The association of ultra-processed food intake with adolescent metabolic dysfunction-associated steatotic liver disease in the NHANES.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-09-28 DOI:10.1111/ijpo.13174

Maarten Buytaert, Dimitri Declercq, Fleur Depoorter, Zerlina Cosijn, Lindsey Devisscher, Sarah Raevens, Xavier Verhelst, Hans Van Vlierberghe, Anja Geerts, Ruth De Bruyne, Sander Lefere

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Abstract

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major public health concern. A thorough analysis of the link between ultra-processed food (UPF) intake and MASLD in the adolescent population is lacking.

Methods: Adolescent participants of the National Health and Nutrition Examination Survey (NHANES) pre-pandemic cohort were included. Different controlled attenuation parameter (CAP) cut-offs were used to assess MASLD. The percentage energy intake of UPF, categorized according to the NOVA classification, to total energy intake was taken as the main outcome marker. Structural equation modelling (SEM) was used to better quantify the causal connection between UPF and liver steatosis.

Results: UPF consumption constituted a median 75% (62-86) of total energy intake. There was no significant correlation between UPF intake and CAP (ρ = 0.061, p = 0.091). The median proportion UPF intake was not associated with steatosis severity. SEM similarly yielded a weak and non-significant correlation of 0.078. In participants with MASLD, total energy intake was significantly higher (p < 0.001) and sugar-containing beverage (SCB) consumption showed a non-significant trend towards higher consumption.

Conclusions: No clinically relevant association between UPF intake and MASLD in adolescents could be demonstrated. Our results nonetheless suggest that total energy intake and consumption of SCBs are important contributors to paediatric obesity and MASLD.

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在国家健康调查（NHANES）中，超加工食品摄入量与青少年代谢功能障碍相关脂肪肝的关系。

简介代谢功能障碍相关性脂肪性肝病（MASLD）已成为公众关注的主要健康问题。目前还缺乏对青少年超加工食品（UPF）摄入量与代谢性脂肪肝之间关系的全面分析：方法：纳入全国健康与营养调查（NHANES）大流行前队列中的青少年参与者。采用不同的受控衰减参数（CAP）临界值来评估MASLD。根据诺瓦分类法划分的 UPF 能量摄入量占总能量摄入量的百分比被作为主要结果指标。为了更好地量化UPF与肝脏脂肪变性之间的因果关系，采用了结构方程模型（SEM）：UPF摄入量占总能量摄入量的中位数为75%（62-86）。UPF摄入量与CAP之间无明显相关性（ρ = 0.061，p = 0.091）。UPF摄入量的中位比例与脂肪变性的严重程度无关。同样，SEM 也得出了 0.078 的微弱且不显著的相关性。在患有脂肪肝的参与者中，总能量摄入量明显更高（p 结论：UPF 与脂肪肝的严重程度没有临床相关性：在青少年中，UPF 摄入量与 MASLD 之间没有临床相关性。不过，我们的研究结果表明，总能量摄入量和 SCB 消费量是导致儿童肥胖和 MASLD 的重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.