Head to head comparison of ¹⁸F-FDG and Al¹⁸F-NOTA-FAPI-04 PET/CT imaging used in diagnosis of autoimmune rheumatic diseases.

IF 2.9 3区医学 Q2 RHEUMATOLOGY Clinical Rheumatology Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1007/s10067-024-07155-4

Yuan Li, Yunshan Zhou, Jing He, Jinchuan Chen, Hua Zhu, Zhi Yang, Qian Wang, Nan Li

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引用次数: 0

Abstract

Objectives: The aim of this study was to determine the performance of radionuclide-labeled fibroblast activation protein inhibitors (Al¹⁸F-NOTA-FAPI-04) PET/CT in patients with autoimmune rheumatic diseases (ARDs) and compare it with fluorine-18 (¹⁸F) labeled fluorodeoxyglucose (FDG) imaging.

Methods: Fifty-eight participants with ARDs were prospectively enrolled from April 2022 to February 2024 and underwent dual-tracer PET/CT imaging. For both ¹⁸F-FDG and Al¹⁸F-NOTA-FAPI-04 PET/CT, imaging findings were interpreted and compared. The clinical significance was compared between¹⁸F-FDG PET/CT and Al¹⁸F-NOTA-FAPI-04 PET/CT imaging.

Results: ¹⁸F-FDG imaging was positive in 53 out of 58 cases (91.4%) while Al¹⁸F-NOTA-FAPI-04 imaging was positive in 55 out of 58 cases (94.8%). Overall positive rate of Al¹⁸F-NOTA-FAPI-04 imaging was as high as ¹⁸F-FDG imaging (P = 0.625). ¹⁸F-FDG imaging detected more lesions in lymph node, spleen, and bone marrow. Al¹⁸F-NOTA-FAPI-04 imaging detected more lesions in the lung, muscle, and tendon/ligament. There was no statistical difference of composing ratio of grades of clinical significance between two imaging modalities (χ² = 2.875, P = 0.238). The superior rate of Al¹⁸F-NOTA-FAPI-04 PET/CT imaging was higher than ¹⁸F-FDG imaging (P = 0.020). In subgroup of adult-onset Still's disease, ¹⁸F-FDG imaging showed better performance than Al¹⁸F-NOTA-FAPI-04 imaging. In most of the other subgroup of ARDs, Al¹⁸F-NOTA-FAPI-04 PET/CT imaging overperformed ¹⁸F-FDG imaging.

Conclusion: Both ¹⁸F-FDG and Al¹⁸F-NOTA-FAPI-04 PET/CT imaging have excellent sensitivity in ARDs. The detection capabilities of two tracers varied according to the involving organs of ARDs. In most of ARDs except adult-onset Still's disease, Al¹⁸F-NOTA-FAPI-04 PET/CT imaging overperformed ¹⁸F-FDG imaging. Key Points • ¹⁸F-FDG and Al18F-NOTA-FAPI-04 PET/CT imaging have excellent sensitivity in diagnosing of ARDs. • ¹⁸F-FDG PET/CT imaging detected more lesions in lymph node, spleen, and bone marrow. • ¹⁸F-NOTA-FAPI-04 PET/CT imaging detected more lesions in the lung, muscle, and tendon/ligament. • ¹⁸F-NOTA-FAPI-04 PET/CT imaging overperformed¹⁸F-FDG in most subgroups of ARDs.

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用于诊断自身免疫性风湿病的 18F-FDG 和 Al18F-NOTA-FAPI-04 PET/CT 成像的头对头比较。

研究目的本研究旨在确定放射性核素标记的成纤维细胞活化蛋白抑制剂（Al18F-NOTA-FAPI-04）PET/CT在自身免疫性风湿病（ARDs）患者中的表现，并将其与氟-18（18F）标记的氟脱氧葡萄糖（FDG）成像进行比较：从2022年4月到2024年2月，58名患有自身免疫性风湿病的患者接受了双示踪剂PET/CT成像检查。对 18F-FDG 和 Al18F-NOTA-FAPI-04 PET/CT 的成像结果进行解释和比较。比较了 18F-FDG PET/CT 和 Al18F-NOTA-FAPI-04 PET/CT 成像的临床意义：结果：58 例中有 53 例（91.4%）18F-FDG 成像呈阳性，而 58 例中有 55 例（94.8%）Al18F-NOTA-FAPI-04 成像呈阳性。Al18F-NOTA-FAPI-04 成像的总体阳性率与 18F-FDG 成像一样高（P = 0.625）。18F-FDG 成像在淋巴结、脾脏和骨髓中发现的病灶更多。Al18F-NOTA-FAPI-04 成像在肺、肌肉和肌腱/韧带中发现的病变较多。两种成像方式的临床意义分级构成比无统计学差异（χ2 = 2.875，P = 0.238）。Al18F-NOTA-FAPI-04 PET/CT 成像的优于率高于 18F-FDG 成像（P = 0.020）。在成人型斯蒂尔病亚组中，18F-FDG 成像比 Al18F-NOTA-FAPI-04 成像表现更好。结论：18F-FDG和Al18F-NOTA-FAPI-04 PET/CT成像在大多数其他ARD亚组中的表现优于18F-FDG成像：结论：18F-FDG 和 Al18F-NOTA-FAPI-04 PET/CT 成像在 ARD 中都具有出色的灵敏度。两种示踪剂的检测能力因 ARD 涉及的器官而异。在除成人型斯蒂尔病以外的大多数 ARD 中，Al18F-NOTA-FAPI-04 PET/CT 成像优于 18F-FDG 成像。要点 - 18F-FDG 和 Al18F-NOTA-FAPI-04 PET/CT 成像在诊断 ARD 方面具有极高的灵敏度。- 18F-FDG PET/CT 成像能在淋巴结、脾脏和骨髓中发现更多病灶。- 18F-NOTA-FAPI-04 PET/CT 成像可在肺部、肌肉和肌腱/韧带发现更多病变。- 在大多数 ARD 亚组中，18F-NOTA-FAPI-04 PET/CT 成像优于 18F-FDG 成像。

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来源期刊

Clinical Rheumatology 医学-风湿病学

CiteScore

6.90

自引率

2.90%

发文量

441

审稿时长

3 months

期刊介绍： Clinical Rheumatology is an international English-language journal devoted to publishing original clinical investigation and research in the general field of rheumatology with accent on clinical aspects at postgraduate level. The journal succeeds Acta Rheumatologica Belgica, originally founded in 1945 as the official journal of the Belgian Rheumatology Society. Clinical Rheumatology aims to cover all modern trends in clinical and experimental research as well as the management and evaluation of diagnostic and treatment procedures connected with the inflammatory, immunologic, metabolic, genetic and degenerative soft and hard connective tissue diseases.