Moderating effects of clock genes DNA methylation on the relationship between physical activity trajectories and depressive symptoms among Chinese college students.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-30 DOI:10.1037/hea0001332

Yang Qu, Shuang Zhai, Dan Zhang, Tingting Li, Yang Xie, Shuman Tao, Yajuan Yang, Liwei Zou, Fangbiao Tao, Xiaoyan Wu

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Abstract

Objectives: To explore the 2-year physical activity trajectory of Chinese college students and further examine the longitudinal relationship between physical activity trajectory and depressive symptoms. Furthermore, our study aimed to clarify the potential role of clock genes deoxyribonucleic acid (DNA) methylation in the association between physical activity and depressive symptoms.

Method: From April 2019 to May 2021, College Student Behavior and Health Cohort Study was conducted among 1,179 students from two universities in Anhui and Jiangxi provinces. Latent Class Growth Model was applied to simulate and group physical activity in a total of five surveys. The PROCESS macro for SPSS was used to analyze the moderating effects of clock genes DNA methylation on the association between physical activity and depressive symptoms.

Results: Two physical activity trajectories were identified: "continued high level" and "gradual low level." Multinomial logistic regression analysis showed that the "gradual low level" of physical activity trajectory was independently associated with moderate-to-severe depressive symptoms. Furthermore, DNA methylation of the PER2 and CRY1 genes had negatively moderating effects between physical activity and depressive symptoms, and there was sex-specific effect for CRY1 gene.

Conclusions: Our findings suggests that long-term low physical activity was connected to more severe depressive symptoms among college students, and clock genes DNA methylation may play a negative moderating role, attenuating the positive effect of high intensity physical activity levels on depressive symptoms. In this regard, intervention programs regarding depressive symptoms among Chinese college students should consider multiple approaches such as increasing the duration and intensity of physical activity. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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时钟基因DNA甲基化对中国大学生体育锻炼轨迹与抑郁症状关系的调节作用

研究目的探讨中国大学生两年的体力活动轨迹，并进一步研究体力活动轨迹与抑郁症状之间的纵向关系。此外，我们的研究还旨在阐明时钟基因脱氧核糖核酸（DNA）甲基化在体力活动与抑郁症状之间关联中的潜在作用：方法：2019年4月至2021年5月，我们对安徽和江西两省两所高校的1179名大学生进行了大学生行为与健康队列研究。应用潜类增长模型对五次调查中的体育锻炼情况进行模拟和分组。使用 SPSS 的 PROCESS 宏分析了时钟基因 DNA 甲基化对体力活动与抑郁症状之间关系的调节作用：结果：发现了两种体力活动轨迹：结果：发现了两种体力活动轨迹："持续高水平 "和 "逐渐低水平"。多项式逻辑回归分析表明，"逐渐低水平 "的体力活动轨迹与中度至重度抑郁症状独立相关。此外，PER2和CRY1基因的DNA甲基化在体力活动和抑郁症状之间具有负向调节作用，而CRY1基因的甲基化具有性别特异性效应：我们的研究结果表明，长期低体力活动与大学生更严重的抑郁症状有关，而时钟基因 DNA 甲基化可能起着负向调节作用，削弱了高强度体力活动水平对抑郁症状的积极影响。因此，针对中国大学生抑郁症状的干预方案应考虑多种方法，如增加体育锻炼的时间和强度。(PsycInfo Database Record (c) 2024 APA, 版权所有）。

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