{"title":"The unusual suspects: A systematic search for the molecular and cellular correlates of human aggression","authors":"","doi":"10.1016/j.avb.2024.102002","DOIUrl":null,"url":null,"abstract":"<div><div>Decades of research have uncovered several molecules and cell types (i.e., biomolecules) associated with aggression, violence, and hostility (AVH). In this systematic review, we aimed to identify which of these biomolecules have been predominantly studied in relation to AVH in human adults, and to obtain a general sense of the direction of the effects reported for each identified biomolecule. Eighty-one studies (out of 2914 initial abstracts) were included in the review, totaling 198 effects and 29,565 participants. Hormones, particularly testosterone and cortisol, were by far the most studied biomolecules (57.58 %), followed by cytokines (14.14 %), proteins (9.09 %), and neurotransmitters (4.55 %). Out of all extracted statistical effects, 15.1 % reported a negative association, 45.5 % reported no association, and 39.4 % reported a positive association between AVH and the biomolecules, although this pattern varied substantially for individual biomolecules. We also identified some research on biomolecules pertaining to the immune system, which could turn out to play crucial roles in advancing our understanding of AVH. These quantitative insights into the current state of biochemical research on AVH in human adults provide a basis for shaping a broader and more integrative research agenda for studying AVH.</div></div>","PeriodicalId":51360,"journal":{"name":"Aggression and Violent Behavior","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aggression and Violent Behavior","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359178924000922","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CRIMINOLOGY & PENOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Decades of research have uncovered several molecules and cell types (i.e., biomolecules) associated with aggression, violence, and hostility (AVH). In this systematic review, we aimed to identify which of these biomolecules have been predominantly studied in relation to AVH in human adults, and to obtain a general sense of the direction of the effects reported for each identified biomolecule. Eighty-one studies (out of 2914 initial abstracts) were included in the review, totaling 198 effects and 29,565 participants. Hormones, particularly testosterone and cortisol, were by far the most studied biomolecules (57.58 %), followed by cytokines (14.14 %), proteins (9.09 %), and neurotransmitters (4.55 %). Out of all extracted statistical effects, 15.1 % reported a negative association, 45.5 % reported no association, and 39.4 % reported a positive association between AVH and the biomolecules, although this pattern varied substantially for individual biomolecules. We also identified some research on biomolecules pertaining to the immune system, which could turn out to play crucial roles in advancing our understanding of AVH. These quantitative insights into the current state of biochemical research on AVH in human adults provide a basis for shaping a broader and more integrative research agenda for studying AVH.
期刊介绍:
Aggression and Violent Behavior, A Review Journal is a multidisciplinary journal that publishes substantive and integrative reviews, as well as summary reports of innovative ongoing clinical research programs on a wide range of topics germane to the field of aggression and violent behavior. Papers encompass a large variety of issues, populations, and domains, including homicide (serial, spree, and mass murder: sexual homicide), sexual deviance and assault (rape, serial rape, child molestation, paraphilias), child and youth violence (firesetting, gang violence, juvenile sexual offending), family violence (child physical and sexual abuse, child neglect, incest, spouse and elder abuse), genetic predispositions, and the physiological basis of aggression.