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Real-world data of perioperative complications in prepectoral implant-based breast reconstruction: a prospective cohort study. 前胸植入物乳房再造术围手术期并发症的真实数据:前瞻性队列研究。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-07 DOI: 10.1007/s00404-024-07807-5
Moritz Hamann, Elena Bensmann, Anne Andrulat, Jasmin Festl, Gitti Saadat, Evelyn Klein, Dimitrios Chronas, Michael Braun

Purpose: To analyze complications and potential risk factors associated with immediate prepectoral direct-to-implant breast reconstruction (DTIBR).

Methods: 295 patients (326 operated breasts) with DTIBR between March 2021 and December 2023 were included in this prospective study. Postoperative complications (postoperative bleeding, seroma, infection, necrosis, wound dehiscence, implant exchange/loss) were analyzed for potential risk factors by descriptive and logistic regression analyses.

Results: The implant was covered by TiLOOP® Bra Pocket in 227 breasts (69.6%), by "dual-plane" technique in 20 breasts (6.1%), by acellular dermal matrix (ADM) in 1 breast (0.3%). No additional support was used for 78 breasts (23.9%). The use of mesh did not increase the risk for complications. Major complications requiring surgical revision occurred due to postoperative bleeding in 22 (6.7%), seroma in 2 (0.6%), infection in 13 (4.0%), necrosis in 10 (3.1%), and wound dehiscence in 10 (3.1%) breasts. Thirteen (4.0%) implants were exchanged, and 5 (1.5%) were explanted without substitution. One patient had to switch to autologous reconstruction due to skin necrosis. The main reasons for the removal/exchange of implants were infections (11 breasts, 3.4%) and necrosis (4 breasts, 1.2%). The risk for necrosis, infection, and wound dehiscence was mainly associated with the type of incision, especially skin-reducing incisions, and body mass index (BMI) ≥ 30 kg/m2.

Conclusion: Severe complications occurred primarily in patients with a BMI ≥ 30 kg/m2 and when skin-reducing surgical techniques were performed.

Trial registry: This study was retrospectively registered at the German Clinical Trials Register (DRKS) on 20.06.2024.

Drks-id: DRKS00034493. https://drks.de/search/de/trial/DRKS00034493 .

目的:分析与胸前即刻直接植入乳房重建术(DTIBR)相关的并发症和潜在风险因素。方法:这项前瞻性研究纳入了2021年3月至2023年12月期间接受DTIBR的295名患者(326个手术乳房)。通过描述性分析和逻辑回归分析,对术后并发症(术后出血、血清肿、感染、坏死、伤口裂开、假体置换/丢失)的潜在风险因素进行了分析:227 例乳房(69.6%)使用了 TiLOOP® 胸袋覆盖假体,20 例乳房(6.1%)使用了 "双平面 "技术,1 例乳房(0.3%)使用了非细胞真皮基质(ADM)。78个乳房(23.9%)未使用额外的支撑物。使用网片不会增加并发症的风险。需要进行手术翻修的主要并发症有:22 例(6.7%)术后出血、2 例(0.6%)血清肿、13 例(4.0%)感染、10 例(3.1%)坏死、10 例(3.1%)伤口裂开。13例(4.0%)患者更换了假体,5例(1.5%)患者在未更换假体的情况下进行了手术。一名患者因皮肤坏死不得不改用自体重建。移除/更换假体的主要原因是感染(11 例乳房,3.4%)和坏死(4 例乳房,1.2%)。坏死、感染和伤口开裂的风险主要与切口类型(尤其是缩减皮肤的切口)和体重指数(BMI)≥ 30 kg/m2有关:结论:严重并发症主要发生在体重指数(BMI)≥ 30 kg/m2的患者和采用减张皮肤手术技术的患者:本研究于2024年6月20日在德国临床试验注册中心(DRKS)进行了回顾性注册:https://drks.de/search/de/trial/DRKS00034493 .
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引用次数: 0
High-altitude hypoxia exposure alters follicular metabolome and oocyte developmental potential in women. 高海拔缺氧会改变女性卵泡代谢组和卵母细胞发育潜能。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-06 DOI: 10.1007/s00404-024-07695-9
Zhengfang Xiong, Xiaolei Liu, Qingdi Wang

Purpose: To explore the effects of high-altitude hypoxia on the microenvironment of oocyte development and fertilization potential, we compared the metabolomic patterns of follicular fluid from women living in different altitude areas and traced their oocyte maturation and subsequent development.

Methods: A total of 315 clinical cases were collected and divided into three groups according to their residence altitudes: 138 cases in low-altitude (< 2300 m) group, 100 cases in middle-altitude (2300-2800 m) group and 77 cases in high-altitude (> 2800 m) group. The clinical outcomes were statistically estimated, including hormonal level, oocyte maturation, in vitro fertilization, and embryo development. Meanwhile, a metabolomic analysis was performed on the follicular fluid of women from different groups using ultra-high-performance liquid chromatography and high-resolution mass spectrometry and differential metabolites were analyzed through the KEGG pathway.

Results: The clinical data indicated that the physical condition and reproductive hormone secretion were similar among different groups. Although personalized gonadotropin-releasing hormone strategies were applied, the numbers of antral follicles and obtained oocytes were not impacted by the residence altitude change. In in vitro culture, the maturing rate, fertility rate and cleavage rate of high-altitude group were compared with the other groups. However, the rates of high-quality embryo, formative blastocyst, and available blastocyst were gradually decreased with the rise of residence altitude. Metabolome analysis identified 1193 metabolites in female follicular fluid. Differential analysis indicated that metabolic components in follicular fluid were remarkably changed with the elevation of residence altitude. These differential metabolites were closely related with amino acid metabolism, protein digestion and absorption, oocyte meiosis and steroid biosynthesis.

Conclusion: The residence altitude alters the microenvironment of follicular fluid, which could damage the oocyte developmental potential. This study provides diagnostic basis and therapeutic targets for research on female oocyte and embryo development.

目的:为了探讨高海拔缺氧对卵母细胞发育和受精潜能微环境的影响,我们比较了生活在不同海拔地区的妇女卵泡液的代谢组学模式,并追踪其卵母细胞的成熟和后续发育过程:方法:共收集了 315 例临床病例,并根据居住海拔高度将其分为三组:低海拔(2800 米)组 138 例。对临床结果进行统计,包括激素水平、卵母细胞成熟度、体外受精和胚胎发育。同时,利用超高效液相色谱法和高分辨质谱法对不同组别妇女的卵泡液进行了代谢组学分析,并通过 KEGG 通路对差异代谢物进行了分析:结果:临床数据表明,不同组的身体状况和生殖激素分泌情况相似。虽然采用了个性化的促性腺激素释放激素策略,但前房卵泡数和获得的卵母细胞数并未受到居住海拔高度变化的影响。在体外培养中,高海拔组的成熟率、受精率和卵裂率与其他组进行了比较。但是,优质胚胎率、形成囊胚率和可用囊胚率随着居住海拔的升高而逐渐降低。代谢组分析确定了女性卵泡液中的 1193 种代谢物。差异分析表明,随着居住海拔的升高,卵泡液中的代谢成分发生了显著变化。这些差异代谢物与氨基酸代谢、蛋白质消化吸收、卵母细胞减数分裂和类固醇生物合成密切相关:结论:居住海拔会改变卵泡液的微环境,从而损害卵母细胞的发育潜能。这项研究为女性卵母细胞和胚胎发育研究提供了诊断依据和治疗目标。
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引用次数: 0
Evaluation of the clinical utility of NIPT-plus and analysis of adverse pregnancy outcomes. 评估 NIPT-plus 的临床实用性并分析不良妊娠结局。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-06 DOI: 10.1007/s00404-024-07811-9
Le Zhang, Bozhen Chang, Lixia Wang, Gulinazi Mijiti, Kuerlan Bahetibieke, Shuyuan Xue

Purpose: To evaluate the performance of NIPT-plus in detecting fetal aneuploidies and CNVs and analyze the factors influencing adverse pregnancy outcomes.

Methods: The retrospectively analyzed 8726 pregnant women who underwent NIPT-plus for fetal screening were classified into low- (who tested voluntarily) and high-risk (women with advanced age, abnormal ultrasound, abnormal serological screening, or a combination of indications) groups. Basic maternal information, prenatal findings, and pregnancy outcomes were recorded. NIPT-plus performance was assessed for various chromosomal abnormalities and the association between the fetal fraction and adverse pregnancy outcomes.

Results: Thirty-six (0.4%) patients had failed tests; 144 (1.65%) positive cases were detected, of which, 107 (74.31%) opted for invasive testing, and 51 were verified as true positives. The total positive predictive value was 45.45% and 48.65% in the low- and high-risk groups, respectively, and the difference was not significant. Among the subsequent cases with abnormal ultrasound monitoring, two false-negative cases were identified, and pathogenic CNV diagnosis was confirmed through amniocentesis, resulting in pregnancy termination. Fetal fraction was not associated with an increased adverse pregnancy outcome risk; however, ethnic differences may affect pregnancy outcomes.

Conclusion: NIPT-plus technology use is no longer restricted to high-risk pregnant women, and it may produce false-positive results. The stakeholders should be aware of this limitation. The uncertainties and potential risks of the test results should be explained to the test takers to enable informed decision making and to minimize unnecessary anxiety and concerns. Ethnicity may influence adverse pregnancy outcomes in local multiracial settings.

目的:评估NIPT-plus在检测胎儿非整倍体和CNV方面的性能,并分析不良妊娠结局的影响因素:方法:回顾性分析了8726名接受NIPT-plus胎儿筛查的孕妇,并将其分为低危(自愿接受检测)和高危(高龄、超声检查异常、血清学筛查异常或合并有适应症)两组。记录了产妇的基本信息、产前检查结果和妊娠结局。对NIPT-plus的各种染色体异常表现以及胎儿分型与不良妊娠结局之间的关联进行了评估:36例(0.4%)患者检测失败;检测出144例(1.65%)阳性病例,其中107例(74.31%)选择了侵入性检测,51例被证实为真阳性。低风险组和高风险组的总阳性预测值分别为 45.45% 和 48.65%,差异不显著。在随后的超声监测异常病例中,发现了两例假阴性病例,并通过羊膜穿刺术确诊了致病性 CNV,导致妊娠终止。胎儿分型与不良妊娠结局风险增加无关;然而,种族差异可能会影响妊娠结局:结论:NIPT-plus 技术的使用不再局限于高风险孕妇,它可能会产生假阳性结果。相关人员应认识到这一局限性。应向检测者解释检测结果的不确定性和潜在风险,以便其在知情的情况下做出决定,并尽量减少不必要的焦虑和担忧。在当地多种族环境中,种族可能会影响不良妊娠结局。
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引用次数: 0
Perinatal outcomes in pregnancies achieved after fertility treatments with and without diet-controlled GDM. 接受生育治疗后妊娠的围产期结果,有无饮食控制的 GDM。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-05 DOI: 10.1007/s00404-024-07780-z
Baraah Abu Karen, Naama Steiner, Reut Rotem, Yael Baumfeld, A Y Weintraub, Tamar Eshkoli

Objective: To evaluate the rates of adverse perinatal outcomes among women who conceived after fertility treatments with and without diet-controlled GDM.

Methods: In this retrospective population-based cohort study, all pregnancies of non-diabetic and diet-controlled GDM women who conceived after fertility treatments (in-vitro fertilization - IVF and ovulation induction - OI) and delivered between the years 1996-2016 in a tertiary medical center, were included. Pregnancies of women with pre-gestational diabetes mellitus, and those complicated with gestational diabetes mellitus A2, multiple pregnancies, congenital malformations and those lacking prenatal care, were excluded. Demographical, clinical, and obstetrical characteristics were recorded, and pregnancy complications and adverse perinatal outcomes were compared between the groups. Multivariate logistic regression models were used to control for confounders. Statistical analyses were performed using logistic regression to control for potential confounders. A p-value of < 0.05 was considered statistically significant.

Results: During the study period, 6254 deliveries met the inclusion criteria, 10.23% of them (n = 640) had diet-controlled GDM. Pregnancies with diet-controlled GDM were found to be associated with significantly higher rates of hypertensive disorders of pregnancy (15.6% vs. 9.8%, p < 0.001), polyhydramnios (5.9% vs. 2.7%, p < 0.001), and cesarean deliveries (40.8% vs. 31.9%, p < 0.001). Diet-controlled GDM was also found to be an independent protective factor against perinatal mortality (aOR = 0.22, 95% Cl 0.05-0.92, P = 0.04) possibly due to the more intensive monitoring and management typically provided to women undergoing fertility treatments. This close care may mitigate some of the risks associated with ART, leading to improved perinatal outcomes.

Conclusion: Among pregnancies achieved after fertility treatments, diet-controlled GDM was associated with reduced perinatal mortality and higher rates of certain pregnancy complications. These findings highlight the importance of close monitoring and careful management of women with diet-controlled GDM, as it may help mitigate risks associated with ART pregnancies. Further research is needed to understand the mechanisms behind these outcomes and to optimize management strategies for this specific population.

目的评估在接受生育治疗后受孕的妇女中,饮食控制型 GDM 和非饮食控制型 GDM 妇女围产期不良结局的发生率:在这项基于人群的回顾性队列研究中,纳入了 1996-2016 年间在一家三级医疗中心接受生育治疗(体外受精-IVF 和促排卵-OI)后受孕并分娩的所有非糖尿病和饮食控制型 GDM 妇女的妊娠。不包括妊娠前患有糖尿病、并发妊娠糖尿病 A2、多胎妊娠、先天性畸形和缺乏产前护理的孕妇。记录了各组的人口学、临床和产科特征,并比较了各组之间的妊娠并发症和围产期不良结局。采用多变量逻辑回归模型来控制混杂因素。使用逻辑回归进行统计分析,以控制潜在的混杂因素。P值小于0.05为具有统计学意义:在研究期间,有 6254 例分娩符合纳入标准,其中 10.23% 的孕妇(n = 640)患有饮食控制型 GDM。研究发现,饮食控制型 GDM 孕妇的妊娠高血压疾病(15.6% 对 9.8%,P < 0.001)、多羊水(5.9% 对 2.7%,P < 0.001)和剖宫产(40.8% 对 31.9%,P < 0.001)发生率明显较高。研究还发现,饮食控制的 GDM 是围产期死亡率的一个独立保护因素(aOR = 0.22,95% Cl 0.05-0.92,P = 0.04),这可能是由于通常会对接受生育治疗的妇女进行更严格的监测和管理。这种密切护理可能会减轻抗逆转录病毒疗法的一些相关风险,从而改善围产期结局:结论:在接受生育治疗后妊娠的妇女中,饮食控制的 GDM 与围产儿死亡率降低和某些妊娠并发症发生率升高有关。这些发现强调了对饮食控制型 GDM 妇女进行密切监测和精心管理的重要性,因为这可能有助于降低与 ART 妊娠相关的风险。要了解这些结果背后的机制,并针对这一特殊人群优化管理策略,还需要进一步的研究。
{"title":"Perinatal outcomes in pregnancies achieved after fertility treatments with and without diet-controlled GDM.","authors":"Baraah Abu Karen, Naama Steiner, Reut Rotem, Yael Baumfeld, A Y Weintraub, Tamar Eshkoli","doi":"10.1007/s00404-024-07780-z","DOIUrl":"https://doi.org/10.1007/s00404-024-07780-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the rates of adverse perinatal outcomes among women who conceived after fertility treatments with and without diet-controlled GDM.</p><p><strong>Methods: </strong>In this retrospective population-based cohort study, all pregnancies of non-diabetic and diet-controlled GDM women who conceived after fertility treatments (in-vitro fertilization - IVF and ovulation induction - OI) and delivered between the years 1996-2016 in a tertiary medical center, were included. Pregnancies of women with pre-gestational diabetes mellitus, and those complicated with gestational diabetes mellitus A2, multiple pregnancies, congenital malformations and those lacking prenatal care, were excluded. Demographical, clinical, and obstetrical characteristics were recorded, and pregnancy complications and adverse perinatal outcomes were compared between the groups. Multivariate logistic regression models were used to control for confounders. Statistical analyses were performed using logistic regression to control for potential confounders. A p-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>During the study period, 6254 deliveries met the inclusion criteria, 10.23% of them (n = 640) had diet-controlled GDM. Pregnancies with diet-controlled GDM were found to be associated with significantly higher rates of hypertensive disorders of pregnancy (15.6% vs. 9.8%, p < 0.001), polyhydramnios (5.9% vs. 2.7%, p < 0.001), and cesarean deliveries (40.8% vs. 31.9%, p < 0.001). Diet-controlled GDM was also found to be an independent protective factor against perinatal mortality (aOR = 0.22, 95% Cl 0.05-0.92, P = 0.04) possibly due to the more intensive monitoring and management typically provided to women undergoing fertility treatments. This close care may mitigate some of the risks associated with ART, leading to improved perinatal outcomes.</p><p><strong>Conclusion: </strong>Among pregnancies achieved after fertility treatments, diet-controlled GDM was associated with reduced perinatal mortality and higher rates of certain pregnancy complications. These findings highlight the importance of close monitoring and careful management of women with diet-controlled GDM, as it may help mitigate risks associated with ART pregnancies. Further research is needed to understand the mechanisms behind these outcomes and to optimize management strategies for this specific population.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the complications rate of different suture-passing techniques at the time of sacrospinous ligament fixation: a systematic review and meta-analysis. 骶棘韧带固定时不同缝合技术并发症发生率的比较:系统回顾和荟萃分析。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-05 DOI: 10.1007/s00404-024-07788-5
Elaheh Amiri, Parvin Bastani, Fatemeh Mallah, Helia Mostafaei, Hanieh Salehi-Pourmehr

Objective: This study was designed to assess the complications raised in different suture-passing techniques when fixating the Sacrospinous ligament for pelvic organ prolapse (POP).

Search strategy: We searched PubMed, Embase, Scopus, Web of Sciences, ProQuest, Google Scholar, and Cochrane Library, and performed a systematic review meta-analysis to assess complications when implementing different suture passings in fixating the sacrospinous ligament.

Selection criteria: The inclusion and exclusion criteria for literature screening were predetermined to allow for a more rigorous process. Interventions should include sacrospinous fixation (SSF) as a point of attachment for POP. To eliminate confounding bias and effect modification, at least one arm must include SSLF without mesh or graft.

Data collection and analysis: The primary endpoint used was the need for reoperation, nerve injury, hematoma, and the need for blood transfusion. The secondary endpoint was study screening. For eligible articles, data were extracted and summarized independently by two reviewers.

Main results: The systemic review used the data from 125 studies, including 10,216 cases. The reoperation rate was 1.2% overall, with higher rates in the Shutt Suture Punch System, Laurus, and Anchorsure. The nerve injury rate was 3.8%, with Capio having the highest rate. The hematoma rate was 1.7%, with Laurus and Raz anchoring showing higher rates. Blood transfusion rates were higher with Modified Deschamps and Deschamps devices.

Conclusions: Complications related to suture passing are increased when suture capturing is the method applied in passing the suture through the sacrospinous ligament.

研究目的本研究旨在评估在固定骶棘韧带治疗盆腔脏器脱垂(POP)时不同缝合技术引起的并发症:我们检索了PubMed、Embase、Scopus、Web of Sciences、ProQuest、Google Scholar和Cochrane图书馆,并进行了系统性回顾荟萃分析,以评估在固定骶棘韧带时采用不同缝合方式所引起的并发症:文献筛选的纳入和排除标准是预先确定的,以便进行更严格的筛选。干预措施应包括将骶棘固定(SSF)作为 POP 的附着点。为消除混杂偏倚和效应修饰,至少有一个臂必须包括不含网片或移植物的骶棘固定术:数据收集与分析:主要终点是再次手术、神经损伤、血肿和输血的需要。次要终点是研究筛选。对于符合条件的文章,由两名审稿人独立进行数据提取和总结:主要结果:系统性综述使用了 125 项研究的数据,包括 10,216 个病例。总的再手术率为1.2%,其中Shutt缝合打孔系统、Laurus和Anchorsure的再手术率较高。神经损伤率为 3.8%,其中 Capio 的神经损伤率最高。血肿发生率为 1.7%,其中 Laurus 和 Raz 固定的发生率较高。改良德尚和德尚装置的输血率较高:结论:当采用缝合捕捉法将缝线穿过骶棘韧带时,与缝线穿过相关的并发症会增加。
{"title":"Comparison of the complications rate of different suture-passing techniques at the time of sacrospinous ligament fixation: a systematic review and meta-analysis.","authors":"Elaheh Amiri, Parvin Bastani, Fatemeh Mallah, Helia Mostafaei, Hanieh Salehi-Pourmehr","doi":"10.1007/s00404-024-07788-5","DOIUrl":"https://doi.org/10.1007/s00404-024-07788-5","url":null,"abstract":"<p><strong>Objective: </strong>This study was designed to assess the complications raised in different suture-passing techniques when fixating the Sacrospinous ligament for pelvic organ prolapse (POP).</p><p><strong>Search strategy: </strong>We searched PubMed, Embase, Scopus, Web of Sciences, ProQuest, Google Scholar, and Cochrane Library, and performed a systematic review meta-analysis to assess complications when implementing different suture passings in fixating the sacrospinous ligament.</p><p><strong>Selection criteria: </strong>The inclusion and exclusion criteria for literature screening were predetermined to allow for a more rigorous process. Interventions should include sacrospinous fixation (SSF) as a point of attachment for POP. To eliminate confounding bias and effect modification, at least one arm must include SSLF without mesh or graft.</p><p><strong>Data collection and analysis: </strong>The primary endpoint used was the need for reoperation, nerve injury, hematoma, and the need for blood transfusion. The secondary endpoint was study screening. For eligible articles, data were extracted and summarized independently by two reviewers.</p><p><strong>Main results: </strong>The systemic review used the data from 125 studies, including 10,216 cases. The reoperation rate was 1.2% overall, with higher rates in the Shutt Suture Punch System, Laurus, and Anchorsure. The nerve injury rate was 3.8%, with Capio having the highest rate. The hematoma rate was 1.7%, with Laurus and Raz anchoring showing higher rates. Blood transfusion rates were higher with Modified Deschamps and Deschamps devices.</p><p><strong>Conclusions: </strong>Complications related to suture passing are increased when suture capturing is the method applied in passing the suture through the sacrospinous ligament.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of celiac disease on fertility and pregnancy: an Italian survey. 乳糜泻对生育和怀孕的影响:一项意大利调查。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-05 DOI: 10.1007/s00404-024-07781-y
Martina Arcieri, Carlotta Abrami, Annalisa Graziano, Stefano Restaino, Elisa Barbui, Elisa Rizzante, Silvia D'Ippolito, Giuseppe Vizzielli, Lorenza Driul

Background: Celiac disease (CD) is an inflammatory enteropathy that has been associated to obstetric and gynecological disorders. However, it is still not adequately tested by gynecologists due to the misconception that it is solely a gastrointestinal disease. This underestimation requires the development of targeted interventions.

Purpose: This study aims to evaluate the association between CD and obstetric/gynecological complications, highlight the importance of informing patients about CD manifestations, and assess the patient satisfaction with the information provided by healthcare professionals on the disease.

Methods: A digital survey was administered to celiac women via the Italian Celiac Association's website.

Results: We analyzed 493 questionnaires. Obstetric and gynecological disorders led to the diagnosis of CD in 11.7% of interviewed. The study revealed that untreated CD patients are more predisposed to miscarriages (41.8% vs 34% before/after diagnosis, respectively, p = 0.111), anemia in pregnancy (71.4% vs 40.4% before/after diagnosis, respectively, p < 0.001) and the risk of low birth weight (newborns weighing < 1500 g were 4.0% before and 1.1% after the gluten-free diet, p = 0.028). Women with CD, both before and after gluten-free diet, had higher infertility rates (about 19%) than the general population. Additionally, 73% of interviewees were dissatisfied with the information they received from health professionals about the reproductive implications of CD.

Conclusion: Our research contributes to a deeper understanding of the intersection between CD and reproductive outcomes, highlighting the main obstetric and gynecological problems related to it. It emphasizes the importance of patient's perspective and the need for greater awareness about celiac disease from healthcare workers.

背景:乳糜泻(CD)是一种炎症性肠病,与妇产科疾病有关。然而,由于人们误认为乳糜泻仅仅是一种胃肠道疾病,妇科医生仍未对其进行充分检测。目的:本研究旨在评估乳糜泻与妇产科并发症之间的关联,强调告知患者乳糜泻表现的重要性,并评估患者对医护人员提供的疾病信息的满意度:方法:通过意大利乳糜泻协会网站对乳糜泻妇女进行数字调查:我们对 493 份问卷进行了分析。11.7%的受访者因产科和妇科疾病而被诊断为乳糜泻。研究显示,未经治疗的 CD 患者更容易流产(诊断前/后分别为 41.8% vs 34%,P = 0.111)、妊娠贫血(诊断前/后分别为 71.4% vs 40.4%,P 结论:我们的研究有助于加深对 CD 患者的了解:我们的研究有助于更深入地了解 CD 与生殖结果之间的关系,突出了与之相关的主要妇产科问题。它强调了患者视角的重要性以及医护人员提高对乳糜泻认识的必要性。
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引用次数: 0
Paracetamol versus ibuprofen for early postpartum pain control: a randomized controlled trial. 对乙酰氨基酚与布洛芬用于产后早期疼痛控制:随机对照试验。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-05 DOI: 10.1007/s00404-024-07797-4
Shai Ram, Dotan Madar, Hila Shalev Ram, Goni Peleg, Yotam Lior, Ayelet Greenfeld, Gala Yakov, Yariv Yogev, Sharon Maslovitz

Introduction: To evaluate the effectiveness of paracetamol and ibuprofen as non-opioid treatments for postpartum pain control after vaginal delivery.

Materials and methods: This randomized controlled study at a university-affiliated medical center involved parturient who received blindly oral tablets of either 1000 mg of paracetamol or 400 mg of ibuprofen, post-vaginal birth. Pain levels were assessed using a numeric rating scale (NRS) at four time points: before treatment, and 1, 4, and 6 h post-treatment (T0, T1, T4, and T6, respectively). We also compared the need for additional analgesia, breastfeeding initiation, mobilization, and urination following the delivery between the groups. To ensure statistical power, the study was designed to detect differences of one point on the NRS with at least 37 women per group.

Results: A total of 107 women participated, including paracetamol (n = 52) and ibuprofen (n = 55) groups. Demographics and perinatal outcomes were similar across groups. No significant differences were found in the interval between delivery and request for pain control (8 ± 6-10.5 and 11 ± 6-16 h for the paracetamol and the ibuprofen, respectively, P = .13). Pain levels on the NRS were similar for both groups at all intervals. There were also no group differences in the time to the initiation of breastfeeding, mobilization, urination, or the need for additional analgesia.

Conclusion: Both, paracetamol and ibuprofen, can be considered equivalent and effective non-opioid alternatives for postpartum pain control. REGISTRY AT CLINICALTRIALS.GOV: (NCT04653506), https://register.

Clinicaltrials: gov/prs/beta/studies/S000AFOR00000066/recordSummary .

引言评估扑热息痛和布洛芬作为非阿片类药物治疗阴道分娩后产后疼痛控制的有效性:这项随机对照研究是在一所大学附属医疗中心进行的,产妇在阴道分娩后盲目口服 1000 毫克扑热息痛片剂或 400 毫克布洛芬片剂。在四个时间点(治疗前、治疗后 1、4 和 6 小时,分别为 T0、T1、T4 和 T6)使用数字评分量表 (NRS) 评估疼痛程度。我们还比较了两组产妇在分娩后对额外镇痛、母乳喂养、活动和排尿的需求。为确保统计能力,研究旨在检测每组至少 37 名产妇在 NRS 上一个点的差异:共有 107 名产妇参加,包括扑热息痛组(52 人)和布洛芬组(55 人)。各组的人口统计学和围产期结果相似。从分娩到要求止痛的时间间隔无明显差异(扑热息痛组和布洛芬组分别为 8 ± 6-10.5 小时和 11 ± 6-16 小时,P = .13)。在所有时间间隔内,两组的 NRS 疼痛水平相似。在开始母乳喂养、活动、排尿或需要额外镇痛的时间上也没有组间差异:结论:扑热息痛和布洛芬可被视为控制产后疼痛的同等有效的非阿片类替代药物。在 CLINICALTRIALS.GOV 注册:(NCT04653506),https://register.Clinicaltrials:gov/prs/beta/studies/S000AFOR00000066/recordSummary。
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引用次数: 0
The "full rectangle" sign: a novel method for ultrasonographic diagnosis of fetal aberrant right subclavian artery. 全长方形 "征象:超声诊断胎儿右锁骨下动脉异常的新方法。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-05 DOI: 10.1007/s00404-024-07785-8
Ettie Piura, Offra Engel, Neta Doctory, Ofer Markovitch

Objective: To evaluate the feasibility and accuracy of a novel ultrasonographic screening method for an aberrant right subclavian artery (ARSA) using the novel "full rectangle" method.

Methods: This prospective study was conducted at a tertiary care center, September 2022 to February 2023. The study included unselected pregnant women at 14-38 weeks of gestation referred for routine or targeted anomaly scans. All participants underwent scanning by two experienced sonographers to ascertain the presence or absence of aberrant right subclavian artery (ARSA) using both conventional and novel "full rectangle sign" methods for validation purposes. This is a novel screening method for ARSA that demonstrates the retro-tracheal course at the level of the supra-aortic vessels, forming what we term the "full rectangle sign".

Results: A cohort of 138 patients was enrolled. The "full rectangle" sign was discerned in 6 fetuses with ARSA (4.3%), while the typical three-sided figure of the right subclavian artery was demonstrated in the remaining 132 fetuses (95.7%). The novel method demonstrated 100% feasibility and complete concordance with the conventional method.

Conclusion: The study results indicate that the full rectangle sign serves as an effective and dependable screening tool for identifying ARSA. It offers the advantage of a clear, unobstructed view at a level unaffected by sternum shadowing and eliminates confusion with the azygous vein.

目的评估使用新型 "全矩形 "法进行右锁骨下动脉异常(ARSA)超声筛查的可行性和准确性:这项前瞻性研究于 2022 年 9 月至 2023 年 2 月在一家三级医疗中心进行。研究对象包括未经选择的妊娠 14-38 周的孕妇,她们被转诊接受常规或有针对性的异常扫描。所有参与者均由两名经验丰富的超声技师进行扫描,以确定是否存在异常右锁骨下动脉(ARSA),扫描采用传统方法和新颖的 "全矩形标志 "方法进行验证。这是一种新型的 ARSA 筛查方法,可显示主动脉上血管水平的气管后走向,形成我们所说的 "全矩形征":结果:138 名患者参加了此次筛查。结果:共纳入 138 例患者,其中 6 例(4.3%)胎儿患有 ARSA,其余 132 例(95.7%)胎儿的右锁骨下动脉呈典型的三面形。新方法的可行性为 100%,与传统方法完全一致:研究结果表明,全矩形征是识别 ARSA 的有效而可靠的筛查工具。它的优点是视野清晰、无障碍,不受胸骨阴影的影响,并消除了与颧静脉的混淆。
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引用次数: 0
Birthing positions and mother`s satisfaction with childbirth: a cross-sectional study on the relevance of self determination. 分娩姿势与母亲对分娩的满意度:关于自我决定相关性的横断面研究。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-04 DOI: 10.1007/s00404-024-07770-1
Nadine Scholten, Brigitte Strizek, Mi-Ran Okumu, Ibrahim Demirer, Jan Kössendrup, Lissa Haid-Schmallenberg, Malte Bäckmann, Arno Stöcker, Natalie Stevens, Anna Volkert

Introduction: Considering the inconclusive evidence regarding the clinical benefits of specific birthing positions, emphasis has been placed on adhering to women's preferences during the second stage of labour. Therefore, the present study aimed to assess the association between birthing position, the freedom to choose a birth position during the second stage of labour, and women's subjective satisfaction with childbirth.

Methods: We performed a cross-sectional survey of women 8 or 12 months after a vaginal birth in a hospital. The women were recruited via two cooperating health insurance companies. Multivariate analyses were conducted to assess the strength of the association between birthing position and maternal satisfaction with childbirth, with a particular focus on interactions with self-determination.

Results: In total, the data from 761 women were analysed. The supine position was the most frequently reported birthing position in the second stage of labour at 77.5%. Notably, 39.0% and 30.5% of the women who gave birth in the dorsal and lateral supine positions, respectively, stated that the birth position was not chosen voluntarily. The regression models show a significant negative association between supine birthing position and satisfaction with childbirth, which is significantly related to self-determination. The most common reason for the adoption of a specific birthing position was instructions from medical staff.

Discussion: The data provide insight into the perceived satisfaction with childbirth depending on the birthing position, whereby the relevance of self-determination is particularly evident. At the same time, self-determination is often not given, which is associated with reduced birth satisfaction.

导言:考虑到有关特定分娩体位临床益处的证据尚无定论,人们强调在第二产程中应遵从产妇的喜好。因此,本研究旨在评估分娩体位、第二产程中选择分娩体位的自由度与产妇对分娩的主观满意度之间的关系:我们对在医院经阴道分娩后 8 个月或 12 个月的产妇进行了横断面调查。这些妇女是通过两家合作的医疗保险公司招募的。我们进行了多变量分析,以评估分娩姿势与产妇分娩满意度之间的关联强度,尤其关注与自我决定之间的相互作用:结果:共分析了 761 名产妇的数据。仰卧位是第二产程中最常见的分娩姿势,占 77.5%。值得注意的是,分别有 39.0%和 30.5%采用背仰卧位和侧仰卧位分娩的产妇表示,分娩姿势并非自愿选择。回归模型显示,仰卧位分娩姿势与分娩满意度之间存在明显的负相关,而分娩满意度与自决有很大关系。采用特定分娩姿势的最常见原因是医务人员的指示:讨论:这些数据让我们深入了解了不同分娩姿势对分娩满意度的影响,其中自我决定的相关性尤为明显。与此同时,自主决定权往往不被给予,这与分娩满意度降低有关。
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引用次数: 0
Does the timing of postprandial glucose monitoring affect the obstetric and neonatal outcomes in patients with gestational diabetes? A prospective study comparing 1 and 2-h postprandial monitoring. 餐后血糖监测的时间会影响妊娠糖尿病患者的产科和新生儿预后吗?一项比较餐后 1 小时和餐后 2 小时监测的前瞻性研究。
IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-04 DOI: 10.1007/s00404-024-07803-9
Noa Ben Shoshan, Yossi Mizrachi, Liliya Tamayev, Tal Ben-Ari, Eran Weiner, Giulia Barda

Objective: The aim of this study was to examine the obstetrical and neonatal outcomes in patients with gestational diabetes mellitus (GDM) who had postprandial glucose monitoring 1 vs. 2 h following meals.

Study design: In this prospective cohort study, we included patients with GDM who were referred to our medical center between July 2019 and June 2021. Patients chose the timing of postprandial glucose monitoring based on their own preferences. Obstetrical and neonatal outcomes, as well as patient satisfaction, were compared between patients who performed postprandial glucose monitoring 1 and 2 h after meals (PPG1 vs. PPG2). The primary outcome was birth weight. The study was powered to detect a 250 g increase in birth weight.

Results: Overall, 99 patients were included: 50 in the PPG1 group and 49 in the PPG2 group. Baseline characteristics were comparable between the groups. Neonates in the PPG1 and PPG2 groups had similar birth weights (3319 ± 355 vs. 3319 ± 520 g, respectively, p = 0.99). Glycemic control, mode of delivery, gestational age at delivery, and satisfaction rates were also similar between the study groups.

Conclusion: In patients with GDM, performing1 vs. 2 h following meals resulted in similar obstetrical and neonatal outcomes and similar satisfaction rates. We therefore recommend counseling patients to choose either strategy based on their personal preference.

研究目的本研究旨在探讨妊娠糖尿病(GDM)患者餐后1小时与餐后2小时接受餐后血糖监测的产科和新生儿结局:在这项前瞻性队列研究中,我们纳入了2019年7月至2021年6月期间转诊至本医疗中心的GDM患者。患者根据自己的喜好选择餐后血糖监测的时间。我们比较了餐后 1 小时和餐后 2 小时进行餐后血糖监测(PPG1 与 PPG2)的患者的产科和新生儿结局以及患者满意度。主要结果是出生体重。研究结果表明,出生体重增加 250 克时,就能检测到该结果:共纳入 99 名患者:PPG1组和PPG2组各有50人和49人。两组的基线特征相当。PPG1 组和 PPG2 组新生儿的出生体重相似(分别为 3319 ± 355 克和 3319 ± 520 克,P = 0.99)。研究组之间的血糖控制、分娩方式、分娩时的胎龄和满意率也相似:结论:对于 GDM 患者,餐后 1 小时与餐后 2 小时的产科和新生儿结局相似,满意率也相似。因此,我们建议指导患者根据个人喜好选择其中一种策略。
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引用次数: 0
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Archives of Gynecology and Obstetrics
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