Ultrasound Evaluations of Ankle and Foot Muscles in Diabetic Peripheral Neuropathy Systematic Review with Meta-Analysis.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-09-26 DOI:10.2174/0115733998310010240711051523
Sharath S, Rajagopal Kadavigere, G Arun Maiya
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Abstract

Background: Diabetic peripheral neuropathy (DPN) is the prevalent microvascular complication of diabetes mellitus (DM). 30-50% of diabetics are likely to be affected by DPN. It significantly impacts the skeletal muscles, resulting in an accelerated loss of muscle mass. The objective of this systematic review was to evaluate the ankle and foot muscle changes in diabetic peripheral neuropathy using ultrasound.

Method: A comprehensive search was conducted in Scopus, Embase, and PubMed databases, which yielded 64 studies, out of which 5 studies are included in this meta-analysis.

Result: The meta-analysis shows that the thickness and cross-section area of the extensor digitorum brevis muscle are reduced in DPN as compared to the control group with p-value<0.004 and p-value<0.001, respectively. The thickness of MIL muscle was also smaller in DPN p-value=0.02. Similarly, the thickness and CSA of AH muscle are also reduced in DPN patients compared to the control group, with p-values of 0.21 and 0.14.

Conclusion: Meta-analysis reveals that diabetic peripheral neuropathy (DPN) patients have reduced foot muscle thickness and cross-sectional area (CSA) compared to controls without neuropathy. This highlights the importance of ultrasound in detecting muscle atrophy early in diabetic patients since it provides objective measures beyond traditional screening with its real-time and non-invasive nature.

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糖尿病周围神经病变中踝关节和足部肌肉的超声评估系统性回顾与 Meta 分析。
背景:糖尿病周围神经病变(DPN)是糖尿病(DM)最常见的微血管并发症。30%-50%的糖尿病患者可能会受到 DPN 的影响。它严重影响骨骼肌,导致肌肉质量加速流失。本系统综述旨在利用超声波评估糖尿病周围神经病变患者踝关节和足部肌肉的变化:方法:在 Scopus、Embase 和 PubMed 数据库中进行了全面检索,共获得 64 项研究,其中 5 项研究被纳入本荟萃分析:结果:荟萃分析表明,与对照组相比,DPN 患者拇趾外展肌的厚度和横截面积均有所减少,P 值为结论:元分析表明,与无神经病变的对照组相比,糖尿病周围神经病变(DPN)患者的足部肌肉厚度和横截面积(CSA)均有所减少。这凸显了超声波在早期检测糖尿病患者肌肉萎缩方面的重要性,因为超声波具有实时性和非侵入性的特点,能提供超越传统筛查的客观测量指标。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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