Proteomic signatures of healthy dietary patterns are associated with lower risks of major chronic diseases and mortality

Kai Zhu, Rui Li, Pang Yao, Hancheng Yu, An Pan, JoAnn E. Manson, Eric B. Rimm, Walter C. Willett, Gang Liu
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Abstract

Healthy dietary patterns have been linked to a decreased risk of chronic diseases. However, it remains uncertain whether proteomic signatures can reflect proteome response to healthy diet patterns, and whether these proteomic signatures are associated with health outcomes. Using data from the UK Biobank including Olink plasma proteins, we identified substantial proteomic variation in relation to adherence to eight healthy dietary patterns. The proteomic signatures, reflecting adherence and proteome response to healthy dietary patterns, were prospectively associated with lower risks of diabetes, cardiovascular diseases, chronic respiratory diseases, chronic kidney diseases and cancers, along with longer life expectancy, even after adjusting for corresponding dietary patterns. These findings suggest proteomic signatures have the potential to complement traditional dietary assessments and deepen our understanding of the relationships between dietary patterns and chronic diseases.

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健康饮食模式的蛋白质组特征与较低的主要慢性疾病风险和死亡率有关
健康的饮食模式与慢性疾病风险的降低有关。然而,蛋白质组特征是否能反映蛋白质组对健康饮食模式的反应,以及这些蛋白质组特征是否与健康结果相关,目前仍不确定。利用英国生物库的数据(包括 Olink 血浆蛋白),我们发现了与坚持八种健康饮食模式有关的大量蛋白质组变异。这些蛋白质组特征反映了对健康饮食模式的坚持和蛋白质组反应,即使在调整了相应的饮食模式后,这些特征仍与较低的糖尿病、心血管疾病、慢性呼吸系统疾病、慢性肾脏疾病和癌症风险以及较长的预期寿命相关。这些研究结果表明,蛋白质组特征有可能补充传统的膳食评估,加深我们对膳食模式与慢性疾病之间关系的理解。
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