First-degree family history of cancers in patients with stage I endometrial carcinoma. Prevalence and prognostic impact

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI:10.1007/s00404-024-07728-3
Abdelrahman Yousif, Zuber D. Mulla, Julia Pudar, Muneer Elshaikh, Remonda Khalil-Moawad, Mohamed A. Elshaikh
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Abstract

Background

We aimed to study the impact of first-degree family history on patients with endometrial cancer.

Methods

We conducted a retrospective chart review from January 1990 to June 2016, comparing stage I endometrial cancer patients with and without a sporadic family history of cancers. We collected the patients’ demographic information, tumor characteristics, and treatment plans. During the follow-up period, patient information on tumor recurrence and survival was collected. The chi-square test was used to assess the associations between categorical variables. The Cox proportional hazards regression model was used to estimate multivariate-adjusted hazard ratios (95% confidence interval (CI)).

Results

Among the 1737 patients with stage I endometrial cancer, 709 had a positive first-degree family history of cancers and 1028 had negative family history (FH) of cancers. Patients with positive FH were more likely to be older, have stage IB disease, and receive adjuvant radiotherapy; however, the difference was not statistically significant. At 5 years follow up, patients with a positive family history had longer time to recurrence (TTR) than their negative FH counterparts. Maternal family history of cancer was the most common, followed by a sister’s history of cancer, paternal history, brother’s history, and offspring history of cancer. Breast, endometrial, and colon cancers are the most common cancers among first-degree relatives.

Conclusion

Endometrial cancer patients with sporadic first-degree FH of cancers share similar demographics and tumor characteristics compared to their counterpart with slightly increased likelihood to be older, with stage IB disease and have a longer TTR compared to their negative counterpart.

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I 期子宫内膜癌患者的一级癌症家族史。发病率和对预后的影响。
背景:我们旨在研究一级家族史对子宫内膜癌患者的影响:我们旨在研究一级家族史对子宫内膜癌患者的影响:我们对 1990 年 1 月至 2016 年 6 月期间的病历进行了回顾性分析,比较了有和无散发性癌症家族史的 I 期子宫内膜癌患者。我们收集了患者的人口统计学信息、肿瘤特征和治疗方案。在随访期间,我们还收集了患者的肿瘤复发和生存信息。我们使用卡方检验来评估分类变量之间的关联。采用考克斯比例危险回归模型估算多变量调整后的危险比(95%置信区间(CI)):结果:在1737名I期子宫内膜癌患者中,709人有阳性一级癌症家族史,1028人有阴性癌症家族史(FH)。有阳性家族史的患者更有可能年龄较大、患有IB期疾病并接受辅助放疗,但差异无统计学意义。在5年的随访中,阳性家族史患者的复发时间(TTR)长于阴性家族史患者。母系癌症家族史最常见,其次是姐妹癌症史、父系癌症史、兄弟癌症史和后代癌症史。乳腺癌、子宫内膜癌和结肠癌是一级亲属中最常见的癌症:子宫内膜癌患者的人口统计学特征和肿瘤特征与他们的同类患者相似,但与阴性同类患者相比,年龄稍大、IB 期疾病和 TTR 较长的可能性略有增加。
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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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