Brain and Behavior最新文献

The cover image is based on the Original Article Markers of too little effort or too much alertness during neuropsychological assessment: Demonstration with perioperative changes by Dana Baron-Shahaf et al., https://doi.org/10.1002/brb3.3649.

Objective: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) database, the primary objective of this investigation was to examine the relationship between dietary fiber intake (DFI) and sleep disorders.

Methods: For analysis, data from three consecutive cycles of NHANES (2009-2014) were pooled. The independent variable of interest was DFI, while the dependent variable was sleep disorders. Weighted logistic regression was employed to model the relationship between the two variables. Subgroup analyses were conducted, stratified, and adjusted to explore the association between DFI and sleep disorders.

Results: This study encompassed a cohort of 14,360 samples. Logistic regression results revealed a significant inverse association between higher DFI and the risk of sleep disorders (OR: 0.99, 95% CI: 0.98-1.00, p = 0.005). Stratified analysis demonstrated significant interactive effects of gender and physical activity on the association between DFI and sleep disorders (interaction p = 0.017, p = 0.061). Quartile-stratified analysis of DFI showed that in the crude model, Q4 exhibited a significant protective impact against sleep disorders (OR: 0.76, 95% CI: 0.59-0.97, p = 0.026). In model I, which adjusted for demographic characteristics only, Q3 (OR: 0.74, 95% CI: 0.56-0.98, p = 0.036) and Q4 (OR: 0.70, 95% CI: 0.55-0.90, p = 0.006) had significant protective effects on sleep disorders. Additionally, gender subgroup analysis revealed that DFI had a significant impact on the female population, particularly in postmenopausal women, and was more pronounced in subjects with BMI > 30 kg/m² (p = 0.011). Within the physical activity subgroup, there was a certain effect of DFI on improving sleep disorders in individuals with low activity intensity.

Conclusion: Increasing DFI had a protective effect in reducing the risk of sleep disorders. This protective effect may be more pronounced in the female population and individuals with low physical intensity.

Objective: To summarize and evaluate evidence pertaining to the clinical, genetic, histopathological, and neuroimaging correlates of cognitive and behavioral dysfunction in amyotrophic lateral sclerosis (ALS).

Methodology: We comprehensively reviewed the literature on cognitive and behavioral manifestations of ALS, narrating findings from both cross-sectional and longitudinal studies. We discussed knowledge gaps in the evidence base and key limitations affecting studies to date, before formulating a framework for future research paradigms aimed at investigating clinicopathological correlates of neuropsychological dysfunction in ALS.

Results: Studies have demonstrated clinical associations with cognitive dysfunction in ALS e.g., bulbar-onset of symptoms, pathological associations (extramotor TDP-43 deposition), and imaging associations (frontotemporal involvement). The most common behavioral deficit, apathy, is highly associated with verbal fluency, but longitudinal studies assessing behavioral dysfunction in ALS are comparatively lacking.

Conclusion: Longitudinal studies have been helpful in identifying several potential correlates of cognitive and behavioral dysfunction but have frequently been confounded by selection bias and inappropriate testing platforms. This review provides a framework for more robust assessment of clinicopathological associations of neuropsychological abnormalities in ALS in the future, advocating for greater utilization of pre-symptomatic C9orf72 repeat expansion-carrying cohorts.

Background: One of the obstacles to seeking help for suicide is its social stigma. The literature suggests that suicide knowledge could impact this stigma. The present study aims to examine levels and predictors of suicide stigma and suicide literacy among Spanish-speaking individuals from Spain and Latin America.

Method: A total of 678 adults completed an online survey conducted from December 2021 to May 2022. The survey assessed sociodemographic and clinical variables, including the Literacy of Suicide Scale (LOSS-SF) and Stigma of Suicide Scale (SOSS-SF).

Results: Results showed the presence of stigmatization and a moderate level of suicide literacy. Latin Americans presented significantly more stigmatizing attitudes and lower levels of suicide literacy than Spaniards. Older age and stronger religious/spiritual beliefs were correlated with lower suicide literacy. Suicide stigma was regressed on lower suicide literacy, gender (men), stronger religious/spiritual beliefs, and lacking knowledge about how to find help. Furthermore, the region was significantly associated with the suicide glorification subscale, reporting Latin Americans' greater glorification.

Conclusions: By examining these factors, we aim to foster a deeper understanding of the attitudes and beliefs toward suicide. This understanding is crucial, as it may inform the development of effective interventions and prevention strategies that are culturally sensitive and tailored to diverse populations.