Effect of operating condition on the properties of ectoine particles for improving the purification process

IF 3.7 3区工程技术 Q2 ENGINEERING, CHEMICAL Chemical Engineering Research & Design Pub Date : 2024-09-11 DOI:10.1016/j.cherd.2024.09.016

Shuntaro Amari , Sae Uno , Tsubasa Kasai , Haruto Yoshida , Toshikazu Suenaga , Hiroshi Takiyama

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Abstract

Ectoine, which is produced from methane by methane-oxidizing bacteria, has attracted attention because of its many useful functions in living organisms. It is known that the purification process using alcohol-based solvents is a limiting step in the ectoine production process because of the precipitation of fine particles. This study investigated quantitatively the effects of operating conditions (cooling rate and solvent) on the properties of ectoine particles for improving the efficiency of the ectoine purification process. The experimental results showed that the properties of ectoine particles were significantly influenced by operating condition such as the cooling rate and solvent of feed solution. Furthermore, it was revealed that the critical supersaturation ratio at the nucleation using methanol was approximately ten times higher than using water. Consequently, it was found that the high critical supersaturation ratio at the nucleation induces the precipitation the fine particles that have high filtration resistance. In conclusion, we succeeded in finding the relationship between the operating conditions and properties of ectoine particles.

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操作条件对改进提纯工艺的外藤素颗粒特性的影响

由甲烷氧化细菌从甲烷中产生的外辛因其在生物体内的多种有用功能而备受关注。众所周知，在使用醇基溶剂进行提纯的过程中，由于细小颗粒的沉淀，会限制外辛生产过程。本研究定量研究了操作条件（冷却速度和溶剂）对埃克替因颗粒特性的影响，以提高埃克替因纯化过程的效率。实验结果表明，冷却速度和进料溶液的溶剂等操作条件对依托红碱颗粒的性质有显著影响。此外，实验还发现，使用甲醇成核时的临界过饱和度比使用水高出约十倍。因此，我们发现，成核时的临界过饱和度高会导致析出具有高过滤阻力的细颗粒。总之，我们成功地找到了操作条件与埃克托碱颗粒特性之间的关系。

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来源期刊

Chemical Engineering Research & Design 工程技术-工程：化工

CiteScore

6.10

自引率

7.70%

发文量

623

审稿时长

42 days

期刊介绍： ChERD aims to be the principal international journal for publication of high quality, original papers in chemical engineering. Papers showing how research results can be used in chemical engineering design, and accounts of experimental or theoretical research work bringing new perspectives to established principles, highlighting unsolved problems or indicating directions for future research, are particularly welcome. Contributions that deal with new developments in plant or processes and that can be given quantitative expression are encouraged. The journal is especially interested in papers that extend the boundaries of traditional chemical engineering.