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A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report. 治疗局部晚期鼻窦癌的新型分次高剂量姑息放疗方案:病例报告。
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9340657
Saif Aljabab, Amna Mohaimeed, Firas AlMomen, Abdullah AlSwailem, Yasir Alayed

Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely.

鼻窦恶性肿瘤(SNMs)是一种罕见的异质性恶性肿瘤,常表现为局部晚期疾病。如果病变范围广且无法切除,预后较差。在这种情况下,通常需要采用大剂量姑息性放疗方案,但理想的剂量和分次放疗方案尚未确定。我们详细介绍了一名 33 岁男性的病例,他最初表现为右脸颊上逐渐增大的肿块。病变活检显示为鳞状细胞癌(SCC)。影像学检查显示该病已发展到晚期,无法切除,并累及多个头颈部亚部位。在接受外部机构的诱导化疗后,病情进一步恶化。患者要求尽快控制肿瘤和症状,以便回国治疗。我们为他提供了大剂量分次姑息放疗,即每天两次,每次四发,每次四分,每次14.80Gy,然后隔天一次,每次五发,每次30Gy,间隔2周。治疗取得了很好的临床效果,症状在短时间内得到缓解,患者可以安全回家。
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引用次数: 0
Supraglottic Neuroendocrine Carcinoma: A Case Report and Literature Review. 声门上神经内分泌癌:病例报告和文献综述。
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6844193
Renda Alhabib, Chaker Zaidi, Abdulrahman Alfryyan, Hanan Albenayyan, Ibrahim Alotain

Neuroendocrine neoplasms (NENs) are rare in the head and neck region, with the larynx being the most common site. To date, nearly 700 cases of laryngeal neuroendocrine carcinoma (NEC) have been reported in the literature, with an estimated incidence as low as 0.23%. This type of cancer is more prevalent among men aged 50-83 who are heavy smokers. NENs encompass paragangliomas and epithelial neoplasms. The latter categories include neuroendocrine tumors, or typical carcinoids, and NECs, or atypical carcinoids. Due to their nonspecific and often misleading presentation, and given the rarity of this condition, optimal management lacks standardization. Treatment typically involves a combination of surgery, chemotherapy, and radiotherapy. We present a case of supraglottic laryngeal NEC in a 61-year-old female nonsmoker. The patient underwent endoscopic excision followed by adjuvant radiotherapy.

神经内分泌肿瘤(NENs)在头颈部地区非常罕见,喉部是最常见的部位。迄今为止,已有近 700 例喉神经内分泌癌(NEC)的文献报道,估计发病率低至 0.23%。这种癌症多发于 50-83 岁的重度吸烟男性。NEN 包括副神经节瘤和上皮肿瘤。后者包括神经内分泌肿瘤或典型类癌,以及 NECs 或不典型类癌。由于类癌的表现不具特异性且经常会误导患者,再加上这种疾病的罕见性,因此缺乏标准化的最佳治疗方法。治疗方法通常包括手术、化疗和放疗。我们介绍了一例 61 岁女性非吸烟者的声门上型喉 NEC。患者接受了内窥镜切除术,随后接受了辅助放疗。
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引用次数: 0
Case Report: An Extremely Rare Case of Epitheloid Type Leiomyoma. 病例报告:极罕见的上皮样子宫肌瘤病例
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2259872
Mokhamad Zhaffal, Shazia Tariq, Anastasia Salame

Introduction: Uterine leiomyomas are a frequent finding in women of reproductive age. However, rare, unusual growth patterns exist, such as atypical, cellular, mitotically active, myxoid, and epithelioid leiomyomas, and present a major concern as they mimic highly malignant uterine tumors such as uterine leiomyosarcomas. An example of such cases is the epithelial type leiomyoma which is the subject of our report in a 35-year-old female. Case: A 35-year-old, nulliparous lady presented with abnormal uterine bleeding to the emergency department. Workup revealed a suspicious uterine mass that was extending from the intramural part of the fundus down the cervical os. The patient was managed by open myomectomy without complications. The final pathology report revealed an extremely rare benign epithelial type leiomyoma, no malignancy, areas with minimal atypia and low mitotic activity (< 5/10 high power fields), and areas of focal necroses (possibly ischemic type) were seen. No coagulative tumor necrosis was noted. Conclusion: Uterine leiomyomas are a common pathology of the uterus that can be confused with malignant tumors, especially in the setting of unusual growth patterns such as the epitheloid leiomyomas. Definitive management involves myomectomies with regular follow-up with favourable prognosis. It is important to properly manage these cases to avoid the overdiagnosis and mistreatment not to mention the repercussion of false diagnoses on the patient's mental health and well-being.

导言子宫子宫肌瘤是育龄妇女的常见病。然而,也存在一些罕见的异常生长模式,如非典型、细胞性、有丝分裂活跃型、肌样和上皮样子宫肌瘤,它们会模仿高度恶性的子宫肿瘤,如子宫肌瘤。我们报告的一名 35 岁女性患上的上皮型子宫肌瘤就是此类病例的一个例子。病例:一名 35 岁的无子宫女性因异常子宫出血到急诊科就诊。检查发现一个可疑的子宫肿块,肿块从子宫底的内膜部分向下延伸至宫颈口。患者接受了开腹子宫肌瘤剔除术,未出现并发症。最终的病理报告显示,这是一种极其罕见的良性上皮型子宫肌瘤,没有恶变,不典型性极低,有丝分裂活性也很低(结论:子宫肌瘤是一种非常罕见的良性肿瘤:子宫肌瘤是一种常见的子宫病变,容易与恶性肿瘤混淆,尤其是在上皮样子宫肌瘤等生长方式异常的情况下。确定性治疗包括子宫肌瘤切除术和定期随访,预后良好。正确处理这些病例非常重要,以避免过度诊断和错误治疗,更不用说错误诊断对患者心理健康和幸福的影响。
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引用次数: 0
Diagnosis and Management of a Patient With Chronic Lymphocytic Leukemia and a Concurrent Plasmacytoma. 慢性淋巴细胞白血病和浆细胞瘤并发症患者的诊断和治疗。
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8870681
Danielle C Thor, Rohan Umrani, Jack Bergal, Charles Yang, Richard Gordon

Chronic lymphocytic leukemia (CLL) typically presents as an indolent disease with a benign disposition in most patients. In select patients, CLL can progress into a more aggressive disease via its original morphology, following a Richter transformation to an alternative non-Hodgkin's lymphoma, or with the concomitant development of multiple myeloma. In an extremely rare subset of individuals with CLL, an extramedullary plasmacytoma may coexist. This case report seeks to describe the diagnosis and treatment of a patient with concurrent CLL and a plasmacytoma.

慢性淋巴细胞白血病(CLL)在大多数患者中通常表现为一种症状不明显的良性疾病。某些患者的慢性淋巴细胞白血病可能会通过其原始形态发展为更具侵袭性的疾病,或在里氏转化为另一种非霍奇金淋巴瘤后发展为慢性淋巴细胞白血病,或同时发展为多发性骨髓瘤。在 CLL 患者中,极少数人可能同时患有髓外浆细胞瘤。本病例报告旨在描述一名同时患有CLL和浆细胞瘤的患者的诊断和治疗情况。
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引用次数: 0
A Case of Rapidly Progressive De Novo Metastatic Small-Cell Neuroendocrine Prostate Cancer. 一例进展迅速的新发转移性小细胞神经内分泌前列腺癌。
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI: 10.1155/2024/7998149
Aryan Dalal, Sean Clark-Garvey, Andrew Gdowski, Sophia Zhang, Sara E Wobker, Steven P Rowe, Ersan Altun, Himisha Beltran, Matthew I Milowsky

Introduction: Neuroendocrine/small-cell prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer, which typically develops after prolonged treatment for metastatic castration-resistant disease, but can, less commonly, occur de novo. Case Presentation: We describe a case of de novo NEPC in a tumor with mixed pathology including acinar adenocarcinoma and neuroendocrine/small-cell carcinoma with rapid progression of metastatic disease. Despite initiation of treatment with androgen deprivation therapy (ADT) and chemotherapy, the patient continued to exhibit progression leading to multiple complications including a large bowel obstruction and ultimately progressive hepatic metastases resulting in liver failure. Conclusion: This case illustrates the clinical presentation and highly aggressive nature of de novo NEPC. Recognizing atypical clinical progression in prostate cancer is critical for the detection of NEPC; however, despite early identification and initiation of treatment, the prognosis remains poor, thus highlighting the need for further study into NEPC biology and novel therapeutic approaches.

简介神经内分泌/小细胞前列腺癌(NEPC)是一种罕见的侵袭性前列腺癌亚型,通常在长期治疗转移性阉割耐药疾病后发病,但也可能从头开始发病,但并不常见。病例介绍:我们描述了一例新发 NEPC 病例,该患者的肿瘤具有混合病理学,包括尖腺癌和神经内分泌/小细胞癌,且转移性疾病进展迅速。尽管患者开始接受雄激素剥夺疗法(ADT)和化疗,但病情仍在继续发展,导致多种并发症,包括大肠梗阻,最终进展性肝转移导致肝功能衰竭。结论:该病例说明了新发 NEPC 的临床表现和高度侵袭性。识别前列腺癌的非典型临床进展对于检测 NEPC 至关重要;然而,尽管早期识别并开始治疗,预后仍然很差,因此需要进一步研究 NEPC 的生物学特性和新型治疗方法。
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引用次数: 0
Successful Preoperative Radiotherapy for Neglected Shoulder Liposarcoma: A Retrospective Case Report. 被忽视的肩部脂肪肉瘤术前放疗成功:回顾性病例报告
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5782352
Camilla Linhart, Craig MacLeod

This study examines a unique case of a 61-year-old male with a 5-year history of a progressively growing mass above his right shoulder, diagnosed as a dedifferentiated pleomorphic liposarcoma. Using computerized tomography-guided core needle biopsy, the tumour was identified as intermediate to high grade. Surgical removal required preoperative radiotherapy to reduce the size of the tumour. Several unique characteristics set apart this particular case of liposarcoma: its substantial size, its unpredictable growth pattern, its absence of metastasis, and notably, its prolonged period of being untreated. This case report outlines the clinical background, diagnostic procedures, and treatment modalities employed in managing this condition, emphasizing a localized dual therapy approach combining radiotherapy and surgery. Emphasis is placed on distinguishing liposarcoma from lipoblastoma, a benign adipocyte tumour, to facilitate accurate diagnosis and appropriate treatment selection. The positive result achieved in this case could provide valuable insights for the future treatment and management of similarly sized aggressive tumours.

本研究探讨了一例独特的病例:一名 61 岁男性的右肩上方肿块逐渐增大,病史长达 5 年,诊断为脱分化多形性脂肪肉瘤。通过计算机断层扫描引导下的核心针活检,该肿瘤被确定为中高级肿瘤。手术切除需要术前放疗来缩小肿瘤。该脂肪肉瘤病例有几个独特之处:体积巨大、生长模式难以预测、没有转移,尤其是长期未接受治疗。本病例报告概述了该病的临床背景、诊断程序和治疗方法,强调了结合放疗和手术的局部双重治疗方法。报告强调了脂肪肉瘤与脂肪母细胞瘤(一种良性脂肪细胞肿瘤)的鉴别,以便于准确诊断和选择适当的治疗方法。本病例取得的积极疗效可为今后治疗和管理类似大小的侵袭性肿瘤提供有价值的启示。
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引用次数: 0
A Rare Case of Small Intestinal Cancer With Uterine Metastasis After Surgery for Ovarian Metastasis, Diagnosed Using Immunostaining. 利用免疫染色法诊断卵巢转移手术后伴有子宫转移的小肠癌罕见病例
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-08-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8551816
Sachiko Nagao, Motoki Matsuura, Shoko Kurokawa, Masato Tamate, Taishi Akimoto, Tsuyoshi Saito

Uterine metastases from extragenital sites are rare. We present a case of a woman who had undergone surgery for small intestinal cancer and subsequently developed metastases in her left ovary and uterus. A nulliparous woman in her 50s underwent laparoscopic partial small bowel resection with lymph node dissection for small intestinal cancer. Five months later, computed tomography (CT) revealed a left ovarian tumor and ascites. She underwent bilateral adnexectomy and adjuvant chemotherapy, and the ovarian tumor was diagnosed as a small intestinal cancer metastasis. Two years after the small intestinal cancer surgery, a positron emission tomography (PET)-CT scan revealed a uterine accumulation. Cervical cytology was negative for intraepithelial lesion or malignancy. Endometrial histology showed an adenocarcinoma of the uterus. The patient underwent total abdominal hysterectomy followed by adjuvant chemotherapy. Histopathology and immunohistochemistry of the uterine tumor revealed that it was a metastasis of small intestinal cancer (Cytokeratin 7 [CK7] [-], Cytokeratin 20 [CK20] [+], Special AT-Rich Sequence-Binding Protein 2 [SATB2] [+], Paired Box Gene 2 [PAX2] [-], and estrogen receptor [ER] [-]). In patients with cancer, histopathology and immunohistochemistry are important for distinguishing between primary and metastatic tumors and for guiding the choice of treatment.

从生殖器外部位转移到子宫的情况非常罕见。我们介绍了一例女性病例,她曾接受过小肠癌手术,随后出现左侧卵巢和子宫转移。一名 50 多岁的无子宫妇女因患小肠癌接受了腹腔镜小肠部分切除术和淋巴结清扫术。五个月后,计算机断层扫描(CT)发现左侧卵巢肿瘤和腹水。她接受了双侧附件切除术和辅助化疗,卵巢肿瘤被诊断为小肠癌转移。小肠癌手术两年后,正电子发射断层扫描(PET)-CT 扫描发现子宫积液。宫颈细胞学检查未发现上皮内病变或恶性肿瘤。子宫内膜组织学检查显示为子宫腺癌。患者接受了全腹子宫切除术,随后接受了辅助化疗。子宫肿瘤的组织病理学和免疫组化结果显示,这是一种小肠癌转移瘤(细胞角蛋白7 [CK7] [-]、细胞角蛋白20 [CK20] [+]、特殊AT-富序列结合蛋白2 [SATB2] [+]、配对盒基因2 [PAX2] [-]和雌激素受体[ER] [-])。对于癌症患者来说,组织病理学和免疫组化对于区分原发性和转移性肿瘤以及指导治疗方案的选择非常重要。
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引用次数: 0
First Description of the Clinical Activity of Avapritinib in Sporadic Mesenteric Desmoid Tumor. 首次描述阿伐替尼对散发性肠系膜蝶形细胞瘤的临床活性
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-08-05 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8684418
Rebecca Ganzon, Wei Chen, Gabriel Tinoco

Desmoid tumors (DTs) are rare and locally aggressive with a high rate of local recurrence even with optimal surgical resection. Systemic treatments are often utilized for desmoid cases with high risk of surgical morbidity or for local and symptomatic control of recurrent disease. However, the systemic treatment options for DTs are limited with limited responses. Avapritinib is a tyrosine kinase inhibitor (TKI) approved in 2020 for adults with unresectable or metastatic gastrointestinal (GI) stromal tumors (GISTs) harboring a platelet-derived growth factor receptor alpha (PDGFRA) Exon 18 mutation, including D842V mutations. In this case report, we describe a 55-year-old man with a history of D842V-mutant gastric GIST who presented several years after complete resection of the GIST with an enlarging soft tissue mass in the small intestine. After a nondiagnostic biopsy, the patient was started on avapritinib due to concerns for recurrent D842V-mutant GIST. The tumor had a partial response to treatment by RECIST 1.1 criteria, and the patient underwent surgical resection. The final pathology report revealed a sporadic DT. To our knowledge, this is the first known description of the activity of avapritinib in the treatment of a sporadic mesenteric DT, which is relevant given the limited treatment options for patients with this diagnosis. This clinical finding may be worth exploring in a dedicated clinical trial.

蝶形细胞瘤(DTs)是一种罕见的局部侵袭性肿瘤,即使进行了最佳的手术切除,局部复发率也很高。对于手术发病风险较高的类脂样瘤病例,或者为了控制复发疾病的局部症状,通常会采用全身治疗。然而,DTs 的全身治疗方案有限,且疗效不佳。阿伐替尼是一种酪氨酸激酶抑制剂(TKI),于2020年获批用于治疗携带血小板衍生生长因子受体α(PDGFRA)外显子18突变(包括D842V突变)的不可切除或转移性胃肠道间质瘤(GIST)成人患者。在本病例报告中,我们描述了一名 55 岁的男性,他曾患有 D842V 突变的胃 GIST,在胃 GIST 完全切除术后数年出现小肠软组织肿块增大。在进行无诊断性活检后,由于担心 D842V 突变 GIST 复发,患者开始接受阿伐替尼治疗。根据 RECIST 1.1 标准,肿瘤对治疗有部分反应,患者接受了手术切除。最终的病理报告显示患者为散发性 DT。据我们所知,这是首次描述阿伐替尼在治疗散发性肠系膜 DT 中的活性。这一临床发现值得在专门的临床试验中进行探索。
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引用次数: 0
Pseudomyxoma Peritonei in a Case of Carcinoma Cervix: Subtle Finding With Implications on Management and Prognosis. 宫颈癌病例中的假性腹膜肌瘤:微妙发现对治疗和预后的影响
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3066063
Sarita Kumari, Suvidya Singh

Pseudomyxoma peritonei (PMP) is a well-known entity in gastrointestinal and ovarian tumors of mucinous histology. It has important implications on prognosis depending on whether seen in conjunction with a benign or a malignant tumor. In the current report, we describe a case of PMP in a case of advanced endocervical adenocarcinoma of the cervix which was managed surgically.

腹膜假粘液瘤(PMP)是胃肠道和卵巢粘液组织学肿瘤中众所周知的一种。它对预后有重要影响,这取决于它是与良性肿瘤还是恶性肿瘤同时出现。在本报告中,我们描述了一例经手术治疗的晚期宫颈内膜腺癌中的 PMP 病例。
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引用次数: 0
Cases of Patients Treated in Countries With Limited Resources and Discussed by Experts of the International CML Foundation (iCMLf)-Case No. 1: A Boy Presenting With Priapism and Loss of Vision. 国际骨髓增生性白血病基金会 (iCMLf) 专家讨论的资源有限国家患者治疗病例 - 病例 1:一名出现尿崩症和视力丧失的男孩。
IF 0.6 Q4 ONCOLOGY Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5534445
Nirmalya Roy Moulik, Arlene Harriss-Buchan, Guiseppe Saglio, Nicola Evans, Meinolf Suttorp

Pediatric chronic myeloid leukemia (pCML) is a rare malignancy accounting for only 2%-3% of all childhood leukemias. Due to this rarity, familiarity with pCML is limited among most pediatric practitioners, including even pediatric hemato-oncologists. In low- and middle-income countries (LMICs), limited financial resources and limited data specific to pCML represent obstacles that healthcare providers must face in diagnosing and treating this rare condition in children. The International CML Foundation (iCMLf) is improving outcomes for people with CML in these countries where resources, diagnostics, and access to medicines may be limited (https://www.cml-foundation.org/lmic-programs.html). Virtual meetings with the purpose of teaching participating pediatricians from LMICs of defined geographical regions were organised by the iCMLf in 2023. At a virtual meeting of the South Asia region, the case of a 14-year-old Indian boy was presented diagnosed with CML in a chronic phase complicated by priapism and loss of vision in his left eye due to hyperleukocytosis. Key aspects of this case are discussed in-depth from the perspective of (i) a pediatric hemato-oncologist practicing in a high-income country, (ii) a pediatric hemato-oncologist practicing in a LMIC, (iii) an adult CML hematologist, and (iv) from the iCMLf in improving the care of children with CML worldwide. Thus by discussing a multifaceted complicated case of pCML in written form as well as pointing to the pediatric module of the iCMLf Knowledge Centre will hopefully contribute to minimize existing knowledge gaps in a rare pediatric malignancy.

小儿慢性髓性白血病(pCML)是一种罕见的恶性肿瘤,仅占所有儿童白血病的 2%-3%。由于这种罕见性,大多数儿科医生,甚至包括儿科血液肿瘤专家,对 pCML 的了解都很有限。在中低收入国家(LMICs),有限的财政资源和针对 pCML 的有限数据是医疗服务提供者在诊断和治疗这种罕见儿童疾病时必须面对的障碍。国际骨髓增生性白血病基金会 (iCMLf) 正在改善这些国家骨髓增生性白血病患者的治疗效果,因为这些国家在资源、诊断和药物获取方面可能都很有限 (https://www.cml-foundation.org/lmic-programs.html)。2023 年,iCMLf 组织了虚拟会议,目的是向来自特定地理区域的低收入、中等收入和中等收入国家的儿科医生传授知识。在南亚地区的虚拟会议上,一名 14 岁的印度男孩被诊断为慢性骨髓增生性白血病(CML)慢性期并发症,由于白细胞过多,他的左眼出现视力丧失。我们从以下角度深入讨论了该病例的主要方面:(i) 在高收入国家执业的儿科血液肿瘤学家;(ii) 在低收入国家执业的儿科血液肿瘤学家;(iii) 成人 CML 血液学家;(iv) iCMLf 在改善全球儿童 CML 患者护理方面的作用。因此,通过书面形式讨论 pCML 的多方面复杂病例,并指出 iCMLf 知识中心的儿科模块,希望能有助于最大限度地缩小罕见儿科恶性肿瘤方面现有的知识差距。
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引用次数: 0
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Case Reports in Oncological Medicine
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