{"title":"Nanocurcumin: A new and improved way to fight cancer and infections","authors":"Kokkarachedu Varaprasad , Natarajan Sisubalan , Tippabattini Jayaramudu , Murali M. Yallapu","doi":"10.1016/j.nanoso.2024.101352","DOIUrl":null,"url":null,"abstract":"<div><div>Nanoformulations of curcumin have garnered significant attention as a promising alternative for various health applications due to their enhanced properties over conventional curcumin formulations. Curcumin, a polyphenol organic antioxidant phytochemical extracted from turmeric, exhibits a wide range of therapeutic benefits but faces challenges such as limited solubility and bioavailability. Curcumin-based nanoformulations offer improved solubility, stability, and bioavailability, driving them a beneficial option for pharmaceutical delivery systems and targeted therapies. Recent studies have highlighted nanocurcumin as superior bacterial infections and have included multidrug-resistant strains. Moreover, nanocurcumin and its formulations show promise in cancer treatment by effectively inhibiting cancer cells and regulating key transcription factors. This review summarizes recent developments in nanocurcumin formulations and their potential in cancer therapy and antibacterial applications, emphasizing their role as innovative solutions for various health issues.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101352"},"PeriodicalIF":5.4500,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X24002646","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 0
Abstract
Nanoformulations of curcumin have garnered significant attention as a promising alternative for various health applications due to their enhanced properties over conventional curcumin formulations. Curcumin, a polyphenol organic antioxidant phytochemical extracted from turmeric, exhibits a wide range of therapeutic benefits but faces challenges such as limited solubility and bioavailability. Curcumin-based nanoformulations offer improved solubility, stability, and bioavailability, driving them a beneficial option for pharmaceutical delivery systems and targeted therapies. Recent studies have highlighted nanocurcumin as superior bacterial infections and have included multidrug-resistant strains. Moreover, nanocurcumin and its formulations show promise in cancer treatment by effectively inhibiting cancer cells and regulating key transcription factors. This review summarizes recent developments in nanocurcumin formulations and their potential in cancer therapy and antibacterial applications, emphasizing their role as innovative solutions for various health issues.
期刊介绍：
Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .
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