Topical formulations contained an extract from marine alga Cladophora glomerata

IF 4.6 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2024-09-21 DOI:10.1016/j.algal.2024.103717
{"title":"Topical formulations contained an extract from marine alga Cladophora glomerata","authors":"","doi":"10.1016/j.algal.2024.103717","DOIUrl":null,"url":null,"abstract":"<div><div>The <em>Cladophora glomerata</em> is a green alga abundant in fresh and seawater. The extraction of <em>C. glomerata</em> using glycol-based solvents, including butylene glycol (BG), polyethylene glycol 400 (PEG 400), and propylene glycol (PG), as the green solvents to obtain antioxidants and nutrients that can be further used in health care and pharmaceutical applications. The extraction of <em>C. glomerata</em> with glycol-base solvents using the microwave-assisted extraction (MAE) method was optimized. The liquid extraction using 60 % volume by volume of polyethylene glycol yielded the highest total phenolic content (4.00 ± 0.08 mg gallic acid equivalence per g dry weight) and antioxidant activity (IC<sub>50</sub> 0.14 ± 0.02 mg/mL). The algal extract was stable at pH 6 to 8 and a temperature lower than 25 °C. After incorporating the algal extract in topical formulations including serum and emulgel, we found that the preparations were stable and retained the extract's antioxidant activity. In addition, all algal extracts, extract-loaded serum, and emulgel did not show cytotoxicity effects in normal adult human dermal fibroblasts.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Algal Research-Biomass Biofuels and Bioproducts","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211926424003291","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The Cladophora glomerata is a green alga abundant in fresh and seawater. The extraction of C. glomerata using glycol-based solvents, including butylene glycol (BG), polyethylene glycol 400 (PEG 400), and propylene glycol (PG), as the green solvents to obtain antioxidants and nutrients that can be further used in health care and pharmaceutical applications. The extraction of C. glomerata with glycol-base solvents using the microwave-assisted extraction (MAE) method was optimized. The liquid extraction using 60 % volume by volume of polyethylene glycol yielded the highest total phenolic content (4.00 ± 0.08 mg gallic acid equivalence per g dry weight) and antioxidant activity (IC50 0.14 ± 0.02 mg/mL). The algal extract was stable at pH 6 to 8 and a temperature lower than 25 °C. After incorporating the algal extract in topical formulations including serum and emulgel, we found that the preparations were stable and retained the extract's antioxidant activity. In addition, all algal extracts, extract-loaded serum, and emulgel did not show cytotoxicity effects in normal adult human dermal fibroblasts.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
外用制剂含有海洋藻类 Cladophora glomerata 的提取物
团扇藻是一种绿色藻类,在淡水和海水中含量丰富。使用乙二醇基溶剂(包括丁二醇(BG)、聚乙二醇 400(PEG 400)和丙二醇(PG))作为绿色溶剂萃取团扇藻,可获得抗氧化剂和营养物质,并可进一步应用于保健和制药领域。利用微波辅助萃取(MAE)法,对乙二醇基溶剂萃取草苁蓉进行了优化。使用体积分数为 60% 的聚乙二醇进行液体萃取时,总酚含量(每克干重 4.00 ± 0.08 毫克没食子酸当量)和抗氧化活性(IC50 0.14 ± 0.02 毫克/毫升)最高。海藻提取物在 pH 值为 6 至 8 和温度低于 25 °C 的条件下稳定。将海藻提取物加入血清和凝胶等外用制剂后,我们发现这些制剂非常稳定,并保留了提取物的抗氧化活性。此外,所有海藻萃取物、萃取物负载的血清和凝胶在正常成人真皮成纤维细胞中均未显示出细胞毒性效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Algal Research-Biomass Biofuels and Bioproducts
Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
9.40
自引率
7.80%
发文量
332
期刊介绍: Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
期刊最新文献
Experimental evaluation of Scenedesmus javanensis, Halochlorella rubescens, and Chlorolobion braunii for lipid-rich biomass production and phycoremediation of dairy wastewater In vitro evaluation of functional properties of extracts of Fucus vesiculosus obtained with different conventional solvents Impact of low-dose X-ray radiation on the lipidome of Chlorella vulgaris Macroalgae and microalga blend in dogs' food: Effects on palatability, digestibility, and fecal metabolites and microbiota Scenedesmus subspicatus potential for pharmacological compounds removal from aqueous media
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1