Cortical activation during the verbal fluency task for obstructive sleep apnea patients with depressive symptoms: A multi-channel fNIRS study

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2024-09-29 DOI:10.1002/brb3.70038
Xuan Zhang, Ning Zhang, Yang Yang, Shuo Wang, Ping Yu, Chun-Xue Wang
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引用次数: 0

Abstract

Study objective

The aim of our study was to elucidate differences in brain activity patterns among obstructive sleep apnea (OSA) patients, OSA patients with depressive symptoms, and healthy controls (HCs). We also investigated the relationship between brain function and depression in OSA patients.

Methods

A total of 95 subjects were included in the study, including 34 OSA patients without depressive symptoms, 31 OSA patients with depressive symptoms, and 30 HCs. The 53-channel functional near-infrared spectroscopy (fNIRS) was used to monitor the concentration of oxy-hemoglobin (Oxy-Hb) in the brain, whereas the participants performed the verbal fluency task, and the degree of depression was scored using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Hierarchical regression models were conducted to analyze the association of fNIRS features with depressive symptom.

Results

The Oxy-Hb changes of the three groups were significantly different in Channels 25 (H = 9.878, p = .007) and 43 (H = 6.957, p = .031). Inter-group comparisons showed that the Oxy-Hb change of Channel 25 (located in the dorsolateral prefrontal cortex [DLPFC]) in OSA group was less than that in HC group (p = .006), and the Oxy-Hb change of Channel 43 (located in the right frontal polar region) in OSA group with depression was less than that in OSA group (p = .025). Spearman's test showed that there was a significant negative correlation between HAMD-17 scores and mean Oxy-Hb changes in Channel 43 (r = −.319, p < .05) in the OSA patients. Using hierarchical regression, Oxy-Hb changes in Channel 43 accounted for a significant proportion of the variation in outcome variables, even when accounting for other polysomnography features.

Conclusions:

Changes in the hemodynamic response of DLPFC may be a potential mechanism of executive dysfunction in OSA patients. And the right frontal polar region may be significant in assessing depressive symptoms in patients with OSA.

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有抑郁症状的阻塞性睡眠呼吸暂停患者在语言流畅性任务中的皮层激活:多通道 fNIRS 研究。
研究目的我们的研究旨在阐明阻塞性睡眠呼吸暂停(OSA)患者、伴有抑郁症状的OSA患者和健康对照组(HCs)之间大脑活动模式的差异。我们还研究了 OSA 患者大脑功能与抑郁症之间的关系:研究共纳入 95 名受试者,包括 34 名无抑郁症状的 OSA 患者、31 名有抑郁症状的 OSA 患者和 30 名健康对照组(HCs)。采用 53 通道功能性近红外光谱(fNIRS)监测大脑中氧血红蛋白(Oxy-Hb)的浓度,同时让受试者完成语言流畅性任务,并使用 17 项汉密尔顿抑郁评定量表(HAMD-17)对受试者的抑郁程度进行评分。研究人员采用层次回归模型分析了fNIRS特征与抑郁症状的关联:结果:三组的血氧-血红蛋白变化在通道 25(H = 9.878,p = .007)和通道 43(H = 6.957,p = .031)有显著差异。组间比较显示,OSA组第25通道(位于背外侧前额叶皮层[DLPFC])的Oxy-Hb变化小于HC组(p = .006),OSA伴抑郁组第43通道(位于右额极区)的Oxy-Hb变化小于OSA组(p = .025)。DLPFC血流动力学反应的变化可能是导致OSA患者执行功能障碍的潜在机制。右额极区可能对评估 OSA 患者的抑郁症状有重要意义。
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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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