{"title":"Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death","authors":"Chintan Chhatbar, Michael Schulz, Roman Sankowski","doi":"10.1038/s41392-024-01985-z","DOIUrl":null,"url":null,"abstract":"<p>In their recent publication in <i>Cell</i>, Sundaram, and colleagues identified a novel role for NOD-like receptor (NLR) family CARD domain containing 5 (NLRC5) in heme-mediated cell death and inflammation.<sup>1</sup> This process is initiated by Toll-like receptors 2 and 4 on the cell surface, which induces intracellular NAD+ depletion and ROS production.</p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":null,"pages":null},"PeriodicalIF":40.8000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-01985-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In their recent publication in Cell, Sundaram, and colleagues identified a novel role for NOD-like receptor (NLR) family CARD domain containing 5 (NLRC5) in heme-mediated cell death and inflammation.1 This process is initiated by Toll-like receptors 2 and 4 on the cell surface, which induces intracellular NAD+ depletion and ROS production.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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