Diagnostic Value of Serum Apolipoprotein B100 Combined With Hippocampal Volume in Alzheimer's Disease

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2024-09-30 DOI:10.1002/brb3.70066

Dandan Zhang, Jing Wu, Guoqiang Ren, Yi Wang, Hang Xu, Siyuan Chen, Xuezhong Li, Xiaopeng Chen

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Abstract

Purpose

To explore the diagnostic value of serum apolipoprotein B100 (Apo B100) combined with hippocampal volume in Alzheimer's disease (AD).

Methods

A total of 59 AD patients and 59 healthy subjects were selected. The Mini-Mental State Examination (MMSE) was used for neuropsychological assessment. Blood glucose and serum lipid levels were detected by biochemical analyzer. Polymerase chain reaction (PCR) was used to detect apolipoprotein E (Apo E) ε3/ε4 genotypes in the plasma. Hippocampal volume was calculated using Slicer software. Independent-sample t test or Mann–Whitney U test were used to compare the levels of various indicators between the two groups. Spearman's correlation analysis was used to analyze the correlation between each level. The receiver operating characteristic curve (ROC) was plotted, and the area under the curve (AUC) was calculated to compare the diagnostic efficacy of individual and combined detection of serum Apo B100 levels and hippocampal volume in AD.

Results

Compared with the healthy control group, the levels of serum total cholesterol (TC), low-density lipoprotein (LDL), Apo B100, and plasma Apo E ε3/ε4 were higher in the AD group, and serum high-density lipoprotein (HDL) level was lower in the AD group (both p < 0.05). The hippocampal volume in the AD group was lower than in the control group (p < 0.01). The serum Apo B100 level was negatively correlated with MMSE score (r = −0.646), whereas hippocampal volume was positively correlated with MMSE score (r = 0.630). ROC curve analysis showed that the AUC of the combined serum Apo B100 level and hippocampal volume for AD was higher than that of either alone (AUC = 0.821, p < 0.01).

Conclusion

Serum Apo B100 level is elevated, and the hippocampal volume is reduced in AD patients. The combined detection of the two has a higher diagnostic efficiency for AD than other alone and has the potential to become an important indicator for the diagnosis of AD in the future.

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血清载脂蛋白 B100 结合海马体体积对阿尔茨海默氏症的诊断价值

目的：探讨血清载脂蛋白B100（Apo B100）结合海马体积对阿尔茨海默病（AD）的诊断价值：方法：选取59名阿尔茨海默病患者和59名健康受试者。方法：共选取 59 名 AD 患者和 59 名健康受试者，采用迷你精神状态检查（MMSE）进行神经心理评估。生化分析仪检测血糖和血脂水平。聚合酶链反应（PCR）用于检测血浆中载脂蛋白E（Apo E）ε3/ε4的基因型。海马体积用Slicer软件计算。采用独立样本 t 检验或 Mann-Whitney U 检验比较两组间各项指标的水平。斯皮尔曼相关分析用于分析各指标之间的相关性。绘制接收者操作特征曲线（ROC），计算曲线下面积（AUC），比较单独检测和联合检测血清载脂蛋白B100水平和海马体积对AD的诊断效果：结果：与健康对照组相比，AD组血清总胆固醇（TC）、低密度脂蛋白（LDL）、载脂蛋白B100和血浆载脂蛋白E ε3/ε4水平较高，而AD组血清高密度脂蛋白（HDL）水平较低（均为P 结论：血清载脂蛋白B100水平对AD的诊断具有重要意义：AD患者血清载脂蛋白B100水平升高，海马体积缩小。两者联合检测对AD的诊断效率高于单独检测，有望成为未来诊断AD的重要指标。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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