A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer.

IF 0.6 Q4 ONCOLOGY Case Reports in Oncological Medicine Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI:10.1155/2024/7998149
Aryan Dalal, Sean Clark-Garvey, Andrew Gdowski, Sophia Zhang, Sara E Wobker, Steven P Rowe, Ersan Altun, Himisha Beltran, Matthew I Milowsky
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Abstract

Introduction: Neuroendocrine/small-cell prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer, which typically develops after prolonged treatment for metastatic castration-resistant disease, but can, less commonly, occur de novo. Case Presentation: We describe a case of de novo NEPC in a tumor with mixed pathology including acinar adenocarcinoma and neuroendocrine/small-cell carcinoma with rapid progression of metastatic disease. Despite initiation of treatment with androgen deprivation therapy (ADT) and chemotherapy, the patient continued to exhibit progression leading to multiple complications including a large bowel obstruction and ultimately progressive hepatic metastases resulting in liver failure. Conclusion: This case illustrates the clinical presentation and highly aggressive nature of de novo NEPC. Recognizing atypical clinical progression in prostate cancer is critical for the detection of NEPC; however, despite early identification and initiation of treatment, the prognosis remains poor, thus highlighting the need for further study into NEPC biology and novel therapeutic approaches.

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一例进展迅速的新发转移性小细胞神经内分泌前列腺癌。
简介神经内分泌/小细胞前列腺癌(NEPC)是一种罕见的侵袭性前列腺癌亚型,通常在长期治疗转移性阉割耐药疾病后发病,但也可能从头开始发病,但并不常见。病例介绍:我们描述了一例新发 NEPC 病例,该患者的肿瘤具有混合病理学,包括尖腺癌和神经内分泌/小细胞癌,且转移性疾病进展迅速。尽管患者开始接受雄激素剥夺疗法(ADT)和化疗,但病情仍在继续发展,导致多种并发症,包括大肠梗阻,最终进展性肝转移导致肝功能衰竭。结论:该病例说明了新发 NEPC 的临床表现和高度侵袭性。识别前列腺癌的非典型临床进展对于检测 NEPC 至关重要;然而,尽管早期识别并开始治疗,预后仍然很差,因此需要进一步研究 NEPC 的生物学特性和新型治疗方法。
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来源期刊
自引率
0.00%
发文量
11
审稿时长
16 weeks
期刊介绍: Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.
期刊最新文献
A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report. Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review. Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma. Diagnosis and Management of a Patient With Chronic Lymphocytic Leukemia and a Concurrent Plasmacytoma. A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer.
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