Design of Bionanomaterial of Chitosan Carbohydrate Polymer Composited with Broccoli Extract and Zinc Oxide Nanoparticles: Anticancer Activity in Human Osteosarcoma.

IF 3.1 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Applied Biochemistry and Biotechnology Pub Date : 2024-10-01 DOI:10.1007/s12010-024-05066-3

Muthanna O Hussein, Ahmed Saud Abdulhameed

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Abstract

In the current research, a chitosan/broccoli extract/ZnO nanoparticle (CH/BE/ZnO) bionanocomposite was created. The physicochemical properties of CH/BE/ZnO bionanocomposite were investigated using a variety of methods, including field emission scanning electron microscopy (FESEM), elemental analysis (CHN-O), X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), Brunauer-Emmett-Teller (BET), and transmission electron microscopy (TEM). The CH/BE/ZnO bionanocomposite's biological activity was assessed by examining its cytotoxicity capabilities against a bone cancer cell line (MG63). The total pore volume and specific surface area of CH/BE/ZnO are 0.134 cm³/g and 16.99 m²/g, respectively. The IC50 results for CH/BE/ZnO bionanocomposite in bone cancer investigations using the MTT test against the MG63 cell line was 115 μg/mL. The results indicate that the CH/BE/ZnO bionanocomposite is an effective chemotherapeutic agent against human osteosarcoma. The CH/BE/ZnO bionanocomposite showed high performance and structure, which means innovating nanomaterial agents for biological applications in the future.

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壳聚糖碳水化合物聚合物与西兰花提取物和纳米氧化锌复合物的仿生材料设计：对人类骨肉瘤的抗癌活性。

本研究创建了壳聚糖/西兰花提取物/氧化锌纳米粒子（CH/BE/ZnO）仿生复合材料。研究采用了多种方法，包括场发射扫描电子显微镜（FESEM）、元素分析（CHN-O）、X射线衍射（XRD）、傅立叶变换红外光谱（FTIR）、Brunauer-Emmett-Teller（BET）和透射电子显微镜（TEM），对壳聚糖/西兰花提取物/氧化锌仿生复合材料的理化性质进行了研究。通过检测 CH/BE/ZnO 仿生复合材料对骨癌细胞株（MG63）的细胞毒性能力，对其生物活性进行了评估。CH/BE/ZnO 的总孔体积和比表面积分别为 0.134 立方厘米/克和 16.99 平方米/克。CH/BE/ZnO 仿生复合材料在骨癌研究中使用 MTT 试验对 MG63 细胞系的 IC50 值为 115 μg/mL。结果表明，CH/BE/ZnO 仿生复合材料是一种有效的人类骨肉瘤化疗药物。CH/BE/ZnO仿生复合材料表现出了高性能和高结构性，这意味着未来在生物应用领域的纳米材料制剂的创新。

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来源期刊

Applied Biochemistry and Biotechnology 工程技术-生化与分子生物学

CiteScore

5.70

自引率

6.70%

发文量

460

审稿时长

5.3 months

期刊介绍： This journal is devoted to publishing the highest quality innovative papers in the fields of biochemistry and biotechnology. The typical focus of the journal is to report applications of novel scientific and technological breakthroughs, as well as technological subjects that are still in the proof-of-concept stage. Applied Biochemistry and Biotechnology provides a forum for case studies and practical concepts of biotechnology, utilization, including controls, statistical data analysis, problem descriptions unique to a particular application, and bioprocess economic analyses. The journal publishes reviews deemed of interest to readers, as well as book reviews, meeting and symposia notices, and news items relating to biotechnology in both the industrial and academic communities. In addition, Applied Biochemistry and Biotechnology often publishes lists of patents and publications of special interest to readers.