Feracrylum-An Unexplored Aspect of Local Drug Delivery in Treating Chronic Periodontitis: An Original Research.

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacy & bioallied sciences Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.4103/jpbs.jpbs_388_24
Karthika Janardhan, Hiral Parikh
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Abstract

Background: Targeted and efficient therapy strategies are necessary to address the global threat that chronic periodontitis poses to oral health. Antibiotic resistance is one drawback of traditional methods like scaling and root planing in conjunction with systemic antibiotics.

Techniques: A study with 120 people who had been diagnosed with chronic periodontitis was done using randomized controlled trials. The subjects were grouped as the Feracrylum group and the placebo group. Clinical measures were measured at baseline and again after 12 weeks. These parameters included gingival index, clinical attachment level, and "probing pocket depth (PD)." A 3% solution was locally applied to periodontal pockets in the Feracrylum group, whereas a saline solution was given to the placebo group.

Findings: As compared with other cohorts, the Feracrylum group showed a substantial improvement in clinical attachment level and a significant decrease in PD (P < 0.05). Although not statistically significant, the gingival index reduction in the Feracrylum group showed a tendency in the direction of better gingival health.

Conclusion: In summary, feracrylum has the potential as a localized medication delivery adjunct for chronic periodontitis, leading to positive clinical results. Larger sample numbers and longer follow-up times are required for future studies to confirm these results and maximize the use of feracrylum in periodontal treatment.

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阿魏酰亚胺--治疗慢性牙周炎的局部给药新方法:原创研究。
背景:要解决慢性牙周炎对全球口腔健康造成的威胁,就必须采取有针对性的高效治疗策略。抗生素耐药性是洗牙、根面平整和全身抗生素等传统方法的一个缺点:采用随机对照试验的方法,对 120 名被诊断为慢性牙周炎的患者进行了研究。受试者被分为阿魏酸胶组和安慰剂组。在基线和 12 周后再次测量临床指标。这些参数包括牙龈指数、临床附着水平和 "探诊袋深度(PD)"。Feracrylum 组的牙周袋局部使用 3% 的溶液,而安慰剂组则使用生理盐水:与其他组别相比,阿魏酸胶组的临床附着水平有了显著改善,PD 显著下降(P < 0.05)。尽管没有统计学意义,但阿魏酸钙组的牙龈指数下降显示出牙龈健康状况更好的趋势:总之,阿魏酸钙有可能作为慢性牙周炎的局部给药辅助疗法,带来积极的临床效果。未来的研究需要更多的样本和更长的随访时间来证实这些结果,并最大限度地将阿魏酸胶用于牙周治疗。
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