Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-09-28 DOI:10.1007/s00404-024-07752-3
Koray Gorkem Sacinti, Rowaida Sadat, Sinan Ozkavukcu, Meltem Sonmezer, Murat Sonmezer
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Abstract

Ovarian tissue cryopreservation and transplantation (OTCT) offers hope for preserving fertility and endocrine functions in patients undergoing gonadotoxic treatments. Advancements in techniques for the procedure have transformed OTCT from an experimental procedure into a viable option. There is a growing interest in utilizing OTCT to delay menopause and alleviate associated health issues. Menopausal transition affects women globally, leading to symptoms and long- term health risks. OTCT has the potential to restore endocrine functions, reducing menopause-related symptoms while mitigating health consequences such as osteoporosis and cardiovascular diseases. Although the use of OTCT for delaying menopause is not clinically proven, the discussion around shows potential for future utilization. In essence, the remarkable advancements in OTCT have bestowed upon us the ability to safeguard fertility and sustain the delicate endocrine functions of the ovaries. However, it is the tantalizing prospect of utilizing this technique to postpone menopause and alleviate its associated symptoms that truly captivates the imagination. Further research is imperative to substantiate the clinical efficacy of OTCT; nonetheless, its potential in menopausal therapy is both promising and warrants comprehensive exploration. This review highlights advancements and the feasibility of OTCT to postpone menopause as an alternative approach to currently used conventional menopause therapy methods.

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将卵巢组织冷冻保存和移植作为推迟绝经期的自然手段。
卵巢组织冷冻保存和移植(OTCT)为接受性腺毒性治疗的患者保留生育能力和内分泌功能带来了希望。手术技术的进步使卵巢组织冷冻保存和移植从一种实验性手术变成了一种可行的选择。人们对利用 OTCT 推迟更年期和缓解相关健康问题的兴趣与日俱增。更年期过渡影响着全球妇女,导致各种症状和长期健康风险。OTCT 有可能恢复内分泌功能,减轻更年期相关症状,同时减轻骨质疏松症和心血管疾病等健康后果。尽管将 OTCT 用于推迟绝经期尚未得到临床验证,但围绕 OTCT 的讨论显示了未来使用的潜力。从本质上讲,OTCT 的卓越进步赋予了我们保障生育能力和维持卵巢微妙内分泌功能的能力。然而,利用这种技术推迟更年期并缓解相关症状的诱人前景才真正吸引了人们的想象力。要证实 OTCT 的临床疗效,进一步的研究势在必行;然而,它在更年期治疗方面的潜力是巨大的,值得全面探索。本综述重点介绍了OTCT作为目前使用的传统更年期治疗方法的替代方法,在推迟更年期方面取得的进展和可行性。
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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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