{"title":"Topical formulations contained an extract from marine alga Cladophora glomerata","authors":"","doi":"10.1016/j.algal.2024.103717","DOIUrl":null,"url":null,"abstract":"<div><div>The <em>Cladophora glomerata</em> is a green alga abundant in fresh and seawater. The extraction of <em>C. glomerata</em> using glycol-based solvents, including butylene glycol (BG), polyethylene glycol 400 (PEG 400), and propylene glycol (PG), as the green solvents to obtain antioxidants and nutrients that can be further used in health care and pharmaceutical applications. The extraction of <em>C. glomerata</em> with glycol-base solvents using the microwave-assisted extraction (MAE) method was optimized. The liquid extraction using 60 % volume by volume of polyethylene glycol yielded the highest total phenolic content (4.00 ± 0.08 mg gallic acid equivalence per g dry weight) and antioxidant activity (IC<sub>50</sub> 0.14 ± 0.02 mg/mL). The algal extract was stable at pH 6 to 8 and a temperature lower than 25 °C. After incorporating the algal extract in topical formulations including serum and emulgel, we found that the preparations were stable and retained the extract's antioxidant activity. In addition, all algal extracts, extract-loaded serum, and emulgel did not show cytotoxicity effects in normal adult human dermal fibroblasts.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Algal Research-Biomass Biofuels and Bioproducts","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211926424003291","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The Cladophora glomerata is a green alga abundant in fresh and seawater. The extraction of C. glomerata using glycol-based solvents, including butylene glycol (BG), polyethylene glycol 400 (PEG 400), and propylene glycol (PG), as the green solvents to obtain antioxidants and nutrients that can be further used in health care and pharmaceutical applications. The extraction of C. glomerata with glycol-base solvents using the microwave-assisted extraction (MAE) method was optimized. The liquid extraction using 60 % volume by volume of polyethylene glycol yielded the highest total phenolic content (4.00 ± 0.08 mg gallic acid equivalence per g dry weight) and antioxidant activity (IC50 0.14 ± 0.02 mg/mL). The algal extract was stable at pH 6 to 8 and a temperature lower than 25 °C. After incorporating the algal extract in topical formulations including serum and emulgel, we found that the preparations were stable and retained the extract's antioxidant activity. In addition, all algal extracts, extract-loaded serum, and emulgel did not show cytotoxicity effects in normal adult human dermal fibroblasts.
期刊介绍:
Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment