The dietary supplementation of Sargassum fusiforme can effectively alleviate high-fat diet induced metabolic abnormalities

IF 4.6 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Algal Research-Biomass Biofuels and Bioproducts Pub Date : 2024-09-22 DOI:10.1016/j.algal.2024.103722
{"title":"The dietary supplementation of Sargassum fusiforme can effectively alleviate high-fat diet induced metabolic abnormalities","authors":"","doi":"10.1016/j.algal.2024.103722","DOIUrl":null,"url":null,"abstract":"<div><div><em>Sargassum fusiforme</em>, a brown seaweed widely consumed as a culinary delicacy and medicinal herb in East Asian countries, contains multiple bioactive compounds with anti-inflammatory, antioxidant, and anti-obesity properties. This suggests that its dietary consumption could help mitigate metabolic diseases induced by high-fat diet (HFD). To test this hypothesis, we initially analyzed the nutritional components of the macroalga, and evaluated its acute oral toxicity and long-term safety. Subsequently, we explored the impacts of its dietary intake on HFD-fed mice. Additionally, 16S rRNA sequencing was employed to further elucidate the mechanism underlying the protective effects of this macroalga against HFD-induced metabolic abnormalities. Our results revealled that <em>S. fusiforme</em> has a desirable nutrient profile, characterized by rich carbohydrates, polyunsaturated fatty acids, and carotenoids, and is also highly safe for consumption. Its dietary intake remarkably alleviated HFD-induced metabolic disorders. Analysis of gut microbiota showed that HFD consumption increased the relative abundance of Firmicutes and decreased Bacteroidetes. This trend was further exacerbated by <em>S. fusiforme</em> supplementation, resulting in a higher Firmicutes/Bacteroidetes ratio compared to both the control and HFD groups. At the genus level, <em>Muribaculum</em>, <em>Lactobacillus</em>, <em>Clostridia_UCG_014</em>, <em>Clostridium</em>_sp, <em>Acetatifactor</em>, <em>Eubacterium_coprostanoligenes</em>, and <em>IS_44</em> (from family Nitrosomonadaceae) were significantly enriched in the mice supplemented with <em>S. fusiforme</em>. These findings support the potential use of <em>S. fusiforme</em> as a functional food to counteract HFD-induced metabolic dysbiosis.</div></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Algal Research-Biomass Biofuels and Bioproducts","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211926424003345","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Sargassum fusiforme, a brown seaweed widely consumed as a culinary delicacy and medicinal herb in East Asian countries, contains multiple bioactive compounds with anti-inflammatory, antioxidant, and anti-obesity properties. This suggests that its dietary consumption could help mitigate metabolic diseases induced by high-fat diet (HFD). To test this hypothesis, we initially analyzed the nutritional components of the macroalga, and evaluated its acute oral toxicity and long-term safety. Subsequently, we explored the impacts of its dietary intake on HFD-fed mice. Additionally, 16S rRNA sequencing was employed to further elucidate the mechanism underlying the protective effects of this macroalga against HFD-induced metabolic abnormalities. Our results revealled that S. fusiforme has a desirable nutrient profile, characterized by rich carbohydrates, polyunsaturated fatty acids, and carotenoids, and is also highly safe for consumption. Its dietary intake remarkably alleviated HFD-induced metabolic disorders. Analysis of gut microbiota showed that HFD consumption increased the relative abundance of Firmicutes and decreased Bacteroidetes. This trend was further exacerbated by S. fusiforme supplementation, resulting in a higher Firmicutes/Bacteroidetes ratio compared to both the control and HFD groups. At the genus level, Muribaculum, Lactobacillus, Clostridia_UCG_014, Clostridium_sp, Acetatifactor, Eubacterium_coprostanoligenes, and IS_44 (from family Nitrosomonadaceae) were significantly enriched in the mice supplemented with S. fusiforme. These findings support the potential use of S. fusiforme as a functional food to counteract HFD-induced metabolic dysbiosis.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
膳食补充马尾藻能有效缓解高脂饮食引起的代谢异常
马尾藻(Sargassum fusiforme)是一种褐色海藻,在东亚国家作为美食和药材被广泛食用,它含有多种生物活性化合物,具有抗炎、抗氧化和抗肥胖的特性。这表明,从饮食中摄入这种物质有助于减轻高脂饮食(HFD)引起的代谢性疾病。为了验证这一假设,我们首先分析了大型藻类的营养成分,并评估了其急性口服毒性和长期安全性。随后,我们探讨了从膳食中摄取大叶藻对高脂饮食小鼠的影响。此外,我们还利用 16S rRNA 测序进一步阐明了这种大型藻类对 HFD 引起的代谢异常具有保护作用的机制。我们的研究结果表明,S. fusiforme具有理想的营养成分,富含碳水化合物、多不饱和脂肪酸和类胡萝卜素,食用安全性高。从膳食中摄入这种植物能显著缓解高氟酸诱导的代谢紊乱。对肠道微生物群的分析表明,摄入高频分解膳食会增加固着菌的相对丰度,而减少类杆菌的相对丰度。补充 S. fusiforme 进一步加剧了这一趋势,导致与对照组和高氟日粮组相比,固着菌/类杆菌的比例更高。在属的层面上,补充了扶桑花菌素的小鼠体内的Muribaculum、乳酸杆菌、梭状芽孢杆菌_UCG_014、梭状芽孢杆菌_sp、Acetatifactor、Eubacterium_coprostanoligenes和IS_44(来自亚硝基单胞菌科)显著富集。这些研究结果支持将扶桑花菌素作为一种功能性食品来对抗高氟酸膳食诱导的代谢紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Algal Research-Biomass Biofuels and Bioproducts
Algal Research-Biomass Biofuels and Bioproducts BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
9.40
自引率
7.80%
发文量
332
期刊介绍: Algal Research is an international phycology journal covering all areas of emerging technologies in algae biology, biomass production, cultivation, harvesting, extraction, bioproducts, biorefinery, engineering, and econometrics. Algae is defined to include cyanobacteria, microalgae, and protists and symbionts of interest in biotechnology. The journal publishes original research and reviews for the following scope: algal biology, including but not exclusive to: phylogeny, biodiversity, molecular traits, metabolic regulation, and genetic engineering, algal cultivation, e.g. phototrophic systems, heterotrophic systems, and mixotrophic systems, algal harvesting and extraction systems, biotechnology to convert algal biomass and components into biofuels and bioproducts, e.g., nutraceuticals, pharmaceuticals, animal feed, plastics, etc. algal products and their economic assessment
期刊最新文献
Experimental evaluation of Scenedesmus javanensis, Halochlorella rubescens, and Chlorolobion braunii for lipid-rich biomass production and phycoremediation of dairy wastewater In vitro evaluation of functional properties of extracts of Fucus vesiculosus obtained with different conventional solvents Impact of low-dose X-ray radiation on the lipidome of Chlorella vulgaris Macroalgae and microalga blend in dogs' food: Effects on palatability, digestibility, and fecal metabolites and microbiota Scenedesmus subspicatus potential for pharmacological compounds removal from aqueous media
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1