Effects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review.

IF 10.9 1区 医学 Q1 INFECTIOUS DISEASES Clinical Microbiology and Infection Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI:10.1016/j.cmi.2024.09.014
Paraskevi C Fragkou, Dimitra Dimopoulou, Charalampos D Moschopoulos, Chrysanthi Skevaki
{"title":"Effects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review.","authors":"Paraskevi C Fragkou, Dimitra Dimopoulou, Charalampos D Moschopoulos, Chrysanthi Skevaki","doi":"10.1016/j.cmi.2024.09.014","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.</p><p><strong>Objectives: </strong>The aim of this review is to provide an insightful overview of the most up-to-date evidence regarding the extent to which the use of corticosteroids (CSs) influences the risk of RVIs.</p><p><strong>Sources: </strong>The PubMed database was searched for studies on the association between CSs and RVIs from inception until 15 December 2023.</p><p><strong>Content: </strong>CSs have differing impacts on the risk of RVIs in asthma and chronic obstructive pulmonary disease, influenced by both the specific virus and the type and dose of CSs. Furthermore, current data demonstrate that CSs may increase the risk of RVIs in patients with systemic lupus erythematosus, rheumatoid arthritis, vasculitis, solid tumours, haematological malignancies, and among transplant recipients.</p><p><strong>Implications: </strong>Large-scale studies are imperative to inform a more accurate and personalized risk stratification for RVIs. This, in turn, will point towards new strategies for RVI prevention and associated morbidity and mortality in high-risk populations.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"43-48"},"PeriodicalIF":10.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Microbiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cmi.2024.09.014","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.

Objectives: The aim of this review is to provide an insightful overview of the most up-to-date evidence regarding the extent to which the use of corticosteroids (CSs) influences the risk of RVIs.

Sources: The PubMed database was searched for studies on the association between CSs and RVIs from inception until 15 December 2023.

Content: CSs have differing impacts on the risk of RVIs in asthma and chronic obstructive pulmonary disease, influenced by both the specific virus and the type and dose of CSs. Furthermore, current data demonstrate that CSs may increase the risk of RVIs in patients with systemic lupus erythematosus, rheumatoid arthritis, vasculitis, solid tumours, haematological malignancies, and among transplant recipients.

Implications: Large-scale studies are imperative to inform a more accurate and personalized risk stratification for RVIs. This, in turn, will point towards new strategies for RVI prevention and associated morbidity and mortality in high-risk populations.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
长期使用皮质类固醇对呼吸道病毒易感性的影响:叙述性综述。
背景:合成糖皮质激素具有强大的免疫调节作用,是最常用的药物之一。然而,它们可能会使患者面临感染风险。它们对呼吸道病毒感染(RVI)发病率的影响仍不清楚:本综述旨在提供有关使用皮质类固醇(CSs)在多大程度上影响 RVIs 风险的最新证据的深刻概述:资料来源:在PubMed数据库中搜索了从开始到2023年12月15日有关皮质类固醇与RVI之间关系的研究:CSs 对哮喘和慢性阻塞性肺病的 RVIs 风险具有不同的影响,这受到特定病毒以及 CSs 类型和剂量的影响。此外,目前的数据表明,CSs 可能会增加系统性红斑狼疮、类风湿性关节炎、血管炎、实体瘤、血液恶性肿瘤患者以及移植受者发生 RVIs 的风险:大规模研究势在必行,以便为更准确、更个性化的 RVI 风险分层提供信息。这反过来又将为高危人群的 RVI 预防及相关发病率和死亡率的新策略指明方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
25.30
自引率
2.10%
发文量
441
审稿时长
2-4 weeks
期刊介绍: Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.
期刊最新文献
Infectious complications in the paediatric immunocompromised host: a narrative review. Advances and prospect in herpesviruses infections after haematopoietic cell transplantation: closer to the finish line? Which trial do we need? A pragmatic randomized trial of trimethoprim-sulfamethoxazole vs. vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia in low-resource settings. How to: assess patient suitability for unlicensed phage therapy in the United Kingdom. Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community-acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1