was extracted and neutral protease hydrolysate (NPH) was obtained. Its in vitro MAO-A (Monoamine oxidase A) inhibitory activity and in vivo anti-depressive effects in chronic unpredictable mild stress (CUMS) model mice were investigated. The results demonstrated that NPH can improve depressive behaviour in CUMS model mice by elevating neurotransmitter levels and alleviating hippocampal tissue structure damage. The metabolomic analysis of brain and serum samples showed that their common metabolic pathways associated with anti-depressive effects are mainly alanine, aspartate, and glutamate metabolism, glycerophospholipid metabolism, tryptophan metabolism, and caffeine metabolism. Then, the gut microbiota analysis of feces indicated that 8 species with significant changes were associated with anti-depressive effects. Finally, 5 pairs of highly correlated metabolite-bacterium pairs were identified to modulate depressive behaviours. Taken together, the present data suggests that Chlamydomonas reinhardtii-derived hydrolysate could be used for development of functional foods with potential to improve depression.

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通过代谢组学和微生物群研究衣藻多肽对慢性不可预测轻度应激诱导的抑郁样模型小鼠的干预作用
抑郁症是一种进行性神经退行性疾病,具有高发病率、高自杀率和高复发率的特点。本研究从衣藻中提取蛋白质,得到中性蛋白酶水解物(NPH)。研究了NPH的体外MAO-A(单胺氧化酶A)抑制活性和在慢性不可预知轻度应激(CUMS)模型小鼠体内的抗抑郁作用。结果表明,NPH能通过提高神经递质水平和减轻海马组织结构损伤来改善CUMS模型小鼠的抑郁行为。脑样本和血清样本的代谢组学分析表明,它们与抗抑郁作用相关的常见代谢途径主要是丙氨酸、天门冬氨酸和谷氨酸代谢、甘油磷脂代谢、色氨酸代谢和咖啡因代谢。然后,粪便中的肠道微生物群分析表明,有 8 个物种的显著变化与抗抑郁作用有关。最后,还发现了 5 对高度相关的代谢物-细菌配对,可调节抑郁行为。综上所述,本研究的数据表明,衣藻衍生的水解物可用于开发具有改善抑郁潜能的功能性食品。
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来源期刊
Algal Research-Biomass Biofuels and Bioproducts
Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
9.40
自引率
7.80%
发文量
332
期刊介绍: Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
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