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Which trial do we need? Defining the optimal duration of antifungal therapy for invasive pulmonary aspergillosis: duration of therapy in invasive aspergillosis. 我们需要哪个试验?确定侵袭性肺曲霉病抗真菌治疗的最佳时间:侵袭性肺曲霉病的治疗时间。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-07 DOI: 10.1016/j.cmi.2026.01.030
Guillaume Desoubeaux, Malgorzata Mikulska, Adrien Lemaignen, Emmanuel Gyan, Jannik Stemler, Yuri Vanbiervliet, Johan Maertens, Olivier Lortholary, Olivier Paccoud, Monica A Slavin, Oliver A Cornely, Dionysios Neofytos, Fanny Lanternier
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引用次数: 0
'Estimating antibiotic resistance following antibiotic treatment in outpatients' - Author's reply. “估计门诊患者抗生素治疗后的抗生素耐药性”——作者回复。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-07 DOI: 10.1016/j.cmi.2026.02.001
Michal Chowers, Dor Atias, Uri Obolski
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引用次数: 0
Genomic determinants of Bacillus cereus and outcomes of infection in preterm neonates: a multicentre retrospective study. 蜡样芽孢杆菌的基因组决定因素和早产儿感染的结果:一项多中心回顾性研究。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-03 DOI: 10.1016/j.cmi.2026.01.023
Alicia Chevalier, Mariem Ben Khedher, Antoine Tran, Matilde Coin, Mélanie Pousse, Asmaa Tazi, Sergio Eleni Dit Trolli, Philippe Lanotte, Christelle Follet, Maxime Pichon, Damien Dubois, Lea Herbulot, Anais Potron, Said Aberrane, André Birgy, Béatrice Boutillier, Alix Pantel, Massimo Di Maio, Gregory Dubourg, Pierre Boyer, Stéphane Corvec, Guillaume Groshenry, Mathilde Bonis, Margot Saissi, Armel Gallet, Laurent Boyer, Olivier Croce, Romain Lotte, Raymond Ruimy

Objectives: Bacillus cereus sensu lato (s.l.) or B. cereus group increasingly causes severe infections in preterm neonates. However, species-level identification and virulence characterization remain limited. This study aimed to identify B. cereus group species responsible for invasive infections in preterm neonates and to correlate genomic virulence profiles with clinical outcomes.

Methods: We conducted a retrospective, multicentre study across 13 French hospitals (2010-21), including 40 B. cereus group isolates from blood or cerebrospinal fluid of preterm neonates with invasive infections. Clinical data were extracted from patient records. Whole-genome sequencing (Illumina and Oxford Nanopore) with hybrid assemblies enabled species identification using digital DNA-DNA hybridisation and average nucleotide identity. Virulence genes were screened against a curated database of 65 virulence genes, and associations with clinical outcomes were analysed.

Results: Forty isolates were analyzed, 42.5% (17/40) of patients developed septic shock, and 37.5% (15/40), died, usually following rapid clinical deterioration. WGS identified seven species, predominantly Bacillus paranthracis (47.5%, 19/40) and B. cereus sensu stricto (20%, 8/40). Virulence gene content varied by species. The presence of hblCDAB (60%, 9/15), nprB (46.5%, 7/15), asbABCDEF (80%, 12/15), and essC-cereus/esxA (66.7%, 10/15) genes correlated with mortality (p=0.00015, 0.002, 0.0027, and 0.02, respectively). B. cereus sensu stricto carried more virulence determinants and was associated with higher mortality than B. paranthracis and other species, at day 7 (p=0.05) and at day 28 (p=0.0065). The cesH gene (60%, 15/25) is significantly associated with survival (p=0.007), particularly with B. paranthacis, the predominant species in our cohort.

Conclusions: Invasive B. cereus group infections in preterm neonates are associated with high mortality, particularly in cases due to B. cereus sensu stricto. WGS enables precise species identification and virulence profiling, which are essential insights for diagnostic refinement, outbreak control, and risk stratification in neonatal intensive care settings.

目的:蜡样芽孢杆菌(Bacillus cereus sensu lato, s.l)或蜡样芽孢杆菌群在早产儿中引起严重感染的比例日益增加。然而,物种水平的鉴定和毒力表征仍然有限。本研究旨在确定蜡样芽孢杆菌群物种负责侵袭性感染的早产儿,并将基因组毒力谱与临床结果相关联。方法:我们在法国13家医院(2010-21年)进行了一项回顾性的多中心研究,包括40例从侵入性感染的早产儿血液或脑脊液中分离出的蜡样芽孢杆菌群。临床资料从患者记录中提取。全基因组测序(Illumina和Oxford Nanopore)与混合组件能够使用数字DNA-DNA杂交和平均核苷酸识别进行物种鉴定。针对65个毒力基因的数据库筛选毒力基因,并分析其与临床结果的关联。结果:40例分离病例中,42.5%(17/40)的患者发生脓毒性休克,37.5%(15/40)的患者死亡,通常因临床迅速恶化而死亡。WGS共鉴定出7种,以副芽孢杆菌(47.5%,19/40)和严格蜡样芽孢杆菌(20%,8/40)为主。毒力基因含量因种而异。hblCDAB(60%, 9/15)、nprB(46.5%, 7/15)、asbABCDEF(80%, 12/15)和essC-cereus/esxA(66.7%, 10/15)基因的存在与死亡率相关(p分别为0.00015、0.002、0.0027和0.02)。在第7天(p=0.05)和第28天(p=0.0065),严格感蜡样芽孢杆菌携带更多的毒力决定因素,死亡率高于副吸芽孢杆菌和其他种类。cesH基因(60%,15/25)与生存率显著相关(p=0.007),特别是与我们队列中的优势种副芽孢杆菌相关。结论:新生儿侵袭性蜡样芽孢杆菌群感染与高死亡率相关,特别是因蜡样芽孢杆菌引起的严感感染。WGS能够实现精确的物种识别和毒力分析,这对改进诊断、疫情控制和新生儿重症监护环境中的风险分层至关重要。
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引用次数: 0
Neisseria meningitidis MenY ST-1466 Harbouring N. gonorrhoeae 16S rRNA Allele Causing False-Positive Aptima® Gonococcal NAAT Results. 携带淋病奈瑟菌16S rRNA等位基因的脑膜炎奈瑟菌MenY ST-1466导致Aptima®淋球菌NAAT结果假阳性
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-02 DOI: 10.1016/j.cmi.2026.01.027
S J van Hal, E Goeman, Y Davidson, F Frances, D M Whiley, M M Lahra
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引用次数: 0
Visceral leishmaniasis in a woman treated by risankizumab for guttate psoriasis. 内脏利什曼病在一名妇女接受利桑单抗治疗guttate牛皮癣。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-02 DOI: 10.1016/j.cmi.2026.01.025
Etienne Rivière, Claire Tinevez, Félix Blaison, Jean-François Viallard, Estibaliz Lazaro, Fabrice Camou
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引用次数: 0
First case of Crimean-Congo hemorrhagic fever in Andalusia, Spain. 西班牙安达卢西亚出现首例克里米亚-刚果出血热病例。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-02 DOI: 10.1016/j.cmi.2026.01.028
María Paniagua-García, Ana Caro-Leiro, María José Gómez-Gómez, Ana Isabel Negredo Antón, Patricia Sánchez-Mora, Julia María Praena-Segovia
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引用次数: 0
Nationwide emergence of cefotaxime-resistant Neisseria meningitidis via interspecies gene transfer from penA795-bearing Neisseria commensals in China. 通过携带pena795的共生奈瑟菌的种间基因转移,在中国全国范围内出现耐头孢噻肟脑膜炎奈瑟菌
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-02 DOI: 10.1016/j.cmi.2026.01.026
Youxing Shao, Xin Lan, Mingliang Chen, Minggui Wang, Qinglan Guo
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引用次数: 0
The path ahead: Building community between palliative care and infectious disease teams. 未来的道路:在姑息治疗和传染病团队之间建立社区。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-02-02 DOI: 10.1016/j.cmi.2026.01.029
Daniel Karlin, Tara Vijayan
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引用次数: 0
Time to blood culture positivity predicts metastatic infection in patients with bloodstream infection and correlates with persistence of detectable pathogens in the bloodstream by culture independent systems. 血培养阳性时间预测血液感染患者的转移性感染,并与培养独立系统在血液中检测到的病原体的持久性相关。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-01-31 DOI: 10.1016/j.cmi.2026.01.024
Anna Maria Peri, Kevin O'Callaghan, Nastaran Rafiei, Mark D Chatfield, Abi Manesh, David L Paterson
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引用次数: 0
Microbiome research in practice: priorities for clinical translation and impact. 微生物组研究在实践中:临床翻译和影响的优先事项。
IF 8.5 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2026-01-31 DOI: 10.1016/j.cmi.2026.01.021
Anastasia Theodosiou, Debby Bogaert, David Cleary, Paul-Enguerrand Fady, Conor Feehily, Jack Gilbert, Beth Greenhough, Luca Guardabassi, Lindsay Hall, Toni Harman, Ed Kuijper, Sarah Lebeer, Jamie Lorimer, Tim Spector, Chrissie Jones

Background: Rapid advances in microbiome science have sparked clinical and commercial enthusiasm for interventions, yet translation into practice risks outpacing both mechanistic understanding and the infrastructure required for safe adoption.

Objectives: To outline a coordinated research, clinical, social, and policy agenda for advancing safe, effective, and equitable microbiome-based interventions.

Sources: We convened an interdisciplinary Royal Society-funded expert workshop (Leeds, UK, October 2024) with international leaders in microbiome science, clinical trials, regulation, and social science. Thematic analysis of workshop discussions and written contributions identified priority domains for translation.

Content: Three intersecting priorities emerged: scientific credibility, practical viability, and stakeholder engagement. Scientific credibility demands investment in multiomic and strain-level characterisation of host-microbiome interactions on a large scale, benchmarking of clinical and microbiological endpoints, and harmonisation of trial conduct and reporting. Clinical adoption requires fit-for-purpose regulation, diversified investment to address funding bottlenecks, and coordinated capacity building. Meaningful stakeholder engagement with clinicians, patients, policymakers, and the public is essential to foster confidence, develop clinically relevant research questions, and ensure equitable implementation of any new technology.

Implications: To realise the clinical impact of microbiome interventions, sustained collaboration across disciplines is essential. This Review offers a translational roadmap and actionable priorities to accelerate safe, effective, and equitable microbiome-based interventions - ensuring the field fulfils its clinical potential and delivers real-world impact.

背景:微生物组科学的快速发展激发了临床和商业对干预措施的热情,但转化为实践的风险超过了机制理解和安全采用所需的基础设施。目标:概述一个协调的研究、临床、社会和政策议程,以推进安全、有效和公平的基于微生物组的干预措施。资料来源:我们召集了一个跨学科的皇家学会资助的专家研讨会(利兹,英国,2024年10月)与微生物组科学,临床试验,法规和社会科学的国际领导者。对研讨会讨论和书面贡献的专题分析确定了翻译的优先领域。内容:出现了三个相互交叉的优先事项:科学可信度、实际可行性和利益相关者参与。科学可信度要求对宿主-微生物组相互作用的多组学和菌株水平特征进行大规模的投资,对临床和微生物终点进行基准测试,以及协调试验行为和报告。临床采用需要有针对性的监管、多样化的投资以解决资金瓶颈,以及协调一致的能力建设。利益相关者与临床医生、患者、政策制定者和公众进行有意义的接触,对于培养信心、提出临床相关研究问题和确保公平实施任何新技术至关重要。启示:为了实现微生物组干预的临床影响,跨学科的持续合作是必不可少的。本综述提供了一个转化路线图和可操作的优先事项,以加速安全、有效和公平的基于微生物组的干预措施-确保该领域发挥其临床潜力并产生实际影响。
{"title":"Microbiome research in practice: priorities for clinical translation and impact.","authors":"Anastasia Theodosiou, Debby Bogaert, David Cleary, Paul-Enguerrand Fady, Conor Feehily, Jack Gilbert, Beth Greenhough, Luca Guardabassi, Lindsay Hall, Toni Harman, Ed Kuijper, Sarah Lebeer, Jamie Lorimer, Tim Spector, Chrissie Jones","doi":"10.1016/j.cmi.2026.01.021","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.01.021","url":null,"abstract":"<p><strong>Background: </strong>Rapid advances in microbiome science have sparked clinical and commercial enthusiasm for interventions, yet translation into practice risks outpacing both mechanistic understanding and the infrastructure required for safe adoption.</p><p><strong>Objectives: </strong>To outline a coordinated research, clinical, social, and policy agenda for advancing safe, effective, and equitable microbiome-based interventions.</p><p><strong>Sources: </strong>We convened an interdisciplinary Royal Society-funded expert workshop (Leeds, UK, October 2024) with international leaders in microbiome science, clinical trials, regulation, and social science. Thematic analysis of workshop discussions and written contributions identified priority domains for translation.</p><p><strong>Content: </strong>Three intersecting priorities emerged: scientific credibility, practical viability, and stakeholder engagement. Scientific credibility demands investment in multiomic and strain-level characterisation of host-microbiome interactions on a large scale, benchmarking of clinical and microbiological endpoints, and harmonisation of trial conduct and reporting. Clinical adoption requires fit-for-purpose regulation, diversified investment to address funding bottlenecks, and coordinated capacity building. Meaningful stakeholder engagement with clinicians, patients, policymakers, and the public is essential to foster confidence, develop clinically relevant research questions, and ensure equitable implementation of any new technology.</p><p><strong>Implications: </strong>To realise the clinical impact of microbiome interventions, sustained collaboration across disciplines is essential. This Review offers a translational roadmap and actionable priorities to accelerate safe, effective, and equitable microbiome-based interventions - ensuring the field fulfils its clinical potential and delivers real-world impact.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Clinical Microbiology and Infection
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