{"title":"β-Glucosidases in specialized metabolism: Towards a new understanding of the gatekeepers of plant chemical arsenal","authors":"Angeliki Stathaki , Georgia Pantidi , Margarita Thomopoulou , Konstantinos Koudounas","doi":"10.1016/j.pbi.2024.102638","DOIUrl":null,"url":null,"abstract":"<div><div>Plants produce an exceptional multitude of chemicals to compensate with challenging environments. Despite the structural pluralism of specialized metabolism, often defensive compounds are stored <em>in planta</em> as glycosides and reactive aglycones are conditionally activated by specific β-glucosidases—a large family of enzymes with pluripotent contribution in homeostasis and a pivotal role in plant chemical defense. Typically, these detonating enzymes are characterized by exceptional substrate specificity and, in several cases, even isoenzymes exhibit differentiated molecular or biochemical characteristics. This article focuses on important intrinsic characteristics of plant β-glucosidases detonating defensive compounds and highlights recent studies with novel implications in regulatory mechanisms.</div></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":"82 ","pages":"Article 102638"},"PeriodicalIF":8.3000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624001298","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Plants produce an exceptional multitude of chemicals to compensate with challenging environments. Despite the structural pluralism of specialized metabolism, often defensive compounds are stored in planta as glycosides and reactive aglycones are conditionally activated by specific β-glucosidases—a large family of enzymes with pluripotent contribution in homeostasis and a pivotal role in plant chemical defense. Typically, these detonating enzymes are characterized by exceptional substrate specificity and, in several cases, even isoenzymes exhibit differentiated molecular or biochemical characteristics. This article focuses on important intrinsic characteristics of plant β-glucosidases detonating defensive compounds and highlights recent studies with novel implications in regulatory mechanisms.
期刊介绍:
Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.