{"title":"Phytomedicine meets nanotechnology: A cellular approach to rheumatoid arthritis treatment","authors":"Vikas Shukla , Devika Tripathi , Sakshi Sharma , Ayushi Purohit , Pratibha Singh","doi":"10.1016/j.ntm.2024.100051","DOIUrl":null,"url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is an autoimmune condition causing synovitis, joint dysfunction, and tissue deterioration. This review highlights the pathophysiology of RA, including the involvement of cellular components, cytokines, and oxidative stress, and discusses the increased cardiovascular disease (CVD) risks for RA patients. It also explores the role of lysophosphatidic acid (LPA) in RA progression. Current treatments like Disease-Modifying Anti-Rheumatic Drugs (DMRDs), biological DMARDs, and (Non-steroidal Anti-inflammatory Drugs) NASAIDs along with emerging nanomedicine strategies, are examined. The article emphasizes the potential of nanotechnology in enhancing drug delivery, aiming to improve treatment efficacy and safety for RA. This comprehensive review provides insight into complexity of RA and the promising future of nanomedicine in its management.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100051"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano TransMed","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2790676024000220","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Rheumatoid arthritis (RA) is an autoimmune condition causing synovitis, joint dysfunction, and tissue deterioration. This review highlights the pathophysiology of RA, including the involvement of cellular components, cytokines, and oxidative stress, and discusses the increased cardiovascular disease (CVD) risks for RA patients. It also explores the role of lysophosphatidic acid (LPA) in RA progression. Current treatments like Disease-Modifying Anti-Rheumatic Drugs (DMRDs), biological DMARDs, and (Non-steroidal Anti-inflammatory Drugs) NASAIDs along with emerging nanomedicine strategies, are examined. The article emphasizes the potential of nanotechnology in enhancing drug delivery, aiming to improve treatment efficacy and safety for RA. This comprehensive review provides insight into complexity of RA and the promising future of nanomedicine in its management.
类风湿性关节炎（RA）是一种自身免疫性疾病，会引起滑膜炎、关节功能障碍和组织恶化。本综述强调了 RA 的病理生理学，包括细胞成分、细胞因子和氧化应激的参与，并讨论了 RA 患者心血管疾病（CVD）风险增加的问题。报告还探讨了溶血磷脂酸（LPA）在RA进展中的作用。文章研究了目前的治疗方法，如疾病修饰抗风湿药（DMRDs）、生物 DMARDs 和（非甾体抗炎药）NASAIDs 以及新兴的纳米医学策略。文章强调了纳米技术在增强给药方面的潜力，旨在提高 RA 的治疗效果和安全性。这篇全面的综述深入揭示了 RA 的复杂性以及纳米医学在其治疗中的广阔前景。
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