Tobacco Biomarkers by Latino Heritage and Race, U.S., 2007-2014 National Health and Nutrition Examination Survey.

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-09-30 DOI:10.1158/1055-9965.EPI-24-0744
Chelsea Duong, Erik J Rodriquez, Amanda S Hinerman, Somy Hooshmand, Sophie E Claudel, Neal L Benowitz, Eliseo J Perez-Stable
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Abstract

Background: Tobacco biomarkers reflect smoking intensity and are used to assess cessation status. No study has evaluated variation by Latino heritage.

Methods: Data from the 2007-2014 National Health and Nutrition Examination Survey were used to evaluate geometric mean concentrations of serum cotinine and urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), stratified by smoking status and race and ethnicity, and receiver operating characteristic curves estimated values to distinguish smokers from non-smokers by race and ethnicity and Latino heritage.

Results: The sample (n=18,597) was 50.1% female, 16.6% Latino (58.6% Mexican, 10.4% Central American, 9.1% South American, 7.3% Puerto Rican, 3.5% Dominican, 2.7% Cuban, 8.4% Other Latinos, overall), 12.7% Black, and 70.7% White. Black non-smokers and smokers had the highest cotinine concentrations (0.1 ng/mL and 177.1 ng/mL) and among non-smokers, Black individuals had the highest NNAL concentrations (1.4 pg/mL). Latino smokers had the lowest cotinine (32.7 ng/mL) and NNAL (63.9 pg/mL) concentrations. Among Latino smokers, Puerto Rican individuals had higher concentrations of cotinine (100.0 ng/mL) and NNAL (136.4 pg/mL). Cotinine levels defining smoking (Black: 9.1 ng/mL, Latino: 0.9 ng/mL, White: 3.8 ng/mL) and NNAL (Black: 24.1 pg/mL, Latino: 5.7 pg/mL, White: 15.5 pg/mL) varied. Puerto Rican adults (cotinine: 8.5 ng/mL, NNAL: 17.2 pg/mL) had higher levels than Central American (cotinine: 1.0 ng/mL, NNAL: 5.5 pg/mL) and Mexican (cotinine: 0.9 ng/mL, NNAL: 6.0 pg/mL) adults.

Conclusions: Cotinine and NNAL concentrations that define smoking differed by race and ethnicity and by heritage among Latinos, showing meaningful differences.

Impact: Cessation interventions with biomarker validation need to consider Latino heritage.

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按拉丁裔血统和种族划分的烟草生物标志物,美国,2007-2014 年全国健康与营养调查。
背景:烟草生物标志物可反映吸烟强度,并用于评估戒烟状况。目前还没有研究对拉丁裔血统的差异进行评估:方法:利用2007-2014年美国国家健康与营养调查的数据,评估血清可替宁和尿液中4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇(NNAL)总浓度的几何平均浓度,按吸烟状况、种族和民族进行分层,并通过接收器操作特征曲线估算出按种族、民族和拉丁裔区分吸烟者与非吸烟者的数值:样本(n=18,597)中女性占 50.1%,拉丁裔占 16.6%(墨西哥裔占 58.6%,中美洲裔占 10.4%,南美洲裔占 9.1%,波多黎各裔占 7.3%,多米尼加裔占 3.5%,古巴裔占 2.7%,其他拉丁裔占 8.4%),黑人占 12.7%,白人占 70.7%。黑人非吸烟者和吸烟者的可替宁浓度最高(0.1 纳克/毫升和 177.1 纳克/毫升),在非吸烟者中,黑人的 NNAL 浓度最高(1.4 皮克/毫升)。拉丁裔吸烟者的可替宁(32.7 纳克/毫升)和 NNAL(63.9 皮克/毫升)浓度最低。在拉丁裔吸烟者中,波多黎各人的可替宁(100.0 纳克/毫升)和 NNAL(136.4 皮克/毫升)浓度较高。定义吸烟的可替宁水平(黑人:9.1 纳克/毫升,拉丁裔:0.9 纳克/毫升,白人:3.8 纳克/毫升)和 NNAL 水平(黑人:24.1 皮克/毫升,拉丁裔:5.7 皮克/毫升,白人:15.5 皮克/毫升)各不相同。波多黎各成年人(可替宁:8.5 纳克/毫升,NNAL:17.2 皮克/毫升)的水平高于中美洲成年人(可替宁:1.0 纳克/毫升,NNAL:5.5 皮克/毫升)和墨西哥成年人(可替宁:0.9 纳克/毫升,NNAL:6.0 皮克/毫升):结论:在拉美裔人群中,可替宁和 NNAL 的浓度因种族、民族和血统而异,显示出有意义的差异:影响:通过生物标志物验证的戒烟干预措施需要考虑拉丁裔血统。
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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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