Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Integrative Medicine Research Pub Date : 2024-09-11 DOI:10.1016/j.imr.2024.101085
SoYoung Ahn , Parivash Jamrasi , Byunggul Lim , Ji-won Seo , Xinxing Li , Shu Jiang , Yunho Sung , Seo Hyun Ahn , Chaeyoung Shin , Dongjin Noh , Bora Jin , Seonjoo Lee , Ki Won Lee , Jin Soo Kim , Young Tae Koo , Wook Song
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Abstract

Background

Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age population; however, studies have rarely investigated this group. A mixture of Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge (CAA) may be an effective anti-fatigue supplement. However, few clinical trials have explored the anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial.

Methods

In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). Fatigue and cardiorespiratory endurance were measured at baseline, interim, and post-intervention. Fatigue-related blood biomarkers were assessed before and at the end of the intervention.

Results

A significant improvement in overall fatigue scores was observed on the fatigue severity scale (p = 0.038), multidimensional fatigue inventory (p = 0.037), and 24-hour visual analog scale (p = 0.002) in the CAA group compared to those in the placebo group. Fatigue improvement was observed in the CAA group, as well as physiological variables, such as increased maximal exercise time to exhaustion (p = 0.003), distance until exhaustion (p = 0.003), and maximum oxygen consumption (p = 0.039).

Conclusion

CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potential use of herbal supplements for treating chronic fatigue.

Trial registration

Clinical Research Information Service (CRIS, https://cris.nih.go.kr/): KCT0005613.
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草药提取物(林奈鹿、当归和黄芪)可改善慢性疲劳:随机、安慰剂对照、双盲试验
背景 慢性疲劳综合征(CFS)降低了工作年龄人群与健康相关的生活质量;然而,很少有研究对这一群体进行调查。林奈鹿、当归和黄芪的混合物(CAA)可能是一种有效的抗疲劳补充剂。然而,很少有临床试验探讨草药对人体的抗疲劳作用。因此,本研究旨在通过一项随机、安慰剂对照、双盲试验,研究 CAA 草本复方对肌肉疲劳和耐力能力的影响。方法在一项为期 8 周的试验中,80 名慢性疲劳症状患者被随机分配到 CAA 组(43.5 ± 1.2 岁)或安慰剂组(41.8 ± 1.3 岁)。分别在基线、中期和干预后测量疲劳和心肺耐力。结果与安慰剂组相比,CAA 组在疲劳严重程度量表(p = 0.038)、多维疲劳量表(p = 0.037)和 24 小时视觉模拟量表(p = 0.002)上的总体疲劳评分均有显著改善。结论CAA对慢性疲劳患者的疲劳和心肺耐力有积极而显著的影响,表明草药补充剂可能用于治疗慢性疲劳:KCT0005613。
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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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